| Interacting proteins: Q16665 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q16665 and P06400 |
Pubmed |
SVM Score :0.0 |
| Activation of RhoB by hypoxia controls hypoxia inducible factor 1alpha stabilization through glycogen synthase kinase 3 in U 87 glioblastoma cells . ^^^ This RhoB dependent degradation of hypoxia inducible factor 1alpha in hypoxic conditions was mediated by the Akt / glycogen synthase kinase 3beta pathway . ^^^ |
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| Interacting proteins: Q16665 and P06400 |
Pubmed |
SVM Score :0.0 |
| RESULTS : From a total of 345 screened TFs , 7 activity differential TFs were found , of which 5 showed increased activity , including p 53 , hypoxia inducible factor 1 alpha ( HIF 1alpha ) , signal transducer and activator of transcription 3 ( Stat 3 ) and Sp 1 , and 2 showed decreased activity including Rb and Smad 3 . ^^^ |
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| Interacting proteins: Q16665 and P06400 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that in human granulosa lutein cells the tumor suppressor genes RB 1 , VHL , NF 1 , NF 2 , Wt 1 , p 53 , and APC and the hypoxia dependent transcription factors HIF 1alpha , 2alpha , and 3alpha are expressed . ^^^ |
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