Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
If both RB 1 and TP 53 are involved in the initiation of osteosarcoma , the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
By the PCR SSCP analysis of DNAs from surgical specimens of human cancers , mutated ras genes ( 17 % ) and aberrations of tumor suppressor p 53 gene ( 53 % ) including loss of one of the two alleles and a mutation in the remaining allele were detected in lung carcinomas and aberrations of both of the p 53 and retinoblastoma ( RB ) genes were detected exclusively in advanced hepatocellular carcinomas . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We demonstrated that the phosphoprotein p 53 and RB product can be immunolocalized on routine histological material . p 53 protein was absent in all typical and atypical carcinoids , while it was abnormally expressed in eight SCLC and one borderline case . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The ability of the oncogene products of DNA tumor viruses to induce DNA synthesis in quiescent cells is thought to depend on their capacity to bind to cellular proteins such as the retinoblastoma suppressor protein Rb and the tumor suppressor p 53 , thereby abolishing the growth arresting properties of these proteins . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Deletions of one copy of the RB and TP 53 genes are less frequent as are mutations of the TP 53 gene , and accumulating evidence suggests the presence of an additional tumour suppressor gene on chromosome 17p , which is frequently inactivated in prostate cancer . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
On the basis of Western immunoblot analysis of Rb , p 53 and cell cycle inhibitory protein ( Cip 1 ) ( p 21 ) proteins , TNF alpha decreased Rb protein expression in a dose and time dependent manner whereas it increased the expression level of tumor suppressor p 53 protein . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The increase in copy number at 8q24 ( MYC ) and decreases at 17p13 ( TP 53 ) , 13q14 ( RB ) , and 3p have previously been identified in SCLC with other methods . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In addition , the high rate and mutation pattern of TP 53 and RB in primary tumors have rendered them prototype tumor suppressor genes . ^^^ Furthermore , detection of TP 53 and RB mutations and altered expression of their encoded products appear to be of clinical significance , often correlating with prognosis , when identified in specific cancers . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We studied three GCT cell lines and 44 tumors for loss of heterozygosity ( LOH ) of the tumor suppressor genes APC , MCC , DCC , RB , TP 53 , and WT 1 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Frequent loss of heterozygosity for Rb , TP 53 , and chromosome arm 3p , but not NME 1 in squamous cell carcinomas of the supraglottic larynx . ^^^ Allelic losses were frequent at TP 53 ( 56 % of the tumors ) , the retinoblastoma gene ( Rb , 59 % ) , and the p 13 14 region of chromosome 3 ( 64 % ) . ^^^ The high frequencies of allelic loss at TP 53 , Rb , and 3p13 14 suggest that these suppressors play a major role in laryngeal carcinogenesis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In the present study , we examined the sufficiency of SV 40 T antigen ( Tag ) binding to pRB and p 53 to substitute for alterations in RB and TP 53 at all stages of human uroepithelial cell ( HUC ) transformation in vitro . ^^^ These results indicate that Tag / pRB and Tag / p53 binding apparently abrogate requirements for / or a selective advantage of RB and TP 53 mutations in HUC tumorigenic transformation and progression , as well as in HUC immortalization . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Deletions of one copy of the RB gene are common , whereas deletion and / or point mutation of the TP 53 gene is a less frequent event , at least in clinically localized tumours . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Alterations in p 53 and pRb , products of the chromosomes 17p13 TP 53 and 13q14 RB tumor suppressor genes , occur in approximately 50 % and approximately 33 % of bladder cancers respectively , and are associated with later stage , higher grade disease . p 53 and pRb alterations are also known to occur in early stage bladder carcinoma in situ where they are thought to represent a poor prognosis for tumor progression . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Although overexpression of these protooncogenes might inhibit growth regulation through the TP 53 and retinoblastoma tumor suppressor protein ( RB ) mediated pathways , neither gene was included consistently in all of the amplicons observed in our sarcoma panel . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Recent studies have shown that inactivation of certain tumor suppressor genes , such as RB and TP 53 , occur in bladder tumors that have a more aggressive clinical outcome and poor prognosis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
