Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
The CHR mutated promoter is activated by the E2F family of proteins ( E2F1 , E2F2 , E2F3 , and E2F4 ) but unable to be repressed by any of the Rb family members ( Rb , p 107 , and p 130 ) to the level of the wild type promoter activity in G 0 , indicating that the repression by the Rb family members is required for the corepressor element . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
In frozen tissue sections from liver metastases immunohistochemistry was performed with antibodies directed against p 53 , p 21 , E2F2 , Rb , Ki 67 and TS ( cell cycle related ) and bax , BCL 2 , BCL 10 , mcl 1 , PARP , caspase 3 , Fas receptor and Fas ligand ( apoptosis related ) . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
Therefore , we studied the cell cycle proteins , Rb , E2F2 , Ki 67 , p 21 and p 53 and the apoptotic proteins , mcl 1 , hax , bcl xl , bcl 2 , Fas receptor , Fas ligand , caspase 3 , M 30 and PARP as potential predictive factors . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
Specificity of E2F1 , E2F2 , and E2F3 in mediating phenotypes induced by loss of Rb . ^^^ Here , we report that E2F1 , E2F2 , and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency . ^^^ In the developing lens of Rb ( / ) embryos , loss of E2F1 , E2F2 , or E2F3 reduces the unscheduled proliferation of fiber cells , with the loss of E2F3 having the most pronounced effect . ^^^ In the central nervous system , loss of E2F1 or E2F3 can almost completely eliminate the ectopic DNA replication and apoptosis observed in Rb ( / ) embryos , and loss of E2F2 partially reduces the unscheduled DNA replication and has no effect on apoptosis . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
However , we found that specific E2F targets were not regulated in a consistent manner by the action of a RB allele that is refractory to cyclin dependent kinase / cyclin mediated phosphorylation ( PSM RB ) when compared with E2F2 overproduction . ^^^ Moreover , the relative action of RB versus E2F2 overexpression on specific genes demonstrates that a simple opposition model does not explain the relative contribution of RB to gene regulation . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
Silibinin treatments also resulted in an increase in the amount of Rb binding to E2F1 ( 3 . 8 fold ) , E2F2 ( 2 . 2 fold ) , and E2F3 ( 2 . 2 fold ) . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
While the three cloned species of E2F , E2F 1 , E2F 2 , and E2F 3 , are known to be targets of RB interaction , no E2F species has yet been shown to be a specific p 107 or p 130 target . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
The 2 . 2 A crystal structure of the Rb pocket complexed with an 18 residue transactivation domain peptide of E2F 2 reveals that the boomerang shaped peptide binds to the highly conserved interface between the A box and the B box of the Rb pocket in a bipartite manner . ^^^ The flexibility in the middle of the E2F 2 peptide is essential for the tight association of E2F to the Rb pocket . ^^^ The binding of Rb to the E2F 2 peptide conceals several conserved residues that are crucial for transcription activation of E2F . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
We have mutated Rb 1 in the mouse to express a protein ( R654W ) specifically deficient in binding E2F1 , E2F2 , and E2F3 . ^^^ R654W mutant embryos exhibit cell cycle defects the same as those of Rb 1 null embryos , reinforcing the importance of the interactions of pRb with E2F1 , E2F2 , and E2F3 for cell cycle control . ^^^ These data indicate that Rb 1 makes important cell type specific contributions to cellular differentiation that are genetically separable from its general ability to stably bind E2F1 , E2F2 , and E2F3 and regulate the cell cycle . . ^^^
Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: Q14209 and P06400	Pubmed	SVM Score :0.0
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