| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.51975263 |
| Two dimensional gel electrophoresis of anti p59fyn immunoprecipitates obtained from non transformed resting human T lymphocytes resulted in the identification of an oligomeric protein complex which is constitutively formed between Fyn and several additional phosphoproteins ( pp 43 , pp 72 , pp 85 , the protein tyrosine kinase Pyk 2 , as well as the two recently cloned adaptor proteins , SKAP 55 and SLAP 130 ) . 0.51975263^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| PRAP was found to function as a substrate for Src family kinases , such as c Src or Fyn , but not for Pyk2 / RAFTK . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| One IL 2 regulated PTK implicated in this cascade is the Src family kinase , Fyn . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| To date , Fyn is the first PTK demonstrated to be present in the mammalian egg . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , another Src family PTK , Fyn , was not affected by A6H ligation . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Interestingly , both Pyk 2 and FPhy 2 ( to a greater extent ) were tyrosine phosphorylated and associated with Src and Fyn . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast to Lyn , PYK 2 , FAK , MAPK / ERK1 , SAPK / JNK , and Cdk 5 , only Fyn could phosphorylate alpha synuclein . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Greater than 85 90 % of Src and Fyn were present in lipid rafts , whereas Pyk 2 was mainly associated with PSDs . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| PKC depletion did not alter Ang 2 dependent tyrosine phosphorylation or activity of p 125 ( FAK ) , CADTK , Fyn or Src , but PKC depletion or incubation with GF109203X resulted in Ang 2 dependent EGF receptor tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Whereas PSD associated proline rich tyrosine kinase 2 ( PYK 2 ) and gp145TrkB were elevated immediately after the ischemic event , increases in Src and Fyn were not apparent until 6 hours of reperfusion . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Besides coupling with heterotrimeric G proteins to activate phospholipase C beta ( PLC beta ) , AT1R also activates receptor tyrosine kinases ( PDGF R , EGF R and IGF R ) and non receptor tyrosine kinases ( Src , Fyn , Yes , proline rich tyrosine kinase 2 ( Pyk 2 ) , focal adhesion kinase ( FAK ) and JAK 2 ) . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Analysis of tyrosine phosphorylated RAFTK from adherent transfected COS cells showed that the Src homology 2 ( SH 2 ) domains of the Src and Fyn protein kinases as well as the Grb 2 adaptor protein were able to specifically associate with RAFTK . ^^^ These data suggest that RAFTK is a novel member of the FAK family , that it localizes to focal adhesion like structures in CMK megakaryocytic cells , that it participates in integrinmediated signaling pathways in megakaryocytes , and that it is able to associate with the tyrosine kinases Src and Fyn as well as the adaptor protein Grb 2 via SH 2 phosphotyrosine interactions . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Hic 5 at tyrosine 60 by CAKbeta and Fyn . ^^^ Here we show that overexpression of CAKbeta or Fyn , but not FAK , enhanced the tyrosine phosphorylation of coexpressed Hic 5 in COS 7 cells . ^^^ Specific phosphorylation of Hic 5 by CAKbeta and Fyn may activate a signaling pathway mediated by Hic 5 . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Nonreceptor PTK encoded by mammalian proto oncogenes ( c src , fyn , c yes , c abl ) and their homologs in Drosophila exhibit patterns of expression and activities that suggest functions in axonal or dendritic outgrowth . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Our results show that addition of antibodies to IgD or to IgM can stimulate the PTK activity of the blk , fyn , and lyn gene products . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study we use digitonin to solubilize a murine T cell hybridoma and demonstrate that antibodies binding extracellular but not intracellular domains of the TCR specifically coprecipitate only the fyn PTK and not lck or yes , two other kinases found in these cells . ^^^ The association of the fyn PTK with the TCR might enable the T cell to independently regulate two PTKs through surface receptors . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study , a 10 fold elevated activity of PTK encoded by fyn , another src family gene , was demonstrated in CD 4 CD8 T cells in mutant mice . ^^^ The increased PTK activity was consistent with overexpression of fyn mRNA . ^^^ The fact that fyn mRNA expression was markedly induced in normal T cells by mitogenic stimulation with anti T 3 epsilon antiserum supports the possibility that p59fyn PTK is a signal generating molecule in T cells . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The BCR associates with two classes of tyrosine kinase : Src family kinase ( Src protein tyrosine kinase [ PTK ] ; Lyn , Fyn , Blk , or Lck ) and Syk kinase . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Activation of lymphocytes through the T cell receptor ( TCR ) in collaboration with cell surface accessory molecules results in rapid increases in tyrosine phosphorylation , probably through the recruitment and activation of src family protein tyrosine kinases ( PTK ) such as lck and fyn which have been implicated in mediating the proximal signalling events mediated through the TCR . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The c src gene family has nine known members ( blk , c fgr , fyn , hck , lck , lyn , c src , c yes and yrk ) , each encoding a cytoplasmic protein tyrosine kinase ( PTK ) believed to be involved in signal transduction . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Since N myristoylation of Fyn PTK , a member of the Src family , has been shown to be a prerequisite for palmitolylation , a new single plasmid vector that allows overexpression of myristoylated Fyn substrate in Escherichia coli was developed . ^^^ It is likely that palmitoylation of Fyn and other Src family members by PAT regulates PTK localization and signaling functions . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Beside the protein tyrosine kinase ( PTK ) fyn , protein kinase C ( PKC ) was found to be co isolated with Fc gamma RIIb 1 , suggesting a tight connection between these kinases and Fc gamma RII . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that LFA 1 is physically associated in the YT human NK like cell line cells with a PTK ( s ) that is distinct from Src family PTKs such as Lck , Fyn , or Lyn . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The effect of GM CSF and M CSF on the activation of fyn kinase , a 59 kDa src family related protein tyrosine kinase ( PTK ) , was studied . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The 59 kDa coprecipitated component is identified as the protein tyrosine kinase ( PTK ) fyn . ^^^ Whereas the 59 kDa component comigrates with the PTK fyn , the 85 to 90 kDa one is an unidentified Ser / Thr kinase . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Thus , whereas application of glutamate to hippocampal slices from control mice increased fyn protein tyrosine kinase ( PTK ) activity more than 2 . 5 fold , these changes were significantly impaired in LP BM 5 MuLV infected mice . ^^^ Moreover , mice with MAIDS exhibited an abnormal histological distribution of fyn PTK in the hippocampus . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We have found that killing is accompanied by tyrosine phosphorylation and activation of the CD 4 associated p 56 ( ICK ) kinase , and by activation of a second member of the scr family of PTK , p 59 ( fyn ) kinase , normally associated with T cell stimulation through the TCR . ^^^ These results are the first report where dual activation of the Lck and Fyn PTK does not result in normal downstream signaling through the ZAP PTK , We suggest by analogy to SCID resulting from ZAP 70 mutations , that the dissociation of upstream PTK activation from ZAP 70 signaling contributes to T cell depletion by HIV and to the development of AIDS . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| One of the earliest steps in the activation pathway is thought to involve the Src family PTKs , p 56 ( lck ) ( Lck ) and p 59 ( fyn ) ( Fyn ) ; however , the precise contribution of each PTK in TCR mediated signaling remains incompletely understood . ^^^ In this report , we demonstrate that specific inhibition of Lck expression in Th 2 cells , in the presence of normal levels of functional Fyn PTK , has profound consequences on multiple events following TCR stimulation , including an altered pattern of tyrosine phosphorylated substrates , defective phosphorylation of TCR zeta and ZAP 70 , defective Ca2+ mobilization , and a approximately 90 % reduction in proliferative responses to antigenic and mitogenic stimuli . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We identified 10 different PTK cDNAs among the 216 cDNAs sequenced , and demonstrate that transcripts of three of those ( ufo , fyn and fer ) are widely expressed among a large panel of immortalized thymic epithelial cell lines ( TEC ) and in primary cultures of TSC . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of gp 120 on TCR CD 3 induced phosphorylation and activation of the src type protein tyrosine kinases ( PTK ) , fyn and lck . gp 120 caused minimal changes in lck phosphorylation or lck enzymatic activity , but preincubation of Jurkat cells with gp 120 for 20 min strongly inhibited TCR CD 3 mediated phosphorylation and activation of lck and fyn , as well as phosphorylation of CD 3 zeta . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We used mice deficient in Lck , Fyn , or both Lck and Fyn to analyze the role that these src family PTK play in IEL development . ^^^ Interestingly , a small population of TcR gammadelta+ CD 8 alpha alpha+ cells are apparent in lck / fyn / animals , demonstrating that TcR alphabeta+ CD 8 alpha alpha+ and TcR gammadelta+ CD8alpha alpha+ IEL have distinct PTK requirements for their development or expansion . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In an effort to identify the targets that are specifically regulated by Fyn , we have studied the tyrosine phosphorylation of Pyk 2 , a recently discovered new member of the focal adhesion kinase family PTK . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| We have used peptide repertoires displayed by filamentous phage as a tool to study the substrate specificity of the protein tyrosine kinase ( PTK ) p 55 ( fyn ) ( Fyn ) . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this report , we investigated the role of c fyn protein , a src related protein tyrosine kinase ( PTK ) , during bryo 1 induced monocytic differentiation in a human leukemia cell line , THP 1 . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| When analysed for the total tyrosine phosphorylation of PTK , anergic HS 17 T cells induced by both molecules showed increased phosphorylation associated with only the fyn protein . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| By using co immunoprecipitation techniques and in vitro kinase assays , the uPAR associated proteins were identified as Janus ( Jak ) and Src non receptor protein tyrosine kinases ( PTK ) Jak 1 , Tyk 2 , and p 59 ( fyn ) , p53 / 56 ( lyn ) , p53 / 59 ( hck ) , and p 55 ( fgr ) . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| However , p 59 ( fyn ) immuno precipitates obtained from unstimulated peripheral blood SLE T cells showed enhanced PTK activity as compared to controls , whereas the PTK activity of p 56 ( lck ) and ZAP 70 molecules was comparable in both groups . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn , a member of the Src family protein tyrosine kinase ( PTK ) , is implicated in learning and memory that involves N methyl D aspartate ( NMDA ) receptor function . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| By overexpressing the two proteins , we show that the constitutive phosphorylation of Sam 68 in vivo directly correlates with cellular Fyn levels , but not with Lck expression , despite the capacity of the PTK to strongly phosphorylate the molecule in vitro . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the expression of the zeta chain molecule and the p 56 ( lck ) and p 59 ( fyn ) protein tyrosine kinase ( PTK ) levels in peripheral blood T lymphocytes ( T PBL ) from patients with advanced gastric carcinomas ; for this , flow cytometric analysis and immunoblotting , respectively , were used . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The proline , glutamic acid , serine and threonine enriched protein tyrosine phosphatase PEP , which is expressed primarily in hematopoietic cells , was recently discovered to be physically associated with the 50 kDa cytosolic protein tyrosine kinase ( PTK ) Csk , an important suppressor of Src family PTK , including Lck and Fyn in T cells . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Moreover , although transcripts encoding the src PTK fyn accumulate at 0 . 1 % of lck mRNA levels in thymocytes , diminished activity of the lck distal promoter in the B cell background brings lck and fyn transcript levels to near equivalence in this population . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the present studies , we extend our observations of PTK activation by examining a number of PAHs for their effects on total and specific ( Fyn and ZAP 70 ) PTK activity . ^^^ We found that only immunotoxic PAHs activated the Fyn and ZAP 70 PTKs at 10 min , but total PTK activity was still increased by nonimmunotoxic PAHs , BeP , or anthracene after 10 min of exposure . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| To test the hypothesis that p 59 ( fyn ) , a second src family protein tyrosine kinase ( PTK ) expressed in T lymphocytes , might be an essential upstream component of the CD 2 signaling pathway , we generated human ( h ) CD 2 transgenic ( tg ) fyn ( + / + ) and fyn ( / ) mice . ^^^ Collectively , these data identify p 59 ( fyn ) as a key PTK in CD 2 mediated activation of mature T lymphocytes . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| HIV SUgp 120 ( HIV surface glycoprotein ) , T cell receptor ( TCR ) CD4+ and co receptors promote aggregation of these lipid `` rafts ' ' which concentrate the Src family tyrosine kinases SFKs ( PTK , Lyn , Fyn , Lck ) , GPI ( glycosyl phosphatidylinositol ) anchored proteins , and phosphatidylinositol kinases PI ( 3 ) K and PI ( 4 ) K , inducing cell signalling . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The ubiquitous Src family protein tyrosine kinase ( PTK ) Fyn is not activated by these E 5 constructs , nor are focal adhesion kinase and endogenous receptor PTKs for insulin , epidermal growth factor , basic fibroblast growth factor and insulin like growth factor . ^^^ L26A E 5 does not transform SYF cells that are deficient for Src , Fyn and Yes , unless Src expression is reconstituted , and does not transform NIH3T3 cells in which Src PTK activity is maintained at a basal level by means of kinase defective K295R Src overexpression . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results suggested that the fyn product in Meth A cells augments the expression of a type 4 collagen binding protein through elevation of the PTK activity of the membrane fraction and thus facilitates the metastasis of Meth A . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the effects of protein tyrosine kinase ( PTK ) and protein tyrosine phosphatase ