| Interacting proteins: P29375 and P06400 |
Pubmed |
SVM Score :0.87685044 |
| One of the major mechanisms leading to RB dysfunction is complex formation with viral oncoproteins using the common RB binding motif Leu 10 Cys 10 Glu ( LXCXE ) which has also been identified in cellular ligands , e . g . , RBP 1 and RBP 2 . p 107 , a cellular protein with RB sequence homology , has been shown to bind to the same viral oncoproteins associating with RB and is therefore thought to contribute to cell cycle regulation . 0.87685044^^^ |
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| Interacting proteins: P29375 and P06400 |
Pubmed |
SVM Score :1.2113294 |
| Although Rbp 2 has been shown to interact with RB , p 107 , TATA binding protein , and T cell oncogene rhombotin 2 , the physiological function of Rbp 2 remains unclear . 1.2113294^^^ |
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| Interacting proteins: P29375 and P06400 |
Pubmed |
SVM Score :0.0 |
| Homology analysis indicated that the predicted product has an overall 56 % amino acid identity to RBBP 2 , which plays an important role in RB tumor suppressor regulation . ^^^ |
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| Interacting proteins: P29375 and P06400 |
Pubmed |
SVM Score :0.0 |
| Differential specificity for binding of retinoblastoma binding protein 2 to RB , p 107 , and TATA binding protein . ^^^ To study the functional role of these interactions , we examined the properties of cellular retinoblastoma binding protein 2 ( RBP 2 ) binding to RB , p 107 , and the related TATA binding protein ( TBP ) product . ^^^ We observed that although RBP 2 bound exclusively to the T / E1A pocket of p 107 , it could interact with RB through independent T / E1A and non T / E1A domains and with TBP only through the non T / E1A domain . ^^^ Consistent with this observation , we found that a mutation within the Leu 10 Cys 10 Glu motif of RBP 2 resulted in loss of ability to precipitate p 107 , while RB and TBP binding activities were retained . ^^^ We located the non T / E1A binding site of RBP 2 on a 15 kDa fragment that is independent from the Leu 10 Cys 10 Glu motif and encodes binding activity for RB and TBP but does not interact with p 107 . ^^^ |
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| Interacting proteins: P29375 and P06400 |
Pubmed |
SVM Score :0.0 |
| In a search for proteins that can improve the survival of Chk 1 deficient cells exposed to DNA damage , we identified fission yeast Msc 1 , which is homologous to a mammalian protein that binds to the tumor suppressor Rb ( RBP 2 ) . ^^^ |
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