| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| Cholecystokinin ( CCK ) levels are greatly reduced in the brains but not the duodenums of Cpe ( fat ) / Cpe ( fat ) mice : a regional difference in the involvement of carboxypeptidase E ( Cpe ) in pro CCK processing . ^^^ In order to assess the possible role of carboxypeptidase E ( Cpe ) in pro CCK processing , tissues from the Cpe ( fat ) / Cpe ( fat ) mice were analyzed for CCK content and molecular forms using specific RIAs directed against different portions of the prohormone . ^^^ Levels of amidated CCK were decreased by about 74 % in whole brain of Cpe ( fat ) / Cpe ( fat ) mice in comparison to control mice , while levels of amidated CCK in intestine were only reduced by about 36 % . ^^^ In contrast , using an antiserum specific for CCK Gly Arg Arg , Cpe ( fat ) / Cpe ( fat ) mice brain had about 13 fold higher levels of this peptide relative to controls , while levels were identical in mutant and control duodenal tissue . ^^^ This study demonstrates a regional difference in the involvement of Cpe in pro CCK processing . ^^^ |
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| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| In the brain , bioactive CCK was markedly reduced ( 7 . 9+ / 1 . 0 pmol / g in fat / fat mice vs . 82 . 5+ / 11 . 2 pmol / g in controls ) , but the concentration of the CPE substrate , glycylarginine extended CCK , was elevated 105 fold . ^^^ These results demonstrate that the CPE mutation differentially affects CCK processing in these two cell types . ^^^ |
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| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| Adult carboxypeptidase E deficient fat / fat mice have a near total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK : identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain . ^^^ Cholecystokinin ( CCK ) amide concentrations were reduced over 85 % in all the major brain regions of carboxypeptidase E ( Cpe ) ( fat ) / Cpe ( fat ) mice in comparison to control mice . ^^^ Using an radioimmunoassay ( RIA ) specific for glycine extended CCK ( CCK Gly ) , low levels of CCK Gly were detected in control ( 0 . 65 ng / g tissue ) and were even lower in Cpe ( fat ) / Cpe ( fat ) ( 0 . 246 ng / g ) mice brain extracts . ^^^ After treatment with carboxypeptidase B , the level of CCK Gly in Cpe ( fat ) / Cpe ( fat ) in these brain extracts was elevated to 33 . 5 ng / g , about 51 fold higher than in control . ^^^ These results demonstrate that CPE is required for the correct processing of arginine and glycine extended CCK in all major regions of the mouse brain . ^^^ |
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| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06307 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|