| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :1.0269238 |
| Molecular interaction between the Fyn associated protein SKAP 55 and the SLP 76 associated phosphoprotein SLAP 130 . 1.0269238^^^ |
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| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :1.0383936 |
| Two dimensional gel electrophoresis of anti p59fyn immunoprecipitates obtained from non transformed resting human T lymphocytes resulted in the identification of an oligomeric protein complex which is constitutively formed between Fyn and several additional phosphoproteins ( pp 43 , pp 72 , pp 85 , the protein tyrosine kinase Pyk 2 , as well as the two recently cloned adaptor proteins , SKAP 55 and SLAP 130 ) . 1.0383936^^^ Among the individual members of the Fyn complex pp 85 , SKAP 55 and pp 43 are constitutively phosphorylated on tyrosine residue ( s ) in vivo and likely interact with Fyn via its src homology 2 ( SH 2 ) domain . 0.74510831^^^ |
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| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.87086644 |
| SKAP 55 as a substrate interacted with Fyn kinase in vivo . 0.87086644^^^ Intriguingly , T cell receptor engagement dramatically induced the translocation of endogenous SKAP 55 to lipid rafts where SKAP 55 was found to interact with Fyn kinase , suggesting that the positive function of SKAP 55 via its association with Fyn and other signaling components may have been involved in raft mediated T cell activation . . 0.63214616^^^ |
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| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| In human T lymphocytes the Src family protein tyrosine kinase p 59 ( fyn ) associates with three phosphoproteins of 43 , 55 , and 85 kDa ( pp 43 , pp 55 , and pp 85 ) . ^^^ Employing a GST Fyn Src homology 2 ( SH 2 ) domain fusion protein pp 55 was purified from lysates of Jurkat T cells . ^^^ Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ SKAP 55 is detected in resting human T lymphocytes as a constitutively tyrosine phosphorylated protein that selectively interacts with p 59 ( fyn ) . ^^^ These data suggest that SKAP 55 represents a novel adaptor protein likely involved in Fyn mediated signaling in human T lymphocytes . . ^^^ |
|
| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| Molecular analysis of the fyn complex : cloning of SKAP 55 and SLAP 130 , two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor mediated signaling . ^^^ |
|
| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| FYB ( FYN binding protein ) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP 55 and a SKAP 55 related protein in T cells . ^^^ Both SKAP 55 and SKAP55R were found to bind FYB through their SH 3 domains and to act as substrates for the FYN kinase in T cells . ^^^ |
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| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| RA 70 as well as SKAP 55 proved to be a protein with molecular weight 55 kDa associated with SH 2 domain of Fyn . ^^^ |
|
| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , overexpression of SKAP 55 Y232F also caused the tyrosine hyperphosphorylation of Fyn with a decreased kinase activity . ^^^ |
|
| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , MIST was preferentially recruited to Fyn rather than Lyn , which is regulated by higher affinity binding of SLAP 130 and SKAP 55 with the Fyn SH 2 domain than the Lyn SH 2 domain . ^^^ |
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| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86WV1 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|