| Interacting proteins: Q9UQ80 and P06400 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 , an ErbB 3 binding protein , interacts with Rb and affects Rb transcriptional regulation . ^^^ We report that Rb is a binding target for Ebp 1 . ^^^ Ebp 1 was present in Rb immunoprecipitates derived from AU 565 breast cancer cells . ^^^ GST Rb also bound endogenous Ebp 1 . ^^^ Using GST Ebp 1 constructs , we determined that the 72 C terminal amino acids of Ebp 1 were sufficient to bind Rb . ^^^ |
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| Interacting proteins: Q9UQ80 and P06400 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 binds the tumor suppressor retinoblastoma protein ( Rb ) both in vivo and in vitro , and Rb and Ebp 1 cooperate to inhibit the transcription of the E2F1 regulated cyclin E promoter . ^^^ We show here that Ebp 1 can inhibit the transcription of other E2F regulated reporter genes and of several endogenous E2F regulated genes important in cell cycle progression in both Rb positive and Rb null cells . ^^^ |
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