| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| RESULTS : While the following sixteen genes remained the unmethylated in all tumor and normal tissues : CDH 1 , APAF 1 , hMLH 1 , BRCA 1 , hTERC , VHL , RARbeta , TIMP 3 , DAPK 1 , SURVIVIN , p14ARF , RB 1 , p15INK4b , APC , RASSF1c and PTEN , varying degrees of tumor specific hypermethylation were associated with the p16INK4a , RASSF1a , CASP 8 and CDH 13 genes . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis , the methylation status of nine tumour suppressor genes ( TSGs : p 14 ( ARF ) , p 15 ( INK4B ) , p 16 ( INK4A ) , CASP 8 , MGMT , TIMP 3 , TP 73 , RB 1 and RASSF1A ) was assessed . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| The present objective was , for a sample of 27 children with intracranial EP and 7 with CPP , to describe and compare the methylation status of 19 genes ( with current HUGO symbol , if any ) : p15INK4a ( CDKN2B ) , p16INK4a and p14ARF ( both CDKN2A ) , APC , RB 1 , RASSF1A ( RASSF 1 ) , BLU ( ZMYND 10 ) FHIT , RARB , MGMT , DAPK ( DAPK 1 ) , ECAD ( CDH 1 ) , CASP 8 , TNFRSF10C , TNFRSF10D , FLIP ( CFLAR ) , INI 1 ( SMARCB 1 ) , TIMP 3 , and NF 2 . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| The frequencies of aberrant methylation were : 64 % for thrombospondin 1 ( THBS 1 ) ; 30 % for tissue inhibitor of metalloproteinase 3 ( TIMP 3 ) ; 27 % for O 6 methylguanine DNA methyltransferase ( MGMT ) ; 25 % for p 73 ; 18 % for RB 1 ; 14 % for death associated protein kinase ( DAPK ) , p14ARF , p16INK4a and caspase 8 , and 0 % for TP 53 and glutathione S transferase P 1 ( GSTP 1 ) . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| We have determined the methylation status of the CpG island of 11 tumour related genes ( RB 1 , p14ARF , p16INK4a , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 , caspase 8 , TP 53 and GSTP 1 ) in 18 neurofibromas ( including one plexiform neurofibroma ) and three neurofibrosarcomas , as well as two non neoplastic peripheral nerve sheath samples , using methylation specific polymerase chain reaction . ^^^ The incidence of aberrant methylation in the tumour samples was 52 % for THBS 1 , 43 % for MGMT , 33 % for TIMP 3 , 19 % each for p16INK4a and p 73 , 14 % for RB 1 , 5 % for p14ARF , and 0 % for DAPK , caspase 8 , TP 53 and GSTP 1 . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : We examined the DNA methylation status of 12 tumor related genes ( NF 2 , RB 1 , p 14 ( ARF ) , p 16 ( INK4a ) , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 , caspase 8 , TP 53 , and GSTP 1 ) in 44 sporadic and / or NF 2 associated schwannomas using methylation specific PCR . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| A ginseng saponin metabolite induced apoptosis in HepG 2 cells involves a mitochondria mediated pathway and its downstream caspase 8 activation and Bid cleavage . 20 O ( beta D glucopyranosyl ) 20 ( S ) protopanaxadiol ( IH 901 ) , an intestinal bacterial metabolite of ginseng saponin formed from ginsenosides Rb 1 , Rb 2 , and Rc , is suggested to be a potential chemopreventive agent . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| We determined the frequency of aberrant CpG island methylation of several tumor associated genes : p 16 ( INK4a ) , RB 1 , MGMT , DAPK , TIMP 3 , THBS 1 , TP 73 , NF 2 and Caspase 8 in a group of 27 ependymomas , consisting of 22 WHO grade 2 samples and five anaplastic WHO grade 3 tumors . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| Accordingly , we examined the DNA methylation status of ten tumor related genes ( RB 1 , p 16 ( INK4a ) , p 73 , MGMT , ER , DAPK , TIMP 3 , p 14 ( ARF ) , THBS 1 , and Caspase 8 ) in 98 meningiomas ( 68 grade 1 ; 27 grade 2 ; and 3 grade 3 samples ) using methylation specific PCR and sequencing . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Rb cells are resistant to DR mediated apoptosis because of a deficiency in caspase 8 expression secondary to epigenetic gene silencing by overmethylation . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| Loss of Rb E2F repression results in caspase 8 mediated apoptosis through inactivation of focal adhesion kinase . ^^^ Deregulation of the Rb E2F repressor complex by genetic deletion or functional inhibition of Rb triggers apoptosis through both the intrinsic ( caspase 9 mediated ) and extrinsic ( caspase 8 mediated ) death pathways . ^^^ This derepression of Rb E2F regulated genes leads to apoptosis through inactivation of focal adhesion kinase and activation of caspase 8 . ^^^ These findings reveal a new mechanistic link between Rb E2F and the extrinsic ( caspase 8 mediated ) apoptotic pathway . . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| The epigenetic changes in pituitary adenomas were identified by evaluating the methylation status of nine genes ( RB 1 , p 14 ( ARF ) , p 16 ( INK4a ) , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 and caspase 8 ) in a series of 35 tumours using methylation specific PCR analysis plus sequencing . ^^^ The frequencies of aberrant methylation were : 20 % for RB 1 , 17 % for p 14 ( ARF ) , 34 % for p 16 ( INK4a ) , 29 % for p 73 , 11 % for TIMP 3 , 23 % for MGMT , 6 % for DAPK , 43 % for THBS 1 and 54 % for caspase 8 . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| Inhibition of survivin by RNA interference reduced cell proliferation and induced apoptosis in Ishikawa cells by down regulating cyclin D 1 and phosphorylated RB and activating caspase 3 and caspase 8 . ^^^ |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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