Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of beta actin , EGFR , c cerbB 2 , MTS 1 , k ras , RB , BRCA 1 , cyclin E , and c myc genes . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
The genetics mutations affect at tumoral suppressors gen ( Gen RB 1 , p 53 , BRCA 1 , BRCA 2 ) and repressors gen ( hMSH 2 , hMLH 1 , . . . ) , they could be longer and multifocals mutations , and produce lack of cellular control and a greater predisposition to develop tumors and a probable risk of increment of radiosensitivity . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
The possible alarm signals include synthesis of poly ( ADP ribose ) polymers and initiation of phosphorylation cascades by kinases complexed with the DNA damage sensors , DNA PK and ATM ; the role of other factors is discussed , among them BRCA 1 and 2 , IRF 1 and RB ( retinoblastoma ) . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Here we report that BRCA 1 interacts in vivo and in vitro with the Rb binding proteins , RbAp 46 and RbAp 48 , as well as with Rb . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Loss of heterozygosity ( LOH ) analysis was performed using polymorphic microsatellite markers at sites of known tumor suppressor genes ( 17p [ p 53 ] , 13q [ Rb , BRCA 2 ] , 16q [ E cadherin ] , and 17q [ BRCA 1 ] ) and at chromosomes 3p , 6p , 6q , and 11q , which frequently are lost in cervical carcinoma . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
BRCA 1 associated growth arrest is RB dependent . ^^^ In cells with an intact rb gene , inactivation of pRb by HPV E 7 abrogates the growth arrest imposed by BRCA 1 . ^^^ In accordance with these observations , we found that BRCA 1 could not suppress BrdUrd uptake in primary fibroblasts from rb / mice and exhibited an intermediate ability to inhibit DNA synthesis in rb+ / as compared with rb+ / + cells . ^^^ Our data suggest that the growth suppressor function of BRCA 1 depends , at least in part , on Rb . . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Regulation of BRCA 1 expression by the Rb E2F pathway . ^^^ We now demonstrate that the product of the RB 1 gene , Rb , regulates the expression of the murine Brca 1 and human BRCA 1 genes through its ability to modulate E2F transcriptional activity . ^^^ The Brca 1 promoter contains E2F DNA binding sites that mediate transcriptional activation by E2F1 and repression by Rb . ^^^ The human BRCA 1 promoter also contains a conserved E2F site and is similarly regulated by E2F1 and Rb . ^^^ This functional link between the BRCA 1 and Rb tumor suppressors may provide insight into the mechanism by which BRCA 1 inactivation contributes to cancer development . . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Retinoblastoma susceptibility protein , Rb , possesses multiple BRCT Ws , BRCA 1 carboxyl terminus related W regions with DNA break binding activity . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Rb associated protein 46 ( RbAp 46 ) inhibits transcriptional transactivation mediated by BRCA 1 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
It was shown that BRCTs of TopBP 1 , BRCA 1 , and BRCT Ws of Rb bound DNA ends and breaks . ^^^ These results suggest the common presence of DNA binding motifs that can recognize DNA ends or damages in major tumor suppressors , Rb , BRCA 1 and p 53 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Disruption of BRCA 1 LXCXE motif alters BRCA 1 functional activity and regulation of RB family but not RB protein binding . ^^^ The tumor suppressor activity of the BRCA 1 gene product is due , in part , to functional interactions with other tumor suppressors , including p 53 and the retinoblastoma ( RB ) protein . ^^^ RB binding sites on BRCA 1 were identified in the C terminal BRCT domain ( Yarden and Brody , 1999 ) and in the N terminus ( aa 304 394 ) ( Aprelikova et al . , 1999 ) . ^^^ The N terminal site contains a consensus RB binding motif , LXCXE ( aa 358 362 ) , but the role of this motif in RB binding and BRCA 1 functional activity is unclear . ^^^ In both in vitro and in vivo assays , we found that the BRCA 1 : RB interaction does not require the BRCA 1 LXCXE motif , nor does it require an intact A / B binding pocket of RB . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Using an antibody specific to the hyperphosphorylated form of Rb , we detected the inactive protein only in the pigment epithelial cells of the iris . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
METHODS : We simultaneously analyzed methylation and expression profiles of five putative tumor suppressor genes ( p 15 , p 16 , Rb , BRCA 1 , and E cadherin ) in 14 different cell lines using bisulfite genomic sequencing and reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Ectopic expression of BRCA 1 leads to decrease of the Rb protein and Cyclin D 1 protein . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
To test this hypothesis , we examined whether ER alpha positive and Ki 67 positive tumors showed differences in ( 1 ) pathological grade , ( 2 ) three indices of tumor grade ( tubule formation , nuclear pleomorphism , and mitotic number ) , and ( 3 ) expression of important proteins implicated in breast tumorigenesis ( cyclin D 1 , ErbB 2 , ATM , BRCA 1 , Rb , p 53 , and p 21 ) . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
CtIP interacts with a group of tumor suppressor proteins including RB ( retinoblastoma protein ) , BRCA 1 , Ikaros , and CtBP , which regulate cell cycle progression through transcriptional repression as well as chromatin remodeling . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
We describe a prolonged G 1 cell cycle arrest associated with a decrease in the hyperphosphorylated form of Rb , suggesting that the Rb / E2F pathway is implicated in BRCA 1 induced cell growth arrest . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Expression changes of 10 mRNAs of interest ( AR , Rb , ARA 160 , ARA 24 , ARA 54 , ARA 55 , ARA 70 , BRCA 1 , F SRC 1 , and RAC 3 ) were analyzed simultaneously as AR and AR associated cofactors in 1 hybridization reaction . ^^^ Only Rb , ARA 55 and BRCA 1 were not detected . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
These included several markers linked to known tumor suppressor genes ( TP 53 , APC , DCC , RB 1 , and BRCA 1 ) . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
By these means we have excluded involvement of Rb 1 and BRCA 1 on chromosomes 13q and 17q respectively . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Examples include the RB 1 gene for retinoblastoma ; the WT 1 gene for Wilms ' tumor ; germline p 53 mutations in families with the Li Fraumeni syndrome ; the NF 1 and NF 2 genes for neuroblastomatosis , types 1 and 2 ; the VHL gene for renal cancer and other tumors associated with Von Hippel Lindau disease ; the APC gene for adenomatous polyposis coli ; the BRCA 1 gene for hereditary breast and ovarian cancer ; and the mismatch repair genes for colon and other common cancers . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
METHODS : The authors assessed the LOH of the 10 known tumor suppressor genes ( VHL , APC , EXT 1 , WT 1 , Rb 1 , p 53 , BRCA 1 , nm 23 , DPC 4 , and DCC ) with microsatellite markers in 29 consecutively resected HCC specimens . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
BACKGROUND : The recent literature of familial cancer , specifically related to germline mutations of RB 1 , p 53 , NF 1 , ATM , BRCA 1 , Mismatch repair genes and APC is reviewed . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
We suggest that FAA is hypermutable , and that slipped strand mispairing , a mutational mechanism recognized as important for the generation of germ line and somatic mutations in a variety of cancer related genes , including p 53 , APC , RB 1 , WT 1 , and BRCA 1 , may be a major mechanism for FAA mutagenesis . . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Designs were generated for the RB 1 , TP 53 , MLH 1 and BRCA 1 genes that can be readily implemented in research and clinical laboratories as low cost genetic screening tests . . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
The highest frequency of loss , 84 % ( 86 of 102 cases ) , was observed for markers mapping near or within BRCA 1 ; other significant frequencies of LOH were observed for loci mapping near or within CDKN2A / CDKN2B ( 56 % ) , BRCA 2 ( 61 % ) , RB 1 ( 67 % ) , or TP 53 ( 73 % ) . ^^^ LOH of CDKN 2 without loss near the BRCA 1 region was seen in only 2 of 75 cases ( P < 0 . 0001 ) , and RB 1 LOH without BRCA 1 loss occurred in only 1 of 35 tumors ( P = 0 . 0703 ) . ^^^ These data suggest that LOH of BRCA 1 , or a closely linked locus , precedes the loss of CDKN 2 , TP 53 , and RB 1 , and imply that inactivation of a tumor suppressor gene in this region is an important early step in the development of these tumors . . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
CtIP was recently identified as a protein that associates with BRCA 1 and two other nuclear factors , CtBP 1 and Rb 1 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