A family of genes has been characterized that follows this `` two hit ' ' model including the two prototype suppressors genes : the retinoblastoma ( RB ) and the TP 53 ( also known as p 53 ) genes . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The prototype suppressor genes are the retinoblastoma ( RB ) gene and the TP 53 ( also known as p 53 ) genes . ^^^ Recent studies have shown that inactivation of TP 53 and RB occur in bladder tumors that have a more aggressive clinical outcome and poor prognosis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The cell cycle regulatory genes classified as tumour suppressors , TP 53 and RB , maintain genomic stability and inhibit cancer through their roles in preserving cell cycle checkpoints . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Also in bladder carcinoma the study of cellular differentiation markers has been replaced by that of genotypic alterations , and , mainly with the help of immunohistochemistry , of the expression of genes involved in cell proliferation and death , such as MTS 1 , TP 53 , Rb , c myc , Bcl 2 , c erb B 2 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The frequency of mutations within glioma associated TSG , such as TP 53 and RB , suggests that defects in TGFbeta ' s inhibitory signaling pathway may have analogous effects in the progression to HD GM , and TGFbeta ' s conversion to a mitogen . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
LOH on 3p , 9p , 13q , 17p and 18q occurred mainly within the loci of the VHL , CDKN 2 , Rb , TP 53 and DCC tumour suppressor genes respectively . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Point mutations in exon 1 of KRAS and in exon 7 of TP 53 were evident by polymerase chain reaction ( PCR ) DNA sequencing in the RAL cell line , whereas no alterations were present in the HRAS and RB genes . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These new markers include DNA ploidy , S phase , certain monoclonal antibodies , the p 53 ( alias TP 53 ) tumor suppressor gene , the retinoblastoma ( Rb ) gene , cell adhesion molecules , and angiogenesis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
A series of molecular changes including loss of heterozygosity ( LOH ) at 17p ( TP 53 gene ) , 13q ( RB gene ) , 18q ( DCC gene ) , and 9p21 ( CDKN2a gene ) chromosomal regions have been identified in dysplasias , carcinomas in situ , and invasive carcinomas of the gallbladder , whereas mutations in K and N ras genes are rare . ^^^ We determined the presence of mutations in TP 53 , K and N ras genes , and LOH at five chromosomal regions ( 5q22 APC MCC region , RB , TP 53 , DCC and 9p21 CDKN2a ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We determined loss of heterozygosity ( LOH ) at 10 chromosomal regions ( 3p12 , 3p14 . 2 , 3p14 . 1 21 . 3 , 3p21 , 3p22 24 , 3p25 , 5q22 , 9p21 , 13q14 RB , and 17p13 TP 53 ) frequently deleted in lung cancer , using 31 polymorphic microsatellite markers , including 24 that spanned the entire 3p arm . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Markers near RB , DCC , BBC 1 , TP 53 and at D13S325 ( 13q21 22 ) showed higher loss rates in grades 2 and 3 ( between 25 % and 44 . 4 % ) compared with grade 1 ( 0 6 . 6 % ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Aberrant expression of the cell cycle associated proteins TP 53 , MDM 2 , p 21 , p 27 , cdk 4 , cyclin D 1 , RB , and EGFR in cervical carcinomas . ^^^ OBJECTIVE : The aims of this study were to study aberrant expression and coexpression of the cell cycle associated proteins TP 53 , p 21 , p 27 , cyclin D 1 , cdk 4 , RB , EGFR , and MDM 2 in cervical carcinomas , to correlate protein alterations with histopathological and clinical parameters , and to evaluate whether these alterations provide prognostic information . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
METHODS : Loss of heterozygosity ( LOH ) at seven 3p chromosomal regions ( 3p12 , 3p14 . 2 , 3p14 . 3 21 . 1 , 3p21 . 3 , 3p22 24 , 3p24 . 3 , 3p25 ) , 13q14 ( RB ) and 17p13 . 1 ( p 53 ) loci , and TP 53 gene mutations in microdissected archival tissues were investigated . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In this regard , it is noteworthy that most of the altered genes act upon the two recognized critical growth and senescence pathways , TP 53 and RB . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Inactivation of the P 16 ( INK4A ) / retinoblastoma ( RB ) or TP 53 biochemical pathway is frequent event in most human cancers . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Hha 1 digested and undigested samples were used to study the methylation pattern of androgen receptor alleles and undigested samples were used for microsatellite analysis of TSG ( TP 53 , RB 1 , WT 1 , and NF 1 ) . ^^^ From the latter group , 9 cases expressed more genetic changes in the deep compartment ( involving TP 53 gene in all cases , WT 1 gene in 2 , and NF 1 in 1 ) , whereas in 4 cases the superficial compartment showed more genetic changes ( three involving NF 1 and one involving both RB and TP 53 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In several human cancer cell lines , RhoA promotes focus formation whereas RhoB is as potent as the tumor suppressor p 53 at inhibiting transformation in this assay . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
