| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Na+ / H+ exchange ( NHE ) subtypes has been investigated in a study of the mouse fibroblast L cell line ( LAP 1 ) transfected with human ( h ) NHE 1 , rabbit ( rb ) NHE 2 , rat ( rt ) or human ( h ) NHE 3 as well as an opossum kidney cell line ( OK ) and porcine renal brush border membrane vesicles ( BBMV ) . ^^^ |
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| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| We propose that T antigen disrupts Rb E2F family complexes through the action of its J domain and Hsc 70 . ^^^ These findings indicate how Hsc 70 supports T antigen action and help to explain the cis requirement for a J domain and Rb binding motif in T antigen induced transformation . ^^^ Furthermore , this is the first demonstration linking Hsc 70 ATP hydrolysis to the release of E2F bound by Rb family members . . ^^^ |
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| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| In contrast to the effect on DNA replication , the L13V substitution in large T antigen did not prevent complex formation with Hsc 70 and the Rb protein . ^^^ |
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| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we identified seven proteins co immunoprecipitating with Rb in this tumor , including Lamin A / C and six proteins not previously reported to bind Rb : Hsc 70 , high mobility group protein 1 ( HMG 1 ) , hnRPN , glyceraldehyde 3 phosphate dehydrogenase ( G3PDH ) , EF 1 , and EF 2 . ^^^ |
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| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| This suggests that E2F1 could be a substrate for Hsc 70 recruited by T antigen to an Rb family member . ^^^ Importantly , our results strengthen the chaperone hypothesis for E2F release from an Rb family member by Hsc 70 recruited by large T antigen . ^^^ That is , it now appears that Hsc 70 can freely access helix 3 and the HPD motif of large T antigen bound to an Rb family member . . ^^^ |
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| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06400 and P11142 |
Pubmed |
SVM Score :0.0 |
| NA |
|