| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.57348867 |
| Rb associates with SUV39H1 and HP 1 in vivo by means of its pocket domain . 0.57348867^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| Interestingly , phosphorylation of Rb in vitro as well as in vivo abolished the Rb Suv39H1 interaction . ^^^ We also found that Suv39H1 and Rb cooperate to repress E2F activity and that Suv39H1 could be recruited to E2F1 through its interaction with Rb . ^^^ Taken together , these data indicate that Suv39H1 is involved in transcriptional repression by Rb and suggest an unexpected link between E2F regulation and heterochromatin . . ^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| Consistent with this interpretation , the N terminal transcriptional repression domain of Suv39H1 bound the so called ' core histone deacetylase complex ' , composed of HDAC 1 , HDAC 2 and the Rb associated proteins RbAp 48 and RbAp 46 . ^^^ Taken together , our results suggest that a complex containing both the Suv39H1 histone methyl transferase and histone deacetylases could be involved in heterochromatin silencing or transcriptional repression by Rb . . ^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| We found that these two pocket proteins share with Rb the ability to associate with the histone methyl transferase SUV39H1 . ^^^ |
|
| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| Here we show that p 130 is the predominant Rb family member associated with E2F in neurons , that its major partner for repression of pro apoptotic genes is E2F4 , and that the p 130 E2F4 complex recruits the chromatin modifiers HDAC 1 and Suv39H1 to promote gene silencing and neuron survival . ^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| Recently , Rb mediated silencing of growth promoting genes by heterochromatin formation associated with methylation of histone H 3 lysine 9 ( H3K9me ) was identified as a critical feature of cellular senescence , which may depend on the histone methyltransferase Suv39h1 . ^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| RB recruits a number of proteins , including HDACs , SWI / SNF complex , lysine methyl transferase ( SUV39H1 ) and DNA methyltransferase ( DNMT 1 ) , all of which negatively regulate E2F activity with RB . ^^^ |
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| Interacting proteins: O43463 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
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