Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.72196228
CtIP was recently identified as a protein that associates with BRCA 1 and two other nuclear factors , CtBP 1 and Rb 1 . 0.72196228^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
Using a yeast two hybrid screen to identify proteins that specifically interact with the Rb related p 130 protein , we demonstrate that p 130 , as well as Rb , interacts with a protein known as CtIP . ^^^ This interaction depends on the p 130 pocket domain , which is important for repression activity , as well as an LXCXE sequence within CtIP , a motif previously shown to mediate interactions of viral proteins with Rb . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
Despite being a CtBP interactor , CtIP ' s association with Ikaros does not require CtBP but instead relies upon its Rb interaction domain . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
BRCA 1 , CtBP 1 , and Rb 1 associated CtIP and other candidates were found in a bioinformatic search combined with keywords related to cancer . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
CtIP interacts with a group of tumor suppressor proteins including RB ( retinoblastoma protein ) , BRCA 1 , Ikaros , and CtBP , which regulate cell cycle progression through transcriptional repression as well as chromatin remodeling . ^^^ Mouse NIH 3T3 cells depleted of Ctip were arrested at G ( 1 ) with the concomitant increase in hypophosphorylated Rb and Cdk inhibitors , p 21 . ^^^ However , depletion of Ctip failed to arrest Rb ( / ) mouse embryonic fibroblasts ( MEF ) or human osteosarcoma Saos 2 cells at G ( 1 ) , suggesting that this arrest is RB dependent . ^^^ Taken together , this finding uncovers a novel G ( 1 ) / S regulation in that CtIP counteracts Rb mediated G ( 1 ) restraint . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
Depletion of Ctip in established mouse embryo fibroblasts arrests cells in G 1 and results in an accumulation of hypophosphorylated Rb and the Cdk inhibitor p 21 , suggesting that CtIP is also a critical regulator of G1 / S transition of the cell cycle . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
CtIP activates its own and cyclin D 1 promoters via the E2F / RB pathway during G1 / S progression . ^^^ Here we show that in NIH 3T3 cells the expression of CtIP is regulated by the E2F / RB pathway during late G ( 1 ) and S phases . ^^^ The presence of wild type CtIP , but not the E157K mutant form , which failed to interact with RB , enhanced its own promoter activity . ^^^ Chromatin immunoprecipitation analysis indicated that the recruitment of CtIP to its promoter occurs concomitantly with TFIIB , a component of the RNA polymerase 2 complex , and with dissociation of RB from the promoter during late G ( 1 ) and G ( 1 ) / S transition . ^^^ Taken together , these results suggest that , contrary to the postulated universal corepressor role , CtIP activates a subset of E2F responsive promoters by releasing RB imposed repression and therefore promotes G ( 1 ) / S progression . . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
This new protein , which we call Rim , consists of 897 amino acids , has two leucine zipper motifs , and has a LECEE sequence previously identified as an RB binding domain . ^^^
Interacting proteins: Q99708 and P06400	Pubmed	SVM Score :0.0
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