| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| We report here the identification of one such human cellular Rb associated protein of relative molecular mass 46 , 000 ( 46K ) ( RbAP 46 ) . ^^^ Two lines of evidence support the notion that RbAP 46 and simian virus 40 T antigen have homologous Rb binding properties : first , several mutated Rb proteins that failed to bind to T also did not associate with RbAP 46 ; and second , both T antigen and T peptide ( amino acids 101 118 ) were able to compete with RbAP 46 for binding to Rb . ^^^ The apparent targeting of the RbAP 46 Rb interaction by oncoproteins of DNA tumour viruses strongly suggests that formation of this complex is functionally important . . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Two closely related mammalian RB binding proteins , RbAp 48 and RbAp 46 , share sequence homology with the Msi 1 protein of yeast . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Induction of Rb associated protein ( RbAp 46 ) by Wilms ' tumor suppressor WT 1 mediates growth inhibition . ^^^ The gene was identified as retinoblastoma suppressor ( Rb ) associated protein 46 ( RbAp 46 ) , a nuclear protein that interacts physically with Rb and is a component of the human mSin 3 co repressor complex . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Here we report that BRCA 1 interacts in vivo and in vitro with the Rb binding proteins , RbAp 46 and RbAp 48 , as well as with Rb . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Unlike the other maize deacetylases , HD1A and nucleolar HD 2 , HD1B copurified as a complex with a protein related to the retinoblastoma associated protein , Rbap 46 . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Rb associated protein 46 ( RbAp 46 ) inhibits transcriptional transactivation mediated by BRCA 1 . ^^^ The retinoblastoma suppressor ( Rb ) associated protein 46 ( RbAp 46 ) is a member of the WD repeat protein family and a component of the histone modifying and remodeling complexes . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Consistent with this interpretation , the N terminal transcriptional repression domain of Suv39H1 bound the so called ' core histone deacetylase complex ' , composed of HDAC 1 , HDAC 2 and the Rb associated proteins RbAp 48 and RbAp 46 . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| We have found previously that the retinoblastoma ( Rb ) suppressor associated protein 46 ( RbAp 46 ) is a gene upregulated by the Wilms ' tumor suppressor , WT 1 , and functions as a potent growth inhibitor . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression of Rb associated protein 46 ( RbAp 46 ) reverts transformed phenotypes of breast cancer cells . ^^^ The retinoblastoma ( Rb ) suppressor associated protein 46 ( RbAp 46 ) is a subunit of chromatin modifying and remodeling complexes . ^^^ |
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| Interacting proteins: Q16576 and P06400 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The retinoblastoma ( Rb ) suppressor associated protein 46 ( RbAp 46 ) is a member of the WD repeat protein family and a component of histone modifying and remodeling complexes . ^^^ |
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