| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| DMSO , sodium butyrate , and TPA induce hypophosphorylation of RB with HL 60 cell differentiation . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| SPase failed to degrade underphosphorylated RB present in TPA induced terminally differentiated HL 60 or U 937 cells . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| The expression of the protein products of the c myc oncogene and retinoblastoma susceptibility gene ( RB ) was investigated during either goat anti mouse immunoglobulin ( GaMIg ) or phorbol ester ( TPA ) induced growth arrest of the murine B lymphoma cell line WEHI 231 . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| The results of slot blot hybridizations showed that tumor promoter TPA induced c fos and c myc expressions in mouse fibroblast cell line BALB / 3T3 and rat liver , decreased the levels of Rb RNA in BALB / 3T3 cell line and of alpha 1 I 3 RNA in rat liver . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| In this region , there are sequences homologous to responding elements of P 53 , Rb , IL 1 , IL 6 , glucocorticoids , TPA and TGF beta . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Dihydroxy vitamin D 3 and 12 O tetradecanoyl phorbol 13 acetate synergistically induce monocytic cell differentiation : FOS and RB expression . 1 , 25 dihydroxy vitamin D 3 and 12 O tetradecanoyl phorbol 13 acetate ( TPA ) interact synergistically to induce monocytic differentiation of U 937 histiocytic lymphoma cells . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| The phorbol ester , 12 O tetradecanoylphorbol 13 acetate ( TPA ) , induced increased expression of the retinoblastoma ( RB ) tumor suppressor gene product in the course of megakaryocytic differentiation of the K 562 human leukemia cell line , a differentiatively multipotent hematopoietic precursor cell . ^^^ Furthermore , STSP caused an up regulation of RB expression similar to that caused by TPA . ^^^ Almost all of the RB protein is phosphorylated in untreated cells , but TPA and STSP both caused the late appearance of hypophosphorylated RB protein following cell cycle arrest . ^^^ The amount of RB protein per cell increased within hours of exposure to TPA or STSP and may have a role in the induced metabolic cascade producing the new phenotype . . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Both 1 , 25 ( OH ) 2D3 and TPA independently up regulated the vitamin D receptor , p 21 , and the hypophosphorylated form of retinoblastoma ( Rb ) protein . ^^^ In MCF 7D3Res cells , 1 , 25 ( OH ) 2D3 treatment had minimal effects on p 21 or Rb protein expression , whereas TPA down regulated Rb protein and transiently up regulated p 21 . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Furthermore , enforced overexpression of the DNA binding defective E2F1E132 mutant conferred TPA independence upon melanocytes and was associated with sequestration of Rb and constitutive expression of E2F1 target genes , including p21WAF1 / CIP1 . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Here we show a model of 12 o tetradecanoylphorbol 13 acetate ( TPA ) induced hematopoietic differentiation and growth arrest with a defective Rb mediated pathway . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| In comparison , the stimulation of Raf 1 by phorbol ester ( TPA ) activates the MAPK pathway , causes MAPK dependent p21WAF1 / CIP1 induction , Rb dephosphorylation and growth arrest without Bcl 2 phosphorylation or apoptosis . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Preventive effect of epicatechin and ginsenoside Rb ( 2 ) on the inhibition of gap junctional intercellular communication by TPA and H ( 2 ) O ( 2 ) . ^^^ The anticarcinogenic effects of epicatechin ( EC ) and ginsenoside Rb ( 2 ) ( Rb ( 2 ) ) , which are major components of green tea and Korea ginseng , respectively , were investigated using a model system of gap junctional intercellular communication ( GJIC ) in WB F 344 rat liver epithelial cells . 12 O tetradecanoylphorbol 13 acetate ( TPA ) and hydrogen peroxide , known as cancer promoters , inhibited GJIC in the epithelial cells as determined by the scrape loading / dye transfer assay , fluorescence redistribution assay after photobleaching , and immunofluorescent staining of connexin 43 using a laser confocal microscope . ^^^ The inhibition of GJIC by TPA and H ( 2 ) O ( 2 ) was prevented with treatment of Rb ( 2 ) or EC . ^^^ The effect of EC on GJIC was stronger in TPA treated cells than in H ( 2 ) O ( 2 ) treated cells , while the effect of Rb ( 2 ) was opposite to that of EC . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Both phases were inhibited to different degrees by NFA , glybenclamide and NPPB but DIDS was only effective on the peak phase . ( 86 ) Rb effluxes through both apical and basolateral membranes were stimulated by calcium , blocked by charybdotoxin , clotrimazole and TPA . 1 EBIO , a SK channel opener , stimulated ( 86 ) Rb effluxes . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Specificity of the polycation stimulated ( type 2A ) and ATP , Mg dependent ( type 1 ) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase . p34cdc2 kinase , a critical regulator of the cell cycle , has been shown to recognize the consensus sequence S / TP in proteins such as histone H 1 , the retinoblastoma gene product RB and the carboxyl terminal domain of eukaryotic RNA polymerase 2 . ^^^ |
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| Interacting proteins: P42166 and P06400 |
Pubmed |
SVM Score :0.0 |
| Pharmacokinetic parameters for SQ experiments were measured using the trapezoidal rule by plotting average plasma insulin level ( PIL ) vs . time and determining peak concentration ( CP ) , the time of peak concentration ( TP ) , duration of PIL curve ( D ) , and relative bioavailability ( RB ) . ^^^ |
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