| Interacting proteins: P42575 and P06400 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^ |
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| Interacting proteins: P42575 and P06400 |
Pubmed |
SVM Score :0.0 |
| The association between RhoB and caspase 2 : changes with lovastatin induced apoptosis . ^^^ Because cytoskeletal actin is regulated , in part , by Rho , and because Rho and caspases are involved in apoptosis , we sought to determine whether there was an association between RhoB and caspase 2 . ^^^ A RhoB caspase 2 association was consistently demonstrated in neonatal mouse cardiomyocytes with Western Blotting , either after immunoprecipitation with RhoB followed by immunoblotting with caspase 2 , or in reciprocal experiments after immuno precipitation with caspase 2 and immunoblotting with RhoB ( n = 14 ) . ^^^ Although the RhoB caspase 2 complex was constitutively present , the link between RhoB and caspase 2 may be operative in apoptosis because the HMG CoA reductase inhibitor lovastatin increased the RhoB caspase complex , especially in the nuclear fraction of the cell , with a peak occurrence 2 h after treatment . ^^^ In summary , these data show a previously unrecognized association between RhoB and caspase 2 in the cytosolic and nuclear fractions , which has ramifications for processes regulated by RhoB and caspase 2 , including apoptosis . . ^^^ |
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| Interacting proteins: P42575 and P06400 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses were performed with specific antibody against BCL 2 , BCL XS / L , BAX , JUNB , c JUN , ICH 1L , c FOS , RB , CDK 2 , and p 53 . ^^^ |
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