TP 53 alterations in relation to the cell cycle associated proteins p 21 , cyclin D 1 , CDK 4 , RB , MDM 2 , and EGFR in cancers of the uterine corpus . ^^^ In the present study , TP 53 alterations have been analysed and compared with the expression of the proteins p 21 , cyclin D 1 , cdk 4 , RB , EGFR , and MDM 2 in 53 cancers of the uterine corpus . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The IHC markers used were chosen to provide a broad representation of various aspects of tumour biology , i . e . the androgen receptor ( AR ) and oestrogen receptor ( ER ) , adhesion molecules ( E cadherin ) , proliferation markers ( MIB 1 ) , tumour suppressor genes ( TP 53 and the retinoblastoma gene product , Rb ) and other novel cancer related proteins ( cyclin D 1 and the breast cancer susceptibility gene product , BRCA 2 ) . ^^^ TP 53 , Rb , AR and BRCA 2 were of limited prognostic value . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The transduction of exogenous TP 53 or Rb genes in p 53 defective myoblasts rescues MyoD activity and differentiation potential . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In this regard , it is noteworthy that many of the genes that are altered act upon the two recognized critical growth and senescenc pathways , TP 53 and RB . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
TCC progression correlates with genetic instability and accumulation of collaborative genetic lesions mainly involving TP 53 , retinoblastoma ( RB ) 1 , and growth factors . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Rb and TP 53 pathway alterations in sporadic and NF 1 related malignant peripheral nerve sheath tumors . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These tumors invariably showed inactivation of Rb and Trp 53 . ^^^ Remarkably , loss of Rb in photoreceptor cells does not lead to retinoblastoma or any phenotypic changes , not even when photoreceptor cells are made deficient in Rb , p 107 and Trp 53 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Mutation analysis of the tumor suppressor genes showed that Y ML 1B is inactivated in TP 53 and RASSF1A , but not in p 14 ( ARF ) , p 16 ( INK4A ) , or RB . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In addition , regulation of the G ( 2 ) checkpoint by the tumor suppressor p 53 is RB dependent . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Importance of TP 53 and RB in the repair of potentially lethal damage and induction of color junctions after exposure to ionizing radiation . ^^^ Repair of potentially lethal damage ( PLD ) was investigated in cells with functional G 1 phase arrest with wild type TP 53 and wild type RB and in cells in which G 1 phase arrest was abrogated by inactivation of TP 53 or RB . ^^^ Significant repair of PLD was found in cells carrying both wild type TP 53 and wild type RB . ^^^ In cells in which TP 53 or RB was inactivated , the survival curves from immediately plated and delayed plated cells were not significantly different . ^^^ From this study we conclude that a functional G 1 phase arrest is important for repair of PLD and that TP 53 and RB do not affect the frequencies of induction of color junctions in chromosome 18 or 19 . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The initiation of this TP 53 dependent G 1 phase arrest occurs despite the presence of substantial levels of cyclin D1 / CDK4 and cyclin E / CDK2 kinase activities , hyperphosphoryated RB , and active E2F1 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The genes associated with bladder carcinogenesis include oncogenes ( such as H ras , FGFR 3 , erbB 2 , CCND 1 , mdm 2 ) , tumor suppressor genes ( such as INK4A / ARF , Rb , TP 53 , PTEN , TSC 1 , PTCH , DBCCR 1 ) , and DNA mismatch repair genes , etc . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
TP14ARF and TP16INK4a play important roles in the TP 53 and RB tumor suppressor pathways , respectively . ^^^ Unlike a mutually exclusive relationship for inactivation between TP16INK4a and RB , TP14ARF and TP 53 did not show such a relationship ( P = 0 . 61 , Fisher exact test ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Because of the close relationship between p 14 ( ARF ) and TP 53 and between p 15 ( INK4b ) / p16 ( INK4a ) and Rb , these results support a model of a coinactivation of TP 53 and Rb pathways in 75 % of MPNSTs , with functional consequences on cell growth control and apoptosis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These results strongly suggest that AxdAdB 3 possesses a wider therapeutic potential than previously believed , given that most pancreatic cancers have abnormalities in both the TP 53 and RB pathways . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We analyzed samples from 29 patients and found molecular alterations of the RB and TP 53 genes in 6 ( 21 % ) and 3 ( 10 % ) cases , respectively . ^^^ Hence , in the pathogenesis of human OS , deregulation of the G1 / S checkpoint genes , especially RB , TP 53 , and INK4 / ARF locus , plays an important role and defines a subgroup of patients with a poor outcome . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Viral E 6 and E 7 oncogenes are key mediators in cell transformation by disrupting TP 53 and RB pathways . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We thus set out to assess how recurrent patterns of genetic injury at three critical human melanoma loci CDKN2A , TP 53 , and CDK 4 cooperate to disrupt both RB and p 53 pathways . