| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the RNA expression of prothymosin alpha ( ProT alpha ) gene during rat development in several tissues and compared it to that of two proteins related to cell proliferation : proliferating cell nuclear antigen ( PCNA ) / cyclin and histone H 3 ( H 3 ) . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| It is shown that prothymosin alpha migrates to the nucleus at a rate comparable to that of histone H 1 . ^^^ |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha binds to histone H 1 in vitro . ^^^ We report here that purified ProT alpha binds specifically to histone H 1 in a dose dependent manner . ^^^ Polyglutamic acid , an analog of the central acidic domain of ProT alpha , strongly inhibits the above interaction , suggesting that the binding of ProT alpha to histone H 1 is mediated through its acidic domain . . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha ( PTA ) mRNA and histone H 4 ( H 4 ) mRNA levels were studied in various experimental conditions that affected GH 1 pituitary tumor cell proliferation . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Similarities between the histone binding patterns of Pro T alpha and of poly ( glutamic acid ) suggest that the observed histone binding capacity resides largely in the acidic central region of Pro T alpha . ^^^ However , all five histones were also bound by T alpha 1 ( a peptide corresponding to the first 28 amino acids of Pro T alpha ) ; histone binding by the N terminal region of Pro T alpha thus can not be ruled out . ^^^ In accordance with the observed capacity for histone binding , Pro T alpha ( in conjunction with ATP and some Pro T alpha binding factor / s in a thymocyte extract ) was able to induce in vitro nucleosome assembly . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Further analysis using COS cells lysed in the presence of sodium borohydride showed that : 1 ) phosphate recovered on prothymosin alpha decreased 8 fold when lysates were treated with borohydride ; 2 ) the reagent caused 4 8 glutamic acid residues / molecule to vanish ; 3 ) using [ 3H ] NaBH 4 , label was introduced into proline , a product derived from reductive cleavage of phosphoglutamate ; and 4 ) [ 3H ] proline was localized almost exclusively to a peptide with pronounced homology to the histone binding site of nucleoplasmin , a chromatin remodeling protein found in Xenopus laevis . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha modulates the interaction of histone H 1 with chromatin . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Modulation of histone acetyltransferase activity through interaction of epstein barr nuclear antigen 3C with prothymosin alpha . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| The effects of Zn2+ and Ca2+ on the interaction of prothymosin alpha with its putative partners , Rev of HIV type 1 and histone H 1 , were examined . ^^^ We demonstrated that Rev binds prothymosin alpha , and that prothymosin alpha binding to Rev but not to histone H 1 was significantly enhanced in the presence of zinc and calcium ions . ^^^ Our data suggest that the modes of prothymosin alpha interaction with Rev and histone H 1 are distinct and that the observed zinc and calcium binding properties of prothymosin alpha might be functionally relevant . . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha ( ProTalpha ) , a cellular molecule known to be associated with cell proliferation , is transcriptionally up regulated on expression of c myc and interacts with histones in vitro and associates with histone H 1 in cells . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| ProT alpha interacts with histone H 1 via its acidic domain , and its overexpression provokes the unfolding of chromatin fibers . ^^^ |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha ( ProTalpha ) is a histone H 1 binding protein localized in sites of active transcription in the nucleus . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Epstein Barr virus nuclear antigen 3C and prothymosin alpha interact with the p 300 transcriptional coactivator at the CH 1 and CH3 / HAT domains and cooperate in regulation of transcription and histone acetylation . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the RNA expression of prothymosin alpha ( ProT alpha ) gene during rat development in several tissues and compared it to that of two proteins related to cell proliferation : proliferating cell nuclear antigen ( PCNA ) / cyclin and histone H 3 ( H 3 ) . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| Prothymosin alpha ( ProTalpha ) is a histone H 1 binding protein that interacts with the transcription coactivator CREB binding protein and potentiates transcription . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| The involvement of ProT alpha in changes in the compaction state of chromatin has been recently elucidated with the demonstration that this protein induces the unfolding of chromatin fibres in a process that seems to be mediated by the interaction of ProT alpha with histone H 1 . ^^^ |
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| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q02539 and P06454 |
Pubmed |
SVM Score :0.0 |
| NA |
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