| Interacting proteins: P62937 and P06400 |
Pubmed |
SVM Score :0.92342109 |
| The physical interactions between RB and CypA were demonstrated by glutathione S transferase affinity matrix binding assays and immunoprecipitation , followed by Western blot analyses . 0.92342109^^^ The N terminal region of CypA mediated the interaction with RB , whereas the region upstream of the A pocket of RB was required for binding to CypA . 0.51660443^^^ |
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| Interacting proteins: P62937 and P06400 |
Pubmed |
SVM Score :0.0 |
| Several cellular factors that complex with RB and exert their cellular regulatory functions have been identified , such as the RB : cyclophilin A ( CypA ) complex . 2 . ^^^ In this study , we used a model of neuronal differentiation to demonstrate that the nuclear translocation of CypA , the appearance of hypophosphorylated RB and the enhancement of RB : CypA complex formation correlates with retinoic acid induced neuronal differentiation . 4 . ^^^ Inhibition of CypA expression results in repression of both the hypophosphorylated RB and the neuron specific differentiation marker , class 3 beta tubulin . 5 . ^^^ The evidence of enriched CypA and colocalization of RB with CypA in the nucleus of primary adult sensory neurons substantiated the important event of RB mediated neuronal differentiation of p 19 EC cells . . ^^^ |
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