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Frequency of chromosomal aneuploidies and deletions of the RB and TP 53 genes in MALT lymphomas harboring the t ( 14 ; 18 ) ( q 32 ; q 21 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Deletions of the 3p chromosome region and molecular alterations of the tumor suppressor genes RB 1 and TP 53 , located , respectively , at 13q14 and 17p13 , are well documented in small cell lung cancer ( SCLC ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB 1 and TP 53 . ^^^ A malignant stromal tumor of the testis with an osteosarcoma component and five of its metastases mainly containing osteosarcoma have been analyzed for RB 1 and TP 53 abnormalities . ^^^ Whereas in the primary tumor and in some of the metastases loss of heterozygosity could not be detected for RB 1 or for the 17p13 region in which TP 53 is located , other metastases showed such losses of heterozygosity . ^^^ Therefore , in this case neither RB 1 nor TP 53 seems to play an essential role in the initiation of osteosarcoma . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These genes include 1 ) those important to androgen metabolism in the prostate , the androgen receptor and steroid 5 alpha reductase genes ; 2 ) those that map to the 10q ( PLAU ) and 7q ( MET ) chromosomal regions found deleted in some prostate carcinomas , and 3 ) proto oncogenes ( ERBB 2 , INT 2 , and MYC ) and tumor suppressor gene loci ( RB 1 , TP 53 and D17S5 ) found altered in adenocarcinomas of the breast , colon and lung . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
PURPOSE : To determine genetic alterations at chromosomes 13 and 17 in colorectal tumors , we have studied several loci on these chromosomes , with special focus on the RB 1 and TP 53 genes at both the level of DNA sequence and the level of gene expression . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In addition , certain loci and genes exhibited frequent non random deletion in teratomas ( D3S32 , D3S42 , D5S12 , D10S25 , D11S12 , RB 1 , TP 53 , NME 1 , NME 2 , D17S4 , D18S6 and D20S6 ) and embryonal carcinomas ( IFNB , D9S27 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These included several markers linked to known tumor suppressor genes ( TP 53 , APC , DCC , RB 1 , and BRCA 1 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The retinoblastoma gene RB 1 shows a variety of abnormalities in about 20 % of breast cancers , and there may be an association with TP 53 mutations . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These findings suggest that the inactivation of tumor suppressor genes including Trp 53 , Rb 1 , and an unidentified gene on chromosome 4 plays a significant role during carcinogenesis in mice . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
In osteosarcoma the RB 1 gene is often affected , as is the gene ( TP 53 ) that codes for the p 53 protein . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Cytogenetic losses of 5q21 , 13q14 , and 17p13 ( sites of the APC , RB 1 , and TP 53 suppressor loci , respectively ) also are common in SCLC . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Forty three of the 214 ( 20 % ) tumors exhibited 11q deletions ; 11q deletions were the second most frequent chromosome aberration following 13q14 ( RB 1 and / or D13S25 ) deletions ( 45 % ) ; they were more frequent than trisomy 12 ( 15 % ) or deletion of 17p ( TP 53 gene ) ( 10 % ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The recurrent deletions encompass sites of tumor suppressor genes commonly inactivated in lung carcinomas , such as CDKN 2 ( 9p21 ) , RB 1 ( 13q14 ) , and TP 53 ( 17p13 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
PURPOSE : TP 53 and RB 1 gene mutations in bladder transitional cell carcinoma ( TCC ) are correlated with grade , stage , recurrence , and survival and may correlate with tumor cell apoptotic potential . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Twenty primary central nervous system lymphomas ( PCNSL ) from immunocompetent patients ( nineteen B cell lymphomas and one T cell lymphoma ) were investigated for genetic alterations and / or expression of the genes BCL 2 , CCND 1 , CDK 4 , CDKN1A , CDKN2A , MDM 2 , MYC , RB 1 , REL , and TP 53 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Molecular alterations of the RB 1 , TP 53 , and MDM 2 genes in primary and xenografted human osteosarcomas . ^^^ We report the status of the RB 1 , TP 53 , and MDM 2 genes in human osteosarcomas and cell lines established from surgical specimens and transplanted into athymic naked mice . ^^^ TP 53 mutations appear in adult patients , whereas RB 1 alterations occur mostly in younger patients . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Designs were generated for the RB 1 , TP 53 , MLH 1 and BRCA 1 genes that can be readily implemented in research and clinical laboratories as low cost genetic screening tests . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Several TSGs , such as TP 53 , RB 1 and CDKN2A , encode proteins that are significant to the cell cycle . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Each pair of tumors was analyzed for TP 53 mutation , EGFR amplification , and loss of heterozygosity for tumor suppressor genes ( TP 53 , RB 1 , CDKN2A , PTEN , DMBT 1 ) and tumor suppressor gene regions ( 1p36 , 19q13 , 11p15 , 10p15 ) known to be frequently implicated in glioma tumorigenesis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We examined 19 bladder cancer cell lines derived from 17 patients for alterations in TP 53 , RB 1 , CDKN2A , and ARF . ^^^ Twelve cell lines had a mutation in exons 5 11 of TP 53 and , with only one exception , a concomitant loss of RB 1 protein expression . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We applied the fluorescence in situ hybridization ( FISH ) technique with the TP 53 , RB 1 and 21q22 loci on the patient ' s cells . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The highest frequency of loss , 84 % ( 86 of 102 cases ) , was observed for markers mapping near or within BRCA 1 ; other significant frequencies of LOH were observed for loci mapping near or within CDKN2A / CDKN2B ( 56 % ) , BRCA 2 ( 61 % ) , RB 1 ( 67 % ) , or TP 53 ( 73 % ) . ^^^ These data suggest that LOH of BRCA 1 , or a closely linked locus , precedes the loss of CDKN 2 , TP 53 , and RB 1 , and imply that inactivation of a tumor suppressor gene in this region is an important early step in the development of these tumors . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
MYC , RB 1 , TP 53 , and centromere 8 and 17 copy number in B cell non Hodgkin ' s lymphomas assessed by dual color fluorescence in situ hybridization . ^^^ Dual color interphase FISH was performed to B cell Non Hodgkin ' s lymphomas to detect numerical genetic alterations in c MYC , RB 1 , TP 53 and centromere 8 and 17 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
No complementation between TP 53 or RB 1 and 5 src in astrocytomas of GFAP 5 src transgenic mice . ^^^ During tumor progression TP 53 alterations are among the first genetic changes , while derangement of the p16 / p14ARF / RB 1 system occurs later . ^^^ To probe the pathogenetic significance of TP 53 and RB 1 alterations , we introduced a 5 src transgene driven by glial fibrillary acidic protein ( GFAP ) regulatory elements ( which causes preneoplastic astrocytic lesions and stochastically astrocytomas of varying degrees of malignancy ) into TP53+ / or RB 1+ / mice . ^^^ Hemizygosity for TP 53 or RB 1 did not increase the incidence or shorten the latency of astrocytic tumors in GFAP 5 src mice over a period of up to 76 weeks . ^^^ Conversely , the GFAP 5 src transgene did not influence the development of extraneural tumors related to TP 53 or RB 1 hemizygosity . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Loss of heterozygosity ( LOH ) was investigated at nine loci within or close to tumor suppressor genes ( TP 53 , RB 1 , DCC , NM 23 , WT 1 , D14S267 , P 16 , DPC 4 , PTCH ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Multiple myeloma : monoallelic deletions of the tumor suppressor genes TP 53 and RB 1 in long term follow up . ^^^ Recently , a working model of a stepwise malignant transformation in the molecular pathogenesis of multiple myeloma ( MM ) was proposed , involving the tumor suppressor gene TP 53 and retinoblastoma gene ( RB 1 ) as prominent components of cell cycle control . ^^^ To further define the role of TP 53 and RB 1 in disease progression , we retrospectively analyzed by fluorescence in situ hybridization ( FISH ) cytological material from 16 patients who underwent sequential bone marrow biopsies during the course of their disease . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These data indicate that genes involved in the RB 1 and TP 53 associated cell cycle regulatory pathways may play prominent roles in the development of human MFH . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We performed cytogenetic investigations in 20 splenic and in 10 nodal MZBL and analyzed 52 MZBL ( including 12 MALT type lymphomas ) for deletions of TP 53 , D13S25 , and RB 1 loci by fluorescence in situ hybridization . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We have analyzed the expression of the CDKN1A ( p 21 ( CIP 1 ) ) , CDKN1B ( p 27 ( Kip 1 ) ) , TP 53 , RB 1 and MDM 2 proteins and tumor cell proliferation by immunohistochemical staining in 59 cases of metastatic melanoma . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Apoptosis was evaluated by TUNEL technique ( TdT mediated dUTP nick end labeling ) and the presence of EBV latent membrane protein 1 as well as expression of Bcl 2 , tumor suppressor p 53 , p21WAF1 , MDM 2 , Rb 1 , PCNA , p27KIP1 and caspase 3 , was detected immunocytochemically on paraffin embedded lymph node specimens obtained at diagnosis . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Primary cervical carcinomas show 2 common regions of deletion at 3P , 1 within the FHIT gene : evaluation of allelic imbalance at FHIT , RB 1 and TP 53 in relation to survival . ^^^ Tumors were also analyzed for AI at loci within the RB 1 ( chromosome band 13q14 . 2 ) and the TP 53 ( 17p13 ) genes for AI . ^^^ AI was found in TP 53 and RB 1 in 18 % and 29 % of the samples , respectively . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Minimal regions of overlap for deletions were assigned to 4p14 15 ( PCDH 7 ) , 8p21 22 ( FEZ 1 ) , 9p12 13 , 13q14 31 ( RB 1 ) , 14q31 ( TSHR ) , 16p12 13 . 1 ( GSPT 1 ) , 16q21 23 ( CDH 1 ) , 17p12 13 ( TP 53 ) , and 18q21 22 ( DPC 4 , DCC ) . ^^^ Loss on 17p , including the TP 53 region , appeared significantly more prevalent in HBV associated liver cancers , whereas loss on 13q , with possible involvement of RB 1 , was distinguished as a possible genetic biomarker . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We present a cytogenetic and fluorescence in situ hybridization ( FISH ) study , using centromeric probes for chromosomes 3 , 7 , 11 , and 18 , TP 53 gene ( 17p13 ) , and RB 1 locus ( 13q14 ) DNA probes , in four cases of plasma cell leukemia ( PCL ) . ^^^ Among the four cases , three presented monosomy of the RB 1 locus and one monoallelic deletion of the TP 53 gene . