| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p70s6K , Akt , and cdc 2 was evaluated by Western blot . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| Additionally we identified proteins that are novel candidates for mediating the cellular responses to CD 437 ( e . g . , FAF 1 , Bid , caspase 8 , cdk 1 , KAP , NDR , RBBP , 53BP2 , Grb 2 , PLCgamma 1 , p70s6k , PP2Cdelta , PKBalpha / AKT , PDK 1 , and several DNA repair enzymes ) . . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| Expression and immunohistochemical localization of Cdc 2 and P70S6K in different stages of mouse germ cells . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| A previous study has shown that Cdc 2 ( Cdk 1 ) indeed phosphorylates these p 70 ( s6k ) Ser / Thr residues in vitro . ^^^ These data indicate that p 70 ( s6k ) is a physiological substrate of Cdc 2 cyclin B in mitosis . ^^^ Since the activity of p 70 ( s6k ) is low during mitosis , Cdc 2 cyclin B may play a role in inactivating p 70 ( s6k ) during mitosis , where protein synthesis is suppressed . . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| Cells exposed to CDK inhibitors + LY also exhibited reduced phosphorylation of glycogen synthase kinase ( GSK ) 3 , forkhead transcription factor ( FKHR ) , p 70 ( S6K ) , and ERK , but increased activation of p 34 ( cdc 2 ) and p 38 MAPK . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| We report here that ribosomal S 6 kinase 1 ( S6K1 ) , a protein kinase linked to the translation of ribosomal protein mRNAs , is also subject to regulation by Cdc 2 in mitosis . ^^^ In mitotic HeLa cells , when the activity of Cdc 2 is high , S6K1 is phosphorylated at multiple Ser / Thr , Pro ( S / TP ) sites , including Ser ( 371 ) , Ser ( 411 ) , Thr ( 421 ) , and Ser ( 424 ) . ^^^ In murine FT 210 cells arrested in mitosis , conditional inactivation of Cdc 2 reduces phosphorylation of S6K1 at S / TP sites while simultaneously increasing phosphorylation of Thr ( 389 ) and of the S6K1 substrate , RPS 6 . ^^^ A physical interaction exists between Cdc 2 and S6K1 , and this interaction is enhanced in mitotic cells . ^^^ These results suggest that Cdc 2 provides a signal that triggers inactivation of S6K1 in mitosis , presumably serving to spare energy for costly mitotic processes at the expense of ribosomal protein synthesis . . ^^^ |
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| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23443 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|