| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.64491117 |
| Prohibitin , a potential tumor suppressor , interacts with RB and regulates E2F function . 0.64491117^^^ |
|
| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| For many others , such as MYC , CCND 1 , EMS 1 , EGF , RB 1 , NME , DCC and prohibitin , the evidence is still largely circumstantial , or obtained only by in vitro studies on breast cancer cell lines . ^^^ |
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| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals . ^^^ We recently observed that prohibitin , a potential tumor suppressor protein , binds to the retinoblastoma ( Rb ) protein and represses E2F transcriptional activity . ^^^ Agents such as E1A , p 38 kinase , and cyclins D and E had no effect on prohibitin mediated repression of E2F1 , but all of these molecules could reverse Rb function . ^^^ Similarly , stimulation of the immunoglobulin M signaling pathway in Ramos cells could inactivate prohibitin , but this had no effect on Rb function . ^^^ Serum stimulation of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics ; further , while the serum dependent inactivation of Rb was dependent on cyclin dependent kinase activity , the inactivation of prohibitin was not . ^^^ |
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| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| We recently reported that a potential tumor suppressor , prohibitin , which interacts with retinoblastoma protein ( Rb ) , regulates E2F function and this activity correlates with its growth suppressive activity . ^^^ Although prohibitin associates with , and recruits , Brg 1 and Brm independently of Rb , prohibitin / Brg 1 / Brm mediated transcriptional repression requires Rb . ^^^ |
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| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of Rb family proteins and prohibitin during camptothecin induced apoptosis . ^^^ These growth regulatory functions of prohibitin require a physical interaction with the Rb protein . ^^^ It thus appears that prohibitin may be inhibiting apoptosis by downregulating E2F activity when Rb family members are inactive . . ^^^ |
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| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| Prohibitin co localizes with Rb in the nucleus and recruits N CoR and HDAC 1 for transcriptional repression . ^^^ The potential tumor suppressor protein prohibitin can prevent cell proliferation and this required its binding to the Rb protein . ^^^ Here we show that a subset of prohibitin molecules are present in the nucleus where it co localizes with the Rb protein . ^^^ Our experiments show that a 53 amino acid stretch of E2F1 is sufficient for being targeted by prohibitin ; fusion of this region to GAL 4 VP16 construct could make it susceptible to prohibitin mediated , but not Rb mediated repression . ^^^ Prohibitin , like Rb , could repress transcription from SV 40 and major late promoters when recruited directly to DNA . ^^^ |
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| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| We had shown previously that prohibitin could bind to the Rb protein as well as E2F and this binding was necessary to suppress cell proliferation . ^^^ |
|
| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35232 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|