| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.68053971 |
| We show that HBP 1 can interact with one of these , RB , both in vitro and in mammalian cells . 0.68053971^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| We have isolated the HBP 1 transcriptional repressor as a potential target of the RB family in differentiated cells . ^^^ First , inspection of the HBP 1 protein sequence revealed two consensus RB interaction motifs ( LXCXE and IXCXE ) . ^^^ Second , HBP 1 interaction was selective for RB and p 130 , but not p 107 . ^^^ HBP 1 , RB , and p 130 levels are all up regulated with differentiation ; in contrast , p 107 levels decline . ^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| The RB family and targets such as E2F and HBP 1 have functions in each step . ^^^ RB . p 130 , HBP 1 , and other proteins appear to have unexpected functions in regulating tissue specific gene expression . ^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| To probe the functions of the retinoblastoma protein ( RB ) family in cell differentiation , we isolated HBP 1 as a specific target of RB and p 130 . ^^^ The induction of HBP 1 , RB , and p 130 upon differentiation in the muscle C2C12 cells suggested a coordinated role . ^^^ The inhibition of MyoD family function by HBP 1 required binding to RB and / or p 130 . ^^^ Further investigation implicated the relative ratio of RB to HBP 1 as a determinant of whether cell cycle exit or full differentiation occurred . ^^^ Thus , we postulate that the relative ratio of RB to HBP 1 may be one signal for activation of the MyoD family . ^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| Interestingly , our cloning strategy led to the isolation of a retinoblastoma protein ( RB ) partner known as HBP 1 . ^^^ Finally , we demonstrated that both HBP 1 and RB were involved in the activation of H 1 ( 0 ) gene expression . ^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| We previously isolated HBP 1 as a target of the retinoblastoma ( RB ) and p 130 family members and as the first of the HMG box transcriptional repressors . ^^^ Finally , transgenic mice expressing a mutant HBP 1 lacking the N terminal RB interacting domain showed a stronger S phase response following partial hepatectomy . ^^^ |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O60381 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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