| Interacting proteins: Q14643 and P06241 |
Pubmed |
SVM Score :0.0 |
| T cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP3R , which induced tyrosine phosphorylation of the IP3R . ^^^ Fyn activated an IP 3 gated calcium channel in vitro , and tyrosine phosphorylation of the IP3R during T cell activation was reduced in thymocytes from fyn / mice . ^^^ |
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| Interacting proteins: Q14643 and P06241 |
Pubmed |
SVM Score :0.0 |
| Engagement of the T cell or B cell receptor by antigen initiates a signal transduction cascade that leads to tyrosine phosphorylation of IP3R by Src family nonreceptor protein tyrosine kinases , including Fyn . ^^^ We have identified tyrosine 353 ( Tyr 353 ) in the IP 3 binding domain of type 1 IP3R ( IP3R1 ) as a phosphorylation site for Fyn both in vitro and in vivo . ^^^ |
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| Interacting proteins: Q14643 and P06241 |
Pubmed |
SVM Score :0.0 |
| IP3R1 function is regulated by at least two major cellular signaling pathways : the second messenger IP 3 activates the channel , and phosphorylation by nonreceptor protein tyrosine kinases ( e . g . , Fyn ) increase its open probability . ^^^ |
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