RB 1 , ki ras ) and `` caretakers ' ' ( e . g . hMLH 1 and hMSH 2 , BRCA 1 ) . ^^^ At present , the most useful methods of risk assessment are those performed on the following genes : BRCA 1 and BRCA 2 especially for hereditary breast and ovarian cancer , hMLH 1 and hMSH 2 for hereditary non polyposis colorectal cancer , APC for familial adenomatous polyposis , ret for medullary thyroid carcinoma , p 53 for the Li Fraumeni syndrome , p 16 for melanoma and RB 1 for retinoblastoma . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
BRCA 1 , CtBP 1 , and Rb 1 associated CtIP and other candidates were found in a bioinformatic search combined with keywords related to cancer . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
RESULTS : While the following sixteen genes remained the unmethylated in all tumor and normal tissues : CDH 1 , APAF 1 , hMLH 1 , BRCA 1 , hTERC , VHL , RARbeta , TIMP 3 , DAPK 1 , SURVIVIN , p14ARF , RB 1 , p15INK4b , APC , RASSF1c and PTEN , varying degrees of tumor specific hypermethylation were associated with the p16INK4a , RASSF1a , CASP 8 and CDH 13 genes . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
We studied the methylation status of E cadherin , CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , RASSF1A , RARB , and GSTP 1 by use of TGCT tissues and testicular malignant lymphoma tissues ( 25 primary TGCT tissues and three primary testicular lymphoma tissues ) . ^^^ Methylation was not observed in E cadherin , CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , RASSF1A , RARB , and GSTP 1 in any of the TGCT tissues . ^^^ In contrast , all three ( 100 % ) of the testicular lymphoma tissues demonstrated hypermethylation of E cadherin , RASSF1A , and RARB , but not CDKN2B , CDKN2A , BRCA 1 , RB 1 , VHL , and GSTP 1 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
The past 15 years has seen the establishment of mouse lines heterozygous or homozygous null for genes known or suspected of being involved in human cancer syndromes , including APC , ATM , BLM , BRCA 1 , BRCA 2 , LKB 1 , MEN 1 , MLH , MSH , NF 1 , TP 53 , PTEN , RB 1 , TSC 1 , TSC 2 , VHL , and XPA . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
RESULTS : Seventeen genes ( ABL , APC , APAF 1 , BRCA 1 , CSPG 2 , DAPK 1 , hMLH 1 , LKB 1 , PTEN , p14ARF , p15INK4b , p27KIP1 , p57KIP2 , RASSF1C , RB 1 , SURVIVIN , and VHL ) displayed a uniformly unmethylated pattern in all the astrocytoma and non astrocytoma tissues examined . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Downregulated genes included tumor suppressor genes ( RB 1 , BRCA 1 , BS 69 ) and the genes related to cell proliferation control . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
METHODS : For this purpose , we performed a comparative analysis of the frequency of deletions of BRCA 1 , BRCA 2 , BRCAX , TP 53 , ATM , and RB 1 and amplification of Cyclin D 1 and also studied the interrelation and prognostic significance of these genetic alterations in 30 early onset ( < or =40 years ) and 33 late onset ( > 40 years ) cases of BC . ^^^ RESULTS : A differential pattern of alterations ( deletion / amplification ) was observed in the two age groups , with the sequence in younger women being BRCA 1 ( 72 % ) , TP 53 ( 71 % ) , ATM ( 64 % ) , BRCA 2 ( 62 % ) , RB 1 ( 60 % ) , Cyclin D 1 ( 43 % ) , and BRCAX ( 24 % ) and that in the older group being TP 53 ( 66 % ) , RB 1 ( 63 % ) , BRCA 1 ( 56 % ) , ATM ( 53 % ) , BRCA 2 ( 45 % ) , Cyclin D 1 ( 24 % ) , and BRCAX ( 23 % ) . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Some markers were intragenic for BRCA 1 , BRCA 2 , BRCAX , ATM , TP 53 , and RB 1 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
METHODS : We employed reverse transcription and real time fluorescent PCR to quantify the expression of nine genes ( BRCA 1 , BRCA 2 , ATM , TP 53 , RB 1 , MAD 2 , BUB 1 , APC and beta actin ) in oocytes and embryos . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Rb 1 protein binds both TOP 2 and BRCA 1 in intact cells , and pRb is required for association between TOP 2 and BRCA 1 . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
Methylation was detected in 5 of 16 genes ( NF 2 , p 14 ( ARF ) , CDH 1 , BRCA 1 , RB 1 ) previously shown to be silenced in a variety of tumour types . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
The different genes involved in the BRCA 1 and BRCA 2 pathways ( GADD45A , BARD 1 , JUN , BAX , RB 1 , ERalpha , ERbeta , BAP 1 , TNFalpha , p 53 , p21Waf1 / Cip1 , p 300 , RAD 51 , pS 2 , Ki 67 ) were quantified by real time quantitative RT PCR , using the TaqMan method and an ABI Prism 7700 Sequence Detector ( Applied Biosystems ) . ^^^
Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P38398	Pubmed	SVM Score :0.0
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