| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.96580841 |
| One of the major mechanisms leading to RB dysfunction is complex formation with viral oncoproteins using the common RB binding motif Leu 10 Cys 10 Glu ( LXCXE ) which has also been identified in cellular ligands , e . g . , RBP 1 and RBP 2 . p 107 , a cellular protein with RB sequence homology , has been shown to bind to the same viral oncoproteins associating with RB and is therefore thought to contribute to cell cycle regulation . 0.96580841^^^ |
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| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.0 |
| The RBP 1 gene encodes a widely expressed 200 kDa nuclear protein and undergoes alternative splicing that predicts a family of RB binding peptides . . ^^^ |
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| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.0 |
| Thus repression of E2F dependent transcription by RBP 1 via RB family members may play a central role in inducing growth arrest . . ^^^ |
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| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.0 |
| A known RB binding protein , RBP 1 , was previously found by our group to be an active corepressor which , if overexpressed , represses E2F mediated transcription via its association with the pocket . ^^^ Thus , RB family members repress transcription by recruiting RBP 1 to the pocket . ^^^ |
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| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.0 |
| Such enzymes do not interact directly with RB family proteins but rather utilize RBP 1 to target the pocket . ^^^ We also show that in quiescent normal human cells this entire RBP 1 mSIN3 SAP 30 HDAC complex colocalizes with both RB family members and E2F4 in a limited number of discrete regions of the nucleus that in other studies have been shown to represent the initial origins of DNA replication following growth stimulation . ^^^ These results suggest that RB family members , at least in part , drive exit from the cell cycle by recruitment of this HDAC complex via RBP 1 to repress transcription from E2F dependent promoters and possibly to alter chromatin structure at DNA origins . . ^^^ |
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| Interacting proteins: P29374 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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