| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Microinjection of anti cdc25A antibodies into HeLa cells causes their arrest in mitosis . cdc25A and cdc25B display endogenous tyrosine phosphatase activity that is stimulated several fold , in the absence of cdc 2 , by stoichiometric addition of either cyclin B 1 or B 2 but not A or D 1 . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Northern and Western blotting detection reveals that unlike cdc25B , cdc25C and cdc 2 , cdc25A is predominantly expressed in late G 1 . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| When tsBN 2 cells arrested in S phase were incubated at 40 degrees C in the presence of cycloheximide , Cdc25B , but not Cdc25A and C , among a family of dual specificity phosphatases , Cdc 25 , was lost coincidentally with the lack of the activation of p 34 ( cdc 2 ) / cyclin B . ^^^ |
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| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Nuclei derived from normal mucosal epithelium and tumors were analyzed for phosphotyrosyl protein phosphatase activity using the malachite green assay and a synthetic phosphotyrosyl peptide based on the sequence of cdc 2 , a known cdc25A phosphotyrosyl protein substrate . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the protein kinase complexes consisting of cyclin A 1 and either Cdc 2 or Cdk 2 phosphorylate both Cdc25A and Cdc25C in vitro . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| To explain this atypical mitotic activation in neurons we investigated the Cdc 2 activating Cdc25A phosphatase in human brain . ^^^ After immunoprecipitation from control and AD tissue , we found that the tyrosine dephosphorylating activity of Cdc25A against exogenous Cdc 2 substrate was elevated in AD . ^^^ |
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| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| In p 53 ( + / + ) cells , vanadate increased the expression of p 21 and degraded cdc25A instead of cdc25C without any effect on cdc 2 . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| In addition , GEX1A / herboxidiene treatment gave rise to the shorter sized transcripts of the cdc25A and cdc 2 genes as well as the normal sized ones . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Kinase assays revealed that the reduction of p 34 ( CDC 2 ) activity by resveratrol was mediated through the inhibition of CDK 7 kinase activity , while CDC25A phosphatase activity was not affected . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Transfection with dominant negative Cdk mutants demonstrated that only a Cdk 2 mutant increased Cdc25A protein levels ; Cdk 1 and Cdk 3 mutants had no effect . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| DNA damage during the spindle assembly checkpoint degrades CDC25A , inhibits cyclin CDC 2 complexes , and reverses cells to interphase . ^^^ Ectopic expression of CDC25A or nonphosphorylatable CDC 2 effectively inhibited the dephosphorylation of histone H 3 after DNA damage . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| These nine proteins ( DP 1 , cdc25A , cyclin A , cyclin B ( 1 ) , cyclin D ( 1 ) , cdk 1 , cdk 5 , p 21 ( WAF 1 ) , and GADD 153 ) have been reported previously by our laboratory to be modulated by MSA in human breast and prostate cancer cells . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cdc25A is required for S phase entry and dephosphorylates tyrosine 15 phosphorylated Cdk 1 ( Cdc 2 ) and Cdk 2 , positive regulators of cell division . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| This results from the phosphorylation and subsequent inactivation of two inhibitory kinases ( WEE 1 and MYT 1 ) that tonically suppress CDK 2 and CDC 2 activity and activation of a phosphatase ( CDC25A ) that increases CDK 2 activity . . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Disruption of CHK 1 function bypassed the checkpoint , as manifested by the increase in CDC25A , activation of CDC 2 , increase in histone H 3 phosphorylation , and reduction in cell survival after Adriamycin treatment . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results suggest that markedly down regulation of G 1 associated cyclin D 2 , cyclin E and cdc25A and up regulation of CDKI , p 15 and p 27 , and may contribute to I 6 mediated cell cycle arrest . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| We tested 9 extracts isolated from the Chinese medicinal herbs and vegetables including the agents currently used in cancer treatment by measuring the inhibition of Cdc25A phosphatase and Cdc 2 kinase activity . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : The mRNA transcript levels of CDC 2 , CCNB 1 , CCNB 2 , CDC25A , CDC25B , CDC25C and WEE 1 in the testes of 37 azoospermic patients were examined by quantitative real time polymerase chain reaction . ^^^ Significant decreases in CDC 2 , CCNB 1 , CCNB 2 , CDC25A , CDC25C and WEE 1 mRNA transcript levels were detected in patients with spermatogenic failure . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Rep 78 inhibits Cdc25A activity by a novel means in which binding between the two proteins stabilizes Cdc25A , thus increasing its abundance , while at the same time preventing access to its substrates cyclin dependent kinase ( Cdk ) 2 and Cdk 1 . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| Further , three dimensional time lapse microscopy and quantification of Cdk 1 phosphorylation versus cyclin B 1 levels in individual cells revealed that Cdc25A and B exert specific functions in the initiation of mitosis : Cdc25A may play a role in chromatin condensation , whereas Cdc25B specifically activates cyclin B 1 Cdk1 on centrosomes . . ^^^ |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30304 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|