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Cell growth regulators include proteins of the p 53 pathway encoded by the genes CDKN2A ( p 16 , p14arf ) , MDM 2 , TP 53 , and CDKN1A ( p 21 ) as well as proteins encoded by genes like RB 1 , E2F , and MYCL . ^^^ We found a significant difference in the numbers of gene loci hit by deletions muscle invasive versus noninvasive tumors ( P = 0 . 0000002 ) , with the genes most often hit by deletions in muscle invasive tumors being TP 53 , RB 1 , and MYCL . ^^^ A more pronounced deletion of TP 53 ( P = 0 . 002 ) and RB 1 ( P = 0 . 02 ) was found in the progressing tumor group compared with the recurrent noninvasive group , and , finally , the combined loss of TP 53 and RB 1 was present only in the progressing tumor or muscle invasive groups . ^^^ Deletion of two or more loci in TP 53 , MYCL , RB 1 , and CDKN2A was found in 10 patients in the progressing tumor group and in only 1 patient in the recurrent noninvasive group ( P = 0 . 004 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
C cell hyperplasia foci were microdissected for DNA extraction to analyze the methylation pattern of androgen receptor alleles and microsatellite regions ( TP 53 , RB 1 , WT 1 , and NF 1 ) . ^^^ C cell hyperplasia foci showed heterogeneous DNA deletions revealed by loss of heterozygosity of TP 53 ( 12 of 20 ) , RB 1 ( 6 of 14 ) , and WT 1 ( 4 of 20 ) and hypodiploid G0 / G1 cells ( 14 of 20 ) , low cellular turnover ( MIB 1 index 4 . 5 % , in situ end labeling index 0 . 03 % ) , and significantly high nuclear area to DNA index ratio . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Concurrent inactivation of RB 1 and TP 53 pathways in anaplastic oligodendrogliomas . ^^^ Of 13 anaplastic astrocytomas with an altered RB 1 pathway , 9 ( 69 % ) also showed a dysregulated TP 53 pathway . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Molecular genetic abnormalities preceding , or occurring during , BC include overexpression of the BCR / ABL transcript , upregulation of the EVI 1 gene , increased telomerase activity , and mutations of the tumor suppressor genes RB 1 , TP 53 , and CDKN2A . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
To elucidate the biochemical processes involved in the pathogenesis of B CLL and MCL , we analyzed the expression level of a set of genes that play central roles in apoptotic or cell proliferation pathways and of candidate genes from frequently altered genomic regions , namely ATM , BAX , BCL 2 , CCND 1 , CCND 3 , CDK 2 , CDK 4 , CDKN1A , CDKN1B , E2F1 , ETV 5 , MYC , RB 1 , SELL , TFDP 2 , TNFSF 10 , and TP 53 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
To date , molecular genetic studies of CML BC have mainly focused on alterations of well known tumor suppressor genes ( e . g . , TP 53 , CDKN2A , and RB 1 ) and oncogenes ( e . g . , RAS and MYC ) , whereas limited knowledge is available about the molecular genetic correlates of the unbalanced chromosomal abnormalities . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These loci were three cancer implicated genes ( TP 53 , AML 1 , and RB 1 ) and two nontranscribed sequences engaged in chromosome segregation . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
To determine the frequency and timing of hypermethylation during carcinogenesis of astrocytic tumors , we analysed promoter methylation status of ten tumor associated genes ( MGMT , GSTP 1 , DAPK , p14ARF , THBS 1 , TIMP 3 , p 73 , p16INK4A , RB 1 and TP 53 ) in a series of 88 astrocytic gliomas , including 24 diffuse astrocytomas ; 21 anaplastic astrocytomas , and 43 glioblastomas ( 33 primary and 10 secondary ) , as well as two non neoplastic brain samples , by methylation specific PCR . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We have determined the promoter CpG island methylation status of O ( 6 ) methylguanine DNA methyltransferase ( MGMT ) , glutathione S transferase P 1 ( GSTP 1 ) , death associated protein kinase ( DAPK ) , p 14 ( ARF ) , thrombospondin 1 ( THBS 1 ) , tissue inhibitor of metalloproteinase 3 gene ( TIMP 3 ) , p 73 , p 16 ( INK4A ) , RB 1 , and TP 53 genes in three primary central nervous system lymphomas ( PCNSL ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We revealed a certain heterogeneity in the copy number of the Rb 1 , N myc , and TP 53 gene loci in tumour cells . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We determined the frequency of aberrant CpG island methylation of several tumour associated genes : MGMT , GSTP 1 , DAPK , p14ARF , THBS 1 , TIMP 3 , p 73 , p16INK4A , RB 1 and TP 53 in 24 neurogenic tumours consisting of pilocytic astrocytomas ( n=13 ) and medulloblastomas ( n=11 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
