| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| On redistribution of endogenous lamin A / C and LAP2alpha into nuclear aggregates by overexpressing dominant negative lamin mutants in tissue culture cells , Rb was also sequestered into these aggregates . ^^^ Together , these data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha lamin A / C complexes . . ^^^ |
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| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we identified seven proteins co immunoprecipitating with Rb in this tumor , including Lamin A / C and six proteins not previously reported to bind Rb : Hsc 70 , high mobility group protein 1 ( HMG 1 ) , hnRPN , glyceraldehyde 3 phosphate dehydrogenase ( G3PDH ) , EF 1 , and EF 2 . ^^^ |
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| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| The present study was designed to assess the clinicopathological significance of RB and p 53 pathway related proteins ( p 53 , p21WAF1 / CIP1 and Bax ) expression in resectable invasive ductal carcinoma ( IDC ) of the pancreas . ^^^ However , coexpression analysis of RB and p 53 pathway related proteins indicated that , in the patients with RB ( + ) IDC , the p21WAF1 / CIP1 ( + ) group had a significantly higher survival rate than the p21WAF1 / CIP1 ( ) group . ^^^ On the other hand , in the patients with RB ( ) IDC , the Bax ( + ) group had a significantly higher survival rate than the Bax ( ) group . ^^^ |
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| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| Lmna ( / ) cells resemble Rb ( / ) cells , exhibiting altered cell cycle properties and reduced capacity to undergo cell cycle arrest in response to DNA damage . ^^^ |
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| Interacting proteins: P02545 and P06400 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , Lmna null muscle did not show the same perturbations to Rb and MyoD dependent pathways . ^^^ We did observe increased transcriptional expression of Lap2alpha and delayed expression of Rb 1 , which may regulate alternative transcriptional pathways in the Lmna null myoblasts . ^^^ We suggest that the dominant LMNA mutations seen in many clinically disparate laminopathies may similarly alter Rb function , with regard to either the timing of exit from the cell cycle or terminal differentiation programs or both . . ^^^ |
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