Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
While the three cloned species of E2F , E2F 1 , E2F 2 , and E2F 3 , are known to be targets of RB interaction , no E2F species has yet been shown to be a specific p 107 or p 130 target . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
In contrast to full length E2F 3 , which is expressed only at the G1 / S boundary , E2F 3B is detected throughout the cell cycle with peak levels in GO where it is associated with Rb . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Using such analysis , E2f 1 , E2f 3 , p 53 , and Id 2 have been identified as important regulators of cell cycle control and apoptosis in Rb ( / ) embryos . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
The CHR mutated promoter is activated by the E2F family of proteins ( E2F1 , E2F2 , E2F3 , and E2F4 ) but unable to be repressed by any of the Rb family members ( Rb , p 107 , and p 130 ) to the level of the wild type promoter activity in G 0 , indicating that the repression by the Rb family members is required for the corepressor element . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Furthermore , Rb / cells surviving in vitro exhibit an upregulation of p 107 that is found in complexes with E2F3 . ^^^ While p 107 is upregulated and interacts with the putative Rb target E2F3 in neural precursor cells , our results indicate that it clearly can not restore normal E2F regulation . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos . ^^^ Here we show that the E2f3 mutation completely suppresses both the inappropriate proliferation and the p 53 dependent apoptosis arising in the Rb mutant embryos . ^^^ Through the analysis of Rb ( / ) ; E2f3 ( + / ) embryos , we have been able to separate E2F3 ' s role in the induction of apoptosis from its ability to induce proliferation . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Specificity of E2F1 , E2F2 , and E2F3 in mediating phenotypes induced by loss of Rb . ^^^ Here , we report that E2F1 , E2F2 , and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency . ^^^ In the developing lens of Rb ( / ) embryos , loss of E2F1 , E2F2 , or E2F3 reduces the unscheduled proliferation of fiber cells , with the loss of E2F3 having the most pronounced effect . ^^^ In the central nervous system , loss of E2F1 or E2F3 can almost completely eliminate the ectopic DNA replication and apoptosis observed in Rb ( / ) embryos , and loss of E2F2 partially reduces the unscheduled DNA replication and has no effect on apoptosis . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Silibinin treatment of cells resulted in a strong increase ( up to 2 . 3 and 5 . 4 fold ) in the levels of hypophosphorylated Rb / p107 and Rb2 / p130 , respectively , but a strong decrease ( 91 , 78 and 45 % ) in protein levels of transcription factors E2F3 , E2F4 and E2F5 , respectively . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Silibinin treatments also resulted in an increase in the amount of Rb binding to E2F1 ( 3 . 8 fold ) , E2F2 ( 2 . 2 fold ) , and E2F3 ( 2 . 2 fold ) . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
Here we show that E2F3 also has a significant effect on the phenotype of tumor prone Rb ( + / ) mice . ^^^ E2F3 loss suppresses the development of the pituitary tumors that normally account for the death of Rb ( + / ) mice . ^^^ Finally , analysis of Rb ( + / ) ; E2f3 ( + / ) mice shows that this tumor suppressive function of E2F3 is dose dependent . . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
We have mutated Rb 1 in the mouse to express a protein ( R654W ) specifically deficient in binding E2F1 , E2F2 , and E2F3 . ^^^ R654W mutant embryos exhibit cell cycle defects the same as those of Rb 1 null embryos , reinforcing the importance of the interactions of pRb with E2F1 , E2F2 , and E2F3 for cell cycle control . ^^^ These data indicate that Rb 1 makes important cell type specific contributions to cellular differentiation that are genetically separable from its general ability to stably bind E2F1 , E2F2 , and E2F3 and regulate the cell cycle . . ^^^
Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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Interacting proteins: O00716 and P06400	Pubmed	SVM Score :0.0
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