| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| Here we show that PAI 2 has a novel intracellular function as a retinoblastoma protein ( Rb ) binding protein . ^^^ PAI 2 colocalized with Rb in the nucleus and inhibited the turnover of Rb , which led to increases in Rb protein levels and Rb mediated activities . ^^^ Although PAI 2 contains an LXCXE motif , Rb binding was primarily mediated by the C D interhelical region of PAI 2 , which was found to bind to the C pocket of Rb . ^^^ The C D interhelical region of PAI 2 contained a novel Rb binding motif , termed the PENF homology motif , which is shared by many cellular and viral Rb binding proteins . ^^^ PAI 2 expression also protected Rb from the accelerated degradation mediated by human papillomavirus ( HPV ) E 7 , leading to recovery of Rb and inhibition of E6 / E7 mRNA expression . ^^^ |
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| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| The serine protease inhibitor SerpinB 2 ( PAI 2 ) , a major product of differentiating squamous epithelial cells , has recently been shown to bind and protect the retinoblastoma protein ( Rb ) from degradation . ^^^ Here we illustrate that PAI 2 expression in the HPV 18 transformed cervical carcinoma line HeLa resulted in the restoration of Rb expression , which led to the functional silencing of transcription from the HPV 18 URR . ^^^ In contrast to HeLa cells , where the C / EBPbeta YY 1 dimer binds this site , in PAI 2 and / or Rb expressing cells the site was occupied by the dominant negative C / EBPbeta isoform liver enriched transcriptional inhibitory protein ( LIP ) . ^^^ PAI 2 expression thus has a potent suppressive effect on HPV 18 oncogene transcription mediated by Rb and LIP , a finding with potential implications for prognosis and treatment of HPV transformed lesions . . ^^^ |
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| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| PAI 2 has been linked to protection from TNF alpha induced apoptosis , and a stabilizing interaction with the retinoblastoma protein ( Rb 1 ) has been proposed . ^^^ |
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| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| Finally , target genes and proteins situated on the downstream pathway of p 53 transcription appears to be the most important factors of growth acceleration or even cell dissemination in lung cancer ( Rb and its phosphorylation pathway , Bax Bc 12 balance and matrix degrading enzymes UPA and inhibitor PAI ) . ^^^ |
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| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05120 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|