| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| A multiparametric analysis identified proteins associated with increased growth fraction ( Hdm 2 , p 53 , p 21 , Rb , cyclins A , B 1 , D 3 , and E , CDK 2 , CDK 6 , SKP 2 , Bcl 10 ( L ) , survivin , STAT 1 , and STAT 3 ) , and proteins associated with apoptosis ( NF kappaB , STAT 1 , and RB ) . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| We show that core protein suppresses the expression of tumor suppressor protein p 53 and cyclin dependent kinase ( CDK ) inhibitor p 21 and enhances the activation of cyclin dependent kinase 2 ( CDK 2 ) , the phosphorylation of retinoblastoma ( Rb ) , the activation of the transcription factor E2F 1 , and the expression of E2F 1 and S phase kinase interacting protein 2 ( SKP 2 ) genes . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| An Rb Skp 2 p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial penetrance Rb mutant . ^^^ Rb interacts with the N terminus of Skp 2 , interferes with Skp 2 p27 interaction , and inhibits ubiquitination of p 27 . ^^^ Disruption of p 27 function or expression of the Skp 2 N terminus prevents Rb from causing G 1 arrest . ^^^ A full penetrance , inactive Rb mutant fails to interfere with Skp 2 p27 interaction but , interestingly , a partial penetrance Rb mutant that is defective for E2F binding retains full activity in inhibiting Skp 2 p27 interaction and can induce G 1 cell cycle arrest with wild type kinetics . ^^^ These results identify an Rb Skp 2 p27 pathway in Rb function , which may be involved in inhibition of tumor progression . . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Rb phosphorylation and G 1 > S cell cycle progression by LXR ligands was reversed in VSMCs overexpressing Skp 2 , indicating that Skp 2 as an upstream regulator of p27Kip1 degradation plays a central role in LXR ligand mediated inhibition of VSMC proliferation . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| A recent kinetic study of this model further revealed that Rb represses Skp 2 to stabilize p 27 , which inhibits the kinase activity associated with cyclins E and A before the decline in their protein levels , to arrest the cell cycle . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| Indeed , inhibition of Skp 2 function with a dominant negative molecule reduces the ability of EBNA3C to degrade Rb . ^^^ Skp 2 has no detectable effect on Rb levels in the absence of EBNA3C , suggesting that SCF ( Skp 2 ) is specifically usurped by EBNA3C for the enhancement of Rb degradation . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| The EBV antigen EBNA3C regulates cell cycle by targeting critical cellular complexes such as cyclin A / cdk2 , SCF ( Skp 2 ) , and Rb . ^^^ |
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| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|