| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| High selectivity toward a panel of nonreceptor tyrosine kinases ( c Src , 5 Abl and serine / threonine kinases ( PKC alpha , CDK 1 ) was observed . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Differential phosphorylation of c Abl in cell cycle determined by cdc 2 kinase and phosphatase activity . ^^^ Two interphase and all mitotic c Abl sites are phosphorylated by cdc 2 kinase isolated from either interphase or mitotic cells , with the mitotic cdc 2 having an 11 fold higher activity . ^^^ The differential phosphorylation of c Abl in the cell cycle is therefore determined by an equilibrium between cdc 2 kinase and protein phosphatase activities . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| The compound was selective toward other protein kinases : the Src IC 50 value was lower than those for Cdc 2 ( > 500 fold ) , epidermal growth factor ( EGF ) receptor ( 7 . 5 fold ) , and vascular endothelial growth factor receptor ( > 50 fold ) , and for 5 Abl ( 15 fold ) and focal adhesion kinase ( Fak ) ( > 25 fold ) . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Naturally occurring CA , CB , and CD showed inhibitory activity in kinase assays against the Ret / ptc1 and epidermal growth factor receptor ( EGF R ) tyrosine kinases , while being less effective against the 5 Abl tyrosine kinase and p 34 ( cdc 2 ) serine / threonine kinase ( IC ( 50 ) 2 . 8 , 5 . 5 , 81 . 3 , and 128 microM respectively , for the most potent compound CD ) . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Coadministration of flavopiridol and STI 571 did not result in changes in levels of expression of Bcl 2 , phopho Stat 5 , phospho p 34 ( cdc 2 ) , or Bcr / Abl . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Coadminstration of UCN 01 with U 0126 produced multiple perturbations in signal transduction / cell cycle regulatory pathways , including diminished expression of Bcr / Abl , Mcl 1 , cylin D ( 1 ) , and activation of JNK and p 34 ( cdc 2 ) . ^^^ |
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| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abi enhances Abl mediated CDC 2 phosphorylation and inactivation . ^^^ This finding led us to investigate the role of Abi in linking Abl and Cdc 2 . ^^^ The expression of Abi in cells greatly enhanced the formation of the Abl Cdc 2 complex , suggesting that Abi functions as an adaptor protein facilitating the binding between Abl and Cdc 2 . ^^^ We show that Abi promotes Abl mediated phosphorylation of Cdc 2 at tyrosine 15 and inactivation of Cdc 2 kinase activity . ^^^ These data suggest that Abl signaling may be involved in the downregulation of Cdc 2 kinase in cell cycle control . . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| Abnormal integrin mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation : BCR / ABL up regulates the cyclin dependent kinase inhibitor , p27Kip , which is relocated to the cell cytoplasm and incapable of regulating cdk 2 activity . beta ( 1 ) integrin engagement on normal ( NL ) CD 34 ( + ) cells increases levels of the cyclin dependent kinase inhibitor ( cdki ) , p 27 ( Kip ) , decreases cdk 2 activity , and inhibits G ( 1 ) / S phase progression . ^^^ |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06493 and P00519 |
Pubmed |
SVM Score :0.0 |
| NA |
|