| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| The level of cyclin B 1 , required for CDC 2 activity , was decreased in the presence of functional TP 53 . ^^^ Thus inhibition of PD 0166285 induced G ( 2 ) phase checkpoint abrogation by TP 53 was achieved at least in part through partial blockage of CDC 2 dephosphorylation of Tyr 15 and inhibition of cyclin B 1 expression . . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| Some kinases such as , cdc 2 may be increased in activity , which would explain the observed increased expression of tumor suppressor p 53 , the accumulation of the tumor cells in G 1 of the cell cycle and the inhibition of tumor cell proliferation . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| We demonstrate by western analysis that the expression levels of TP 53 ( formerly known as p 53 ) , CDKN1A ( formerly known as p21Waf1 ) , CDC 2 ( formerly known as p34cdc2 ) , CCNB 1 ( cyclin B 1 ) and RAD 51 are significantly modulated in confluent , density inhibited human diploid cell populations exposed to doses where only a small fraction of the nuclei are actually traversed by an alpha particle track . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the addition of supernatants from alpha irradiated cells to unirradiated cells decreases cellular levels of TP 53 and CDKN1A and increases CDC 2 and proliferating cell nuclear antigen in the latter . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| In addition , genistein enhanced the expression of the cell cycle inhibitor p 21 ( waf / cip1 ) by 10 to 15 fold , increased p 21 ( waf / cip1 ) association with Cdc 2 by 2 fold , and increased the expression of the tumor suppressor p 53 by 2 . 8 fold . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| Initiation of the transient arrest is TP 53 independent and is due to inhibitory phosphorylation of CDC 2 at Tyr 15 . ^^^ |
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| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|