PURPOSE : To analyze the genetic and epigenetic alterations affecting the RB 1 , TP 53 , p16INK4 , and p21WAF1 tumor suppressor genes , loss of heterozygosity ( LOH ) at 3q and 18q , and the clinical variables of a series of Spanish children with osteosarcoma . ^^^ The mutation and methylation status of p16INK4 , p21WAF1 , TP 53 , and RB 1 was screened as well as LOH at 3q and 18q . ^^^ RESULTS : Loss of heterozygosity affecting RB 1 ( 37 . 2 % ) , TP 53 ( 42 . 3 % ) , and 18q ( 30 . 8 % ) and TP 53 mutation ( 39 % ) were frequently encountered . ^^^ CONCLUSIONS : RB 1 , TP 53 , and possibly other tumor suppressor genes located at 18q and other localizations are involved in pediatric osteosarcoma carcinogenesis , together with other genetic alterations not fully understood to date . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The frequencies of aberrant methylation were : 64 % for thrombospondin 1 ( THBS 1 ) ; 30 % for tissue inhibitor of metalloproteinase 3 ( TIMP 3 ) ; 27 % for O 6 methylguanine DNA methyltransferase ( MGMT ) ; 25 % for p 73 ; 18 % for RB 1 ; 14 % for death associated protein kinase ( DAPK ) , p14ARF , p16INK4a and caspase 8 , and 0 % for TP 53 and glutathione S transferase P 1 ( GSTP 1 ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The frequencies of hypermethylation for the 10 genes were as follows , in oligodendrogliomas and ependymomas , respectively : 80 % and 28 % for MGMT ; 70 % and 28 % for GSTP 1 ; 66 % and 57 % for DAPK ; 44 % and 28 % for TP 14 ( ARF ) ; 39 % and 0 % for THBS 1 ; 24 % and 28 % for TIMP 3 ; 24 % and 14 % for TP 73 ; 22 % and 0 % for TP 16 ( INK4A ) ; 3 % and 14 % for RB 1 ; and 0 % in both neoplasms for TP 53 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
For FISH the following probes were used : MLL , CBF beta / MYH11 , ETV 6 / AML1 ; AML1 / ETO , BCR / ABL , PML / RAR , c MYC , TP 53 , RB 1 , 5q31 / 5p15 . 2 , 5q33 34 , 7q31 / CEP7 , 20q13 ; CEP 4 , 10 , Y . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We have determined the methylation status of the CpG island of 11 tumour related genes ( RB 1 , p14ARF , p16INK4a , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 , caspase 8 , TP 53 and GSTP 1 ) in 18 neurofibromas ( including one plexiform neurofibroma ) and three neurofibrosarcomas , as well as two non neoplastic peripheral nerve sheath samples , using methylation specific polymerase chain reaction . ^^^ The incidence of aberrant methylation in the tumour samples was 52 % for THBS 1 , 43 % for MGMT , 33 % for TIMP 3 , 19 % each for p16INK4a and p 73 , 14 % for RB 1 , 5 % for p14ARF , and 0 % for DAPK , caspase 8 , TP 53 and GSTP 1 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Analysis of the involvement of the tumour suppressor genes TP 53 , p16INK4 , p21WAF1 , RB 1 and the drugs metabolizing enzymes in the development of bone tumours in children ] . ^^^ BACKGROUND : Several tumor suppressor genes such as p16INK4 , TP 53 , RB 1 y p21WAF1 are involved in cell cycle regulation in response to DNA damage and belong to the complex pathway that regulates cell proliferation and / or differentiation . ^^^ MATERIALS AND METHODS : By means of PCR based techniques , we have analyzed the presence of variations in the coding sequence of p16INK4 , TP 53 , RB 1 y p21WAF1 and of the Drug Metabolizing Enzymes in a group of 82 osteosarcomas and 47 Ewing ' s sarcomas as well as in a control group of 115 healthy children . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We examined the DNA methylation status of 12 tumor related genes ( NF 2 , RB 1 , p 14 ( ARF ) , p 16 ( INK4a ) , p 73 , TIMP 3 , MGMT , DAPK , THBS 1 , caspase 8 , TP 53 , and GSTP 1 ) in 44 sporadic and / or NF 2 associated schwannomas using methylation specific PCR . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We detected methylation levels in the tumor samples of 83 % in p16INK4a , 72 % in DAP kinase , 56 % in THBS 1 , 50 % in RB 1 , 39 % in MGMT , 33 % in GSTP 1 and p14ARF each , 22 % in p 73 and TIMP 3 each , and 11 % in TP 53 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The past 15 years has seen the establishment of mouse lines heterozygous or homozygous null for genes known or suspected of being involved in human cancer syndromes , including APC , ATM , BLM , BRCA 1 , BRCA 2 , LKB 1 , MEN 1 , MLH , MSH , NF 1 , TP 53 , PTEN , RB 1 , TSC 1 , TSC 2 , VHL , and XPA . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
By using tumor suppressor genes TP 53 , PTEN and RB 1 , we identify seven genes that also include hepsin , GSTP 1 and AMACR . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
CDKN2A , 9p21 , encodes two alternatively spiked , functionally distinct , tumor suppressor proteins , P16INK4A and P14ARF , which play active roles in the RB 1 and TP 53 pathways , respectively . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
METHODS : For this purpose , we performed a comparative analysis of the frequency of deletions of BRCA 1 , BRCA 2 , BRCAX , TP 53 , ATM , and RB 1 and amplification of Cyclin D 1 and also studied the interrelation and prognostic significance of these genetic alterations in 30 early onset ( < or =40 years ) and 33 late onset ( > 40 years ) cases of BC . ^^^ RESULTS : A differential pattern of alterations ( deletion / amplification ) was observed in the two age groups , with the sequence in younger women being BRCA 1 ( 72 % ) , TP 53 ( 71 % ) , ATM ( 64 % ) , BRCA 2 ( 62 % ) , RB 1 ( 60 % ) , Cyclin D 1 ( 43 % ) , and BRCAX ( 24 % ) and that in the older group being TP 53 ( 66 % ) , RB 1 ( 63 % ) , BRCA 1 ( 56 % ) , ATM ( 53 % ) , BRCA 2 ( 45 % ) , Cyclin D 1 ( 24 % ) , and BRCAX ( 23 % ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These included 3 genes coding for proteins in the p 53 pathway ( i . e . , TP 53 , p 14 ( ARF ) , and MDM 2 ) , 4 in the Rb 1 pathway ( i . e . , CDKN2A , CDKN2B , RB 1 , and CDK 4 ) , as well as PTEN and epidermal growth factor receptor . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Induction of small cell lung cancer by somatic inactivation of both Trp 53 and Rb 1 in a conditional mouse model . ^^^ We established a mouse model for neuroendocrine ( NE ) lung tumors by conditional inactivation of Rb 1 and Trp 53 in mouse lung epithelial cells . ^^^ Mice carrying conditional alleles for both Rb 1 and Trp 53 developed with high incidence aggressive lung tumors with striking morphologic and immunophenotypic similarities to SCLC . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
