| Interacting proteins: P78396 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78396 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78396 and P06400 |
Pubmed |
SVM Score :0.0 |
| Functions of cyclin A 1 in the cell cycle and its interactions with transcription factor E2F 1 and the Rb family of proteins . ^^^ We report that cyclin A 1 could bind to important cell cycle regulators : the Rb family of proteins , the transcription factor E2F 1 , and the p 21 family of proteins . ^^^ Associations of cyclin A 1 with Rb and E2F 1 were observed in vivo in several cell lines . ^^^ When cyclin A 1 was coexpressed with CDK 2 in sf 9 insect cells , the CDK 2 cyclin A 1 complex had kinase activities for histone H 1 , E2F 1 , and the Rb family of proteins . ^^^ Our results suggest that the Rb family of proteins and E2F 1 may be important targets for phosphorylation by the cyclin A 1 associated kinase . ^^^ |
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| Interacting proteins: P78396 and P06400 |
Pubmed |
SVM Score :0.0 |
| Cyclin A 1 failed to mediate VEGF activation in DU 145 cells lacking a functional Rb and an androgen receptor ( AR ) . ^^^ However , induced coexpression of cyclin A 1 , Rb and AR in DU 145 cells in the presence of R 1881 greatly promoted VEGF promoter activity . ^^^ This suggests that cyclin A 1 mediates VEGF expression in cooperation with Rb and androgen dependent pathways in prostate cancer . . ^^^ |
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