| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| These mutations also inhibited ATF 2 stimulated gene expression mediated by the retinoblastoma ( Rb ) tumor suppressor and the adenovirus early region 1A ( E1A ) oncoprotein . ^^^ |
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| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| Since the human Rb gene promoter also contains an ATF 2 like binding site , we examined whether pRb can regulate its own expression through ATF 2 . ^^^ We have also determined that the carboxyl terminal domain of pRb is responsible for the Rb autoinduction through ATF 2 . ^^^ |
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| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| Rb represses some genes by sequestering or inactivating the positive transcription factor E2F and seems to activate some others by interacting with factors like Sp 1 or ATF 2 . ^^^ |
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| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| The retinoblastoma protein ( Rb ) also activates this promoter and enhances the stimulatory effects of ATF 2 but causes near extinction of the effects of ATFa . ^^^ Immunoprecipitation with Rb antibodies of lysates from transfected cells brings down expressed ATF 2 but not ATFa . ^^^ ATF 2 antibodies bring down expressed Rb , JNK and p 38 and expression of Rb enhances the immunoprecipitation of both JNK and p 38 by ATF 2 antibodies . ^^^ The results suggest that Rb is acting as a matchmaker by bridging either JNK or p 38 with their common substrate ATF 2 and , hence , facilitating its activation . ^^^ Consistent with this suggestion , expression of Rb enhances the phosphorylation of ATF 2 in CHO cells . . ^^^ |
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| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| At 48 h after stress , ATF 2 starts to interact with hypophosphorylated Rb , which allows the biomarkers of stress induced senescence like phenotype to appear . ^^^ |
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| Interacting proteins: P15336 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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