PURPOSE : The chromosome 9p21 region harbors three tumor suppressor genes , p 14 ( ARF ) , p 15 ( INK4b ) , and p 16 ( INK4a ) , all of which can be targets for hypermethylation associated inactivation in low grade gliomas . p 16 ( INK4a ) and p 15 ( INK4b ) are critically involved in the RB 1 pathway , whereas p 14 ( ARF ) acts as an upstream regulator of the TP 53 pathway . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Crossing Bub 3 ( + / ) mice onto a heterozygous tumor suppressor background of Trp 53 or Rb 1 similarly revealed no substantial differences in either the number or the rate at which tumors appeared . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
These included three genes coding for proteins in the p 53 pathway ( TP 53 , p 14 ( ARF ) and MDM 2 ) , four in the Rb 1 pathway ( CDKN2A , CDKN2B , RB 1 and CDK 4 ) and PTEN and EGFR . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We analyzed the loss of heterozygosity ( LOH ) and the presence of mutations for a series of genes implicated in DSB repair by non homologous end joining in five radiation induced sarcomas devoid of both active Tp 53 and Rb 1 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We determined the mRNA expression of p 1 ( INK4A ) , p 14 ( ARF ) , CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 by quantitative reverse transcription PCR in 38 cases of GISTs and correlated the findings with clinicopathologic factors , including mutation analysis of KIT and PDGFRA . ^^^ GISTs with low mRNA expression of the CDKN2A transcripts p 16 ( INK4A ) and p 14 ( ARF ) but high mRNA expression of CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 were associated with aggressive clinical behavior and unfavorable prognosis , whereas GISTs with a low mRNA expression of CDK 4 , RB 1 , MDM 2 , TP 53 , and E2F1 were not . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
None of the tumors simultaneously showed LOH at TP 53 and RB 1 genes ( R= 0 . 211 , p=0 . 16 ; Spearman ' s rank correlation test ) . p16INK4A alterations ( LOH and gene deletion ) occurred concomitantly , with 3 tumors showing the TP 53 allelic loss , whereas the cyclin D1 / cdk4 complex was overexpressed in a case with TP 53 LOH . ^^^ Allelic loss at TP 53 seems to arise independently of LOH at the RB 1 gene in carcinomas of the uterine corpus in humans . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Furthermore , increased protein levels of PPM1D and CDK 6 may link the TP 53 and RB 1 tumor suppressor pathways to medulloblastoma pathomechanisms . . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Some markers were intragenic for BRCA 1 , BRCA 2 , BRCAX , ATM , TP 53 , and RB 1 . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Genes that were frequently deleted included ( 56 . 7 % ) , FGFR 2 ( 66 . 7 % ) , MTAP ( 60 . 0 % ) , DMBT 1 CDKN2A ( p 16 ) / MTAP ( 50 . 0 % ) , PIK3CA ( 43 . 3 % ) , and EGR 2 ( 43 . 3 % ) , but deletion of RB 1 or TP 53 was rarely detected . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
METHODS : We employed reverse transcription and real time fluorescent PCR to quantify the expression of nine genes ( BRCA 1 , BRCA 2 , ATM , TP 53 , RB 1 , MAD 2 , BUB 1 , APC and beta actin ) in oocytes and embryos . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Five polymorphic DNA regions from TP 53 , RB 1 , WT 1 , and NF 1 were systematically studied by PCR denaturing gradient gel electrophoresis . ^^^ RESULTS : Loss of heterozygosity / single nucleotide polymorphism involved TP 53 in 40 of 134 informative cases ( 29 . 9 % ) , RB 1 in 22 of 106 informative cases ( 20 . 8 % ) , WT 1 in 32 of 120 informative cases ( 26 . 7 % ) , and NF 1 in 32 of 80 informative cases ( 40 . 0 % ) . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
Analysis of mRNA and protein levels in melanomas with 12q14 amplification demonstrated overexpression of target genes CDK 4 and MDM 2 without loss of CDKN2A P 16 ( P16INK4A ) or CDKN2A P14ARF ( P14ARF ) expression , important regulators of the RB 1 and TP 53 pathways , which are commonly lost or mutated in melanoma . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
The second set of genetic alterations are etiological nonspecific , it includes recurrent gains and losses of chromosomes , alteration of TP 53 gene , activation of WNT / beta catenin pathway through CTNNB1 / beta catenin and AXIN ( axis inhibition protein ) mutations , inactivation of retinoblastoma and IGF2R ( insulin like growth factor 2 receptor ) pathways through inactivation of RB 1 ( retinoblastoma 1 ) , P 16 and IGF2R . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
We have previously described a mouse model of SCLC by somatic conditional disruption of Trp 53 and Rb 1 genes that closely resembles the human condition . ^^^
Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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Interacting proteins: P06400 and P04637	Pubmed	SVM Score :0.0
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