| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.67725663 |
| Here we show that Che 1 contacts the Rb pocket region and competes with HDAC 1 for Rb binding site , removing HDAC 1 from the Rb / E2F complex in vitro and from the E2F target promoters in vivo . 0.67725663^^^ |
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| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.0 |
| Rb binding protein Che 1 interacts with Tau in cerebellar granule neurons . ^^^ |
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| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.0 |
| Identification of a novel partner of RNA polymerase 2 subunit 11 , Che 1 , which interacts with and affects the growth suppression function of Rb . hRPB 11 is a core subunit of RNA polymerase 2 ( pol 2 ) specifically down regulated on doxorubicin ( dox ) treatment . ^^^ In addition , we report that Che 1 interacts with the retinoblastoma susceptibility gene ( Rb ) by two distinct domains . ^^^ Functionally , we demonstrate that Che 1 represses the growth suppression function of Rb , counteracting the inhibitory action of Rb on the trans activation function of E2F1 . ^^^ These results identify a novel protein that binds Rb and the core of pol 2 , and suggest that Che 1 may be part of transcription regulatory complex . . ^^^ |
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| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that Che 1 inhibits the Rb growth suppressing function by interfering with Rb mediated HDAC 1 recruitment on E2F target gene promoters . ^^^ |
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| Interacting proteins: Q9NY61 and P06400 |
Pubmed |
SVM Score :0.0 |
| Genomic structure and transcriptional regulation of Che 1 , a novel partner of Rb . ^^^ We recently identified and cloned a novel human gene , Che 1 , whose product interacts with both RNA polymerase 2 and the retinoblastoma gene product ( Rb ) . ^^^ Furthermore , we found that Che 1 overexpression counteracts the growth inhibitory effects of Rb , regulating in such way both transcription and cell proliferation . ^^^ |
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