| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| MPF is a complex formed by the stoichiometric association of a 34 kd polypeptide previously identified as cdc 2 with a polypeptide that migrates with the same mobility as starfish cyclin in SDS PAGE ( apparent mol . wt 47 kd ) . ^^^ Since the apparent mol . wt of native starfish MPF was found to be less than 100 kd , it is a heterodimer comprising one molecule of cdc 2 and one molecule of cyclin B . . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| A 60 kd cdc 2 associated polypeptide complexes with the E1A proteins in adenovirus infected cells . p 60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor binding protein 5 , the homeobox gene Nkx 3 . 1 , the AR coactivator ARA 70 , and cell cycle genes Cdk 1 and Cdk 2 were androgen regulated in CWR 22 . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| Xenopus eggs contain two distinct cdc 2 homologs of 34 and 32 kd . ^^^ We show that the 32 kd cdc 2 protein , like the 34 kd protein , is a kinase . ^^^ However , unlike the 34 kd homolog , the 32 kd cdc 2 kinase activity does not decrease dramatically at the end of mitosis . ^^^ We also show that depletion of the 32 kd cdc 2 homolog from a Xenopus extract blocks DNA replication , but does not inhibit entry into mitosis . ^^^ By contrast , depletion of the 34 kd cdc 2 homolog or absence of mitotic cyclins from an extract does not inhibit replication , but does block entry into mitosis . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| We show here that a related 66 kd kinase , called mik 1 , acts redundantly with wee 1 in the negative regulation of cdc 2 in S . pombe . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| We have previously identified a cellular 35 kd protein associated with p 53 and now report evidence identifying this 35 kd protein as p34cdc2 , product of the cell cycle control cdc 2 gene . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| The clone MO 15 which codes for a 40 kd protein ( p40MO15 ) with 40 % amino acid identity to the human cdc 2 protein kinase has been isolated from a Xenopus cDNA library using a synthetic oligonucleotide probe . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| Quantitative immunoblotting of the column fractions with antibodies raised against p 34 , the product of the fission yeast cdc 2 gene , revealed complete coelution of the H1K activity and a 34 kd anti cdc 2 cross reactive protein . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| The 13 kd product of the suc 1 gene interacts with the cdc 2 kinase in yeast cells . ^^^ These findings suggest that the Xenopus cdc 2 protein and the 42 kd protein are components of MPF . . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| Both P 34 kD and P 36 kD kinases , similar to the S . pombe cdc 2 kinases , have been described to have activity as monomers . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| METHODS : The effects of olomoucine and bohemine were studied on the following parameters : ( 1 ) cell proliferation , by measurement of DNA content ; ( 2 ) viability , by the MTT ( 3 [ 4 , 5 dimethylthiazol 2 yl ] 2 , 5 diphenyltetrazolium bromide ) and / or XTT ( 2 , 3 bis [ 2 methoxy 4 nitro 5 sulfophenyl ] 2H tetrazolium 5 carboxanilide ) test ; and ( 3 ) the expression of p 53 , pRB , Bcl 2 , Bax , p 16 , p 21 , p 27 , cyclins A , B , D 1 , E , p 34 ( cdc 2 ) , and the androgen receptor ( AR ) , by western blot analysis . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| While AR depletion inhibited the expression of cyclin D 1 , cyclin B , and cdc 2 , ACTR depletion reduced the expression of cyclin E and cdk 2 . ^^^ |
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| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
|