| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| We investigated the status and expression of p 16 , p 15 , CCND 1 , CDK 4 and RB genes in the Ewing family of tumors . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Southern blot hybridization was used to detect the rearrangement and amplification of five proto oncogenes ( bcl 2 , bcl 1 , c myc , c myb and c Ha ras ) and one tumor suppressor gene ( RB 1 ) in 55 Japanese patients with non Hodgkin ' s lymphoma ; 16 with T cell lymphomas and 39 with B cell lymphomas ( 7 follicular and 32 diffuse lymphomas ) . ^^^ No abnormalities were found in RB 1 , bcl 1 , and Ha ras . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Forty four B chronic lymphocytic leukemias ( CLL ) were studied by Southern blot analysis using probes for the Ig genes and bcl 1 , bcl 2 ( major , minor and 5 ' breakpoint region ) , bcl 3 , c myc , and retinoblastoma ( Rb ) loci . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Southern blot hybridization analysis failed to show evidence of bcl 1 , bcl 2 , c myc proto oncogene or retinoblastoma ( Rb ) tumor suppressor gene rearrangements in these six cases of Richter ' s syndrome . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| For many others , such as MYC , CCND 1 , EMS 1 , EGF , RB 1 , NME , DCC and prohibitin , the evidence is still largely circumstantial , or obtained only by in vitro studies on breast cancer cell lines . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| In the glioblastomas with no alterations of CDKN2A , CDK 4 or RB 1 , several other genes ( CCND 1 , CCND 2 , CCND 3 , CDK 6 , E2F , CDK 7 , MYC and MYCN ) whose products take part in cell cycle regulation were examined . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| The following markers were selected on their putative role in the process of metastasis and were studied using immunohistochemical and / or Southern blot techniques : proliferating cell nuclear antigen ( PCNA ) , p 53 , retinoblastoma tumor suppressor gene ( Rb ) , myc , bcl 2 ( inhibitor of apoptosis ) , epidermal growth factor ( EGF ) , EGF receptor ( EGFR ) , neu , nm 23 ( also known as NME 1 , putative metastasis suppressor ) , desmoplakin , neuron cell adhesion molecule ( N CAM ) , epithelial cell adhesion molecule ( Ep CAM ) , E cadherin , cyclin D 1 ( CCND 1 ) , and EMS 1 . ^^^ RESULTS : The presence of an inflammatory reaction surrounding the tumor ( P = . 07 ) , eosinophilic infiltration ( P = . 16 ) , positive immunostaining for Rb ( P = . 02 ) , negative immunostaining for Ep CAM ( P = . 13 ) , and amplification of CCND 1 and EMS 1 ( P = . 05 ) correlated with nodal metastasis . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of CCND 1 and RB 1 in resection margin epithelia of lung cancer patients . ^^^ This study was carried out to examine cyclin D 1 ( CCND 1 ) and retinoblastoma ( RB 1 ) gene expression in the bronchial epithelium of patients with lung cancer . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Cyclin D 1 ( CCND 1 ) and retinoblastoma ( Rb ) genes are cell cycle regulators which are altered in some breast carcinomas . ^^^ However , the possible cooperation between CCND 1 and Rb , as well as the influence and coincidence of their abnormalities in the proliferative capacity of mammary carcinoma cells in vivo , is still unknown . ^^^ In order to assess both the significance of the CCND 1 gene and Rb alterations in breast carcinomas and their relationship with the proliferative capacity of the tumours and other clinico pathological factors , CCND 1 mRNA expression was studied in 46 cases of primary breast carcinomas and matched normal tissue , 45 of which were also studied immunohistochemically , Rb expression was analysed in the same cases by immunohistochemistry , whereas the proliferative activity of the carcinoma was evaluated by flow cytometry . ^^^ This abnormality was significantly associated with increased mean S phase ( P = 0 . 017 ) and decreased CCND 1 mRNA expression in non overexpressed tumours , supporting in vivo the postulated regulatory loop between Rb and CCND 1 in vitro . ^^^ We conclude that CCND 1 up regulation is not associated with increased proliferative activity in breast carcinomas , whereas its expression might be regulated in vivo by hormones and Rb . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Twenty primary central nervous system lymphomas ( PCNSL ) from immunocompetent patients ( nineteen B cell lymphomas and one T cell lymphoma ) were investigated for genetic alterations and / or expression of the genes BCL 2 , CCND 1 , CDK 4 , CDKN1A , CDKN2A , MDM 2 , MYC , RB 1 , REL , and TP 53 . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| To investigate whether alteration of other components in pRb pathway is an alternative mechanism underlying the development of these chemically induced lymphomas , we have examined the genetic status of Rb 1 , Ccnd 1 and Cdk 4 genes that encode retinoblastoma protein , cyclin D 1 and cyclin dependence kinase 4 , respectively . ^^^ Gross alterations of the Rb 1 , Ccnd 1 , and Cdk 4 genes were not detected by Southern analysis in any of the tumors examined . ^^^ These results indicate that the mechanisms underlying the development of 2 ' , 3 ' dideoxycytidine and 1 , 3 butadiene induced lymphomas involve inactivation of p16 / p15 cyclin dependent kinase inhibitors but not genomic alterations of the Rb 1 , Ccnd 1 and Cdk 4 genes . . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| FISH analysis of gene aberrations ( MYC , CCND 1 , ERBB 2 , RB , and AR ) in advanced prostatic carcinomas before and after androgen deprivation therapy . ^^^ Fluorescence in situ hybridization ( FISH ) analysis of dissociated nuclei with DNA probes for MYC ( 8q24 ) / # 8 , cyclin D 1 gene ( CCND 1 ; 11q13 ) / # 11 , ERBB 2 ( 17q13 ) / # 17 , the androgen receptor gene ( AR ; Xq 12 ) / # 10 , and the retinoblastoma gene ( RB ; 13q14 ) was applied to formalin fixed tissue from 63 patients with advanced PC after androgen deprivation therapy ( ADT ) ; matched tumor tissue before ADT was also available in 22 of these cases . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| The genes associated with bladder carcinogenesis include oncogenes ( such as H ras , FGFR 3 , erbB 2 , CCND 1 , mdm 2 ) , tumor suppressor genes ( such as INK4A / ARF , Rb , TP 53 , PTEN , TSC 1 , PTCH , DBCCR 1 ) , and DNA mismatch repair genes , etc . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| We were able to demonstrate cyclin D 1 overexpression but could detect neither amplification of the CCND 1 gene nor allelic loss at chromosomes 9p22 21 and 13q ( surrounding the genes p 16 and Rb , respectively ) . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Differential alterations of the genes in the CDKN2A CCND 1 CDK4 RB 1 pathway are associated with the development of head and neck squamous cell carcinoma in Indian patients . ^^^ RESULTS : The alterations [ mutation , hypermethylation , homozygous deletion and loss of heterozygosity / microsatellite size alteration ( LOH / MA ) ] in the CDKN2A were found to be highest in 57 % of the samples , followed by CCND 1 amplification and LOH / MA at the RB 1 locus in 14 % and 8 . 5 % of the samples , respectively . ^^^ Comparatively high frequency of CDKN2A alterations ( except homozygous deletion ) was found in dysplastic head and neck lesions and remained almost constant or increased during progression of the tumour , whereas the homozygous deletion of CDKN2A and the alterations in CCND 1 and RB 1 genes were seen mainly in the later stages of the tumour . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Following the subcloning of the promoter regions into a gene reporter system , we found that at least four promoter haplotypes associated with CCND 1 , E2F1 , HDAC 1 and RB 1 significantly influenced transcriptional activity in an allele specific manner . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Many mechanisms may be responsible for activating the RB Cyclin D 1 pathway , including activating ( CDK 4 ) and inactivating mutations ( p16INK4A ) , deletions ( RB and p16INK4A ) , amplifications ( CCND 1 and CDK 4 ) , silencing methylation ( p16INK4A and RB ) , and hyper phosphorylation ( RB ) . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Heterogeneous abnormalities of CCND 1 and RB 1 in primary cutaneous T Cell lymphomas suggesting impaired cell cycle control in disease pathogenesis . ^^^ However , little is known about the abnormalities of CCND 1 and its regulator RB 1 in primary cutaneous T cell lymphomas ( CTCL ) . ^^^ Affymetrix revealed increased gene expression of CCND 2 in four of eight CTCL cases , CCND 3 in three cases , and CDKN2C in two cases with a normal expression of CCND 1 and RB 1 . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Oncogenes ( H ras , erbB 2 , EGFR , MDM 2 , C MYC , CCND 1 ) , tumor suppressor genes ( p 53 , Rb , p 21 , p27 / KIP1 , p 16 , PTEN , STK 15 , FHIT , FEZ1 / LZTS1 , bc 10 ) , telomerase , and methylation have all been studied in bladder cancer . ^^^ |
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| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| A variety of tumor suppressor genes ( including p 53 , APC , DCC and Rb ) and proto oncogenes ( including prad 1 , EGFR , c erb 2 and TGF alpha ) may be involved in the development and progression of esophageal cancer . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| PRAD 1 complexes to the product of the retinoblastoma ( Rb ) tumor suppressor gene , an event followed by Rb inactivation . ^^^ The role of PRAD 1 as a cell cycle regulatory gene and its interactions with the Rb tumor suppressor gene suggests that PRAD 1 deregulation may be a significant molecular event in the evolution of these tumors . . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| Because the PRAD 1 , or cyclin D 1 , gene , a cell cycle regulator , has been implicated in a subgroup of benign parathyroid tumors , we examined the possibility that another cell cycle regulator with possible functional links to PRAD 1 , the retinoblastoma tumor suppressor gene ( RB ) , might be involved in the molecular pathogenesis of parathyroid carcinoma . ^^^ |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24385 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|