| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.91241847 |
| Thus , AP 2 , through its physical and functional interaction with Rb , may contribute to the cell cycle regulation of its target genes . . 0.91241847^^^ Importantly , in contrast to the majority of Rb binding proteins , the C terminal domain of Rb alone is sufficient for its interaction with AP 2 . 0.79061874^^^ |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| RB and c Myc activate expression of the E cadherin gene in epithelial cells through interaction with transcription factor AP 2 . ^^^ In vitro AP 2 and RB interaction involves the N terminal domain of AP 2 and the oncoprotein binding domain and C terminal domain of RB . ^^^ In vivo physical interaction between RB and AP 2 was demonstrated in MDCK and HaCat cells . ^^^ In LT transformed MDCK cells , LT , RB , and AP 2 were all coimmunoprecipitated by each of the corresponding antibodies , and a mutation of the RB binding domain of the oncoprotein inhibited its binding to both RB and AP 2 . ^^^ Taken together , our results suggest that there is a tripartite complex between LT , RB , and AP 2 and that the physical and functional interactions between LT and AP 2 are mediated by RB . ^^^ |
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| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| Large T antigen ( LT ) expressed by the oncogenic DNA virus SV 40 transforms cells by interacting with and perturbing the normal function of several important cellular proteins including P 53 , RB , c MYC , and AP 2 . ^^^ Recently LT and AP 2 were shown to interact at the protein level in vivo and this interaction appeared to mediated by the RB protein . ^^^ |
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| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| E cadherin expression was previously shown to be activated by RB and c myc specifically in epithelial cells , through interaction with the AP 2 transcription factor . ^^^ |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that YY 1 , acting as a transcription factor binding to its site on the promoter , or through protein protein interaction with AP 2 , may be part of a regulatory network including key cell cycle regulators such as c Myc and Rb in controlling growth and differentiation regulated gene expression . . ^^^ |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| While we can not detect direct association of CDP with Rb in vitro , we discover that CDP can bind AP 2 , a ubiquitous factor that interacts with Rb . ^^^ |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| The distribution of WRNp and the expression of the transcription factors regulating WRN gene expression SP 1 , AP 2 , and retinoblastoma protein ( Rb ) were studied in the various human organs by immunohistochemical and immunoblot analyses . ^^^ |
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| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| By monitoring protein DNA interactions in living cells using formaldehyde cross linking and chromatin immunoprecipitation , we show that endogenous RB and AP 2 both bind to the same bcl 2 promoter sequence . ^^^ In addition , we demonstrate that RB and AP 2 also bind to the E cadherin gene promoter in vivo , consistent with regulation of this promoter by both AP 2 and RB in epithelial cells . ^^^ |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05549 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|