| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Neither MEK inhibitor PD 98059 nor p 38 kinase inhibitor SB 203580 blocked stimulation of rhoB by UVC ( UV light , 254 nm ) which indicates that ERK or p 38 mitogen activated protein ( MAP ) kinase are not involved in the UV induction of rhoB . ^^^ The data provide evidence both for a signal transduction pathway independent of JNK , ERK , and p 38 MAP kinase to be involved in the induction of rhoB by genotoxic stress , and furthermore , indicate autoregulation of rhoB . . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Retinoic acid ( RA ) activated the extracellular signal regulated kinase ( ERK ) 2 mitogen activated protein kinase ( MAPK ) of HL 60 human myeloblastic leukemia cells before causing myeloid differentiation and cell cycle arrest associated with hypophosphorylation of the retinoblastoma ( RB ) tumor suppressor protein . ^^^ G 0 growth arrest and RB tumor suppressor protein hypophosphorylation ( which is typically associated with induced differentiation and G 0 arrest ) , two putatively RB regulated processes , also depended on ERK 2 activation by MEK . ^^^ Activation of ERK 2 by RA occurred within hours and persisted until the onset of RB hypophosphorylation , differentiation , and arrest . ^^^ The results thus show that RA augments MEK dependent ERK 2 activation that is needed for subsequent RB hypophosphorylation , cell differentiation , and G 0 arrest . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| In HL 60 human myeloblastic leukemia cells , retinoic acid is known to cause cFMS , RAF , MEK , and ERK 2 dependent myeloid cell differentiation and G 0 arrest associated with RB tumor suppressor protein hypophosphorylation , implicating receptor tyrosine kinase signal transduction in propelling these retinoic acid induced cellular effects . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that both RhoB F and RhoB GG inhibit anchorage dependent and independent growth , induce apoptosis , inhibit constitutive activation of Erk and insulin like growth factor 1 stimulation of Akt , and suppress tumor growth in nude mice . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Since PD 98059 blocks the cFMS conferred enhancement of the retinoic acid induced differentiation , but not growth arrest , the data indicate that cFMS enhanced differentiation acts primarily through MEK and ERK 2 , but cFMS enhanced G1 / 0 arrest allied with RB hypophosphorylation depends on another cFMS signal route , which by itself can effect G1 / 0 arrest without activated ERK 2 . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| To evaluate the role of the MEK / ERK pathway in NSCLC survival , we analyzed NSCLC cell lines that differed in tumor histology and status of p 53 , Rb , and K ras . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Loss of Rb overrides the requirement for ERK activity for cell proliferation . ^^^ Here we report that whereas wild type ( Wt ) mouse embryo fibroblasts ( MEFs ) depend on ERK activation to enter the cell cycle , Rb deficient ( Rb ( / ) ) MEFs have a reduced requirement for ERK signalling . ^^^ Analysis of Rb deficient tumour cell lines also revealed a reduced requirement for ERK signalling in asynchronous growth . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| In addition , blockade of ERK / MAPK signaling with PD 98059 strongly inhibited phosphorylation of the retinoblastoma protein ( Rb ) and activity of a luciferase reporter plasmid driven by multiple E2F elements . ^^^ Inhibition of mitogen induced MCM 6 and MCM 7 expression by PD 98059 was reversed by ectopic overexpression of E2F , indicating that ERK / MAPK signaling is required for events that occur upstream of E2F release from phosphorylated Rb . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of the cells with the PKC inhibitors and ERK inhibitor blocked PTH inhibition of ( 86 ) Rb uptake , Na ( + ) , K ( + ) ATPase activity , alpha ( 1 ) subunit phosphorylation , and endocytosis in WT and S18A cells . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Rb Ser ( 795 ) peaked at 10 min , lagging behind phosphorylation of MEK and ERK ( extracellular signal regulated protein kinase ) . ^^^ Rb Ser ( 795 ) phosphorylation could be blocked by PD 98059 , a MEK inhibitor , and greatly attenuated by apigenin , an inhibitor of the Ras > Raf > MEK > ERK pathway . ^^^ These studies show a rapid , novel , and selective phosphorylation of Rb Ser ( 795 ) by mitogens and demonstrate an unexpected rapid linkage between the actions of the Ras > Raf > MEK > ERK pathway and the phosphorylation state of Rb . . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| The ability of integrins to induce the activation of EGFR and its subsequent regulation of Erk and Akt activation permitted adhesion dependent induction of cyclin D 1 and p 21 , Rb phosphorylation , and activation of cdk 4 in epithelial cells in the absence of exogenous growth factors . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Cerivastatin reduced the 3H thymidine incorporation ( 164 + / 11 % , p < 0 . 01 ) , inhibited Cdk 2 activation and Rb phosphorylation , but did not prevent p27Kip1 down regulation , nor p42mapk and p70S6K activation . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| The effect of PG 1 on proliferation was determined by measuring activity of Ras , ERK , Rb , [ ( 3 ) H ] thymidine incorporation , and cell cycle analysis . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| This led to the hypothesis that TH , acting through increased type 5 somatostatin receptor , could activate the ERK pathway leading to cAMP response element binding protein dependent decreased expression of critical cell cycle proteins , specifically cyclin A , resulting in hypophosphorylation of Rb and its subsequent arrest of S phase progression . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Previous studies in fibroblasts have shown that the pol 3 specific transcription factor IIIB ( TFIIIB ) is bound and regulated by the proto oncogene product c Myc , the mitogen activated protein kinase ERK and the retinoblastoma tumour suppressor protein , RB . ^^^ The principal function of TFIIIB is to recruit pol 3 to its cognate gene template , an activity that is known to be inhibited by RB and stimulated by ERK . ^^^ However , hypoxic conditions cause TFIIIB dissociation from c Myc and ERK , at the same time as increasing its interaction with RB . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Additionally , suppression of beta arrestin also blocked activation of Src , suppressed levels of phosphorylated ERK , and abrogated Rb Raf 1 binding in response to nicotine . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| Using HL 60 human myeloblastic leukemia cells , a cell line that undergoes G 0 cell cycle arrest and myeloid differentiation in response to retinoic acid ( RA ) , tazarotene failed to cause extracellular signal regulated kinase ( ERK ) activation , a requirement for retinoic acid ( RA ) induced G 0 arrest and differentiation ; retinoblastoma ( RB ) hypophosphorylation , another characteristic of RA induced G 0 arrest and cell differentiation ; G 0 arrest ; or differentiation into mature myeloid cells . ^^^ However , when used in combination with a retinoid 10 receptor ( RXR ) selective ligand , tazarotene caused ERK activation , RB tumor suppressor protein hypophosphorylation , G 0 arrest , and myeloid differentiation . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| The activation of ERK 1 / 2 and Akt as induced by stimulation with epidermal growth factor ( EGF ) or platelet derived growth factor ( PDGF ) was inhibited by 1O2 generated intracellularly upon photoexcitation of rose Bengal ( RB ) . ^^^ |
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| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| The purified pseudopodial fraction contains phosphotyrosinated proteins , including Met and FAK , and various signaling proteins , including Raf 1 , MEK 1 , ERK 2 , PKBalpha ( Akt 1 ) , GSK3alpha , GSK3beta , Rb , and Stat 3 . ^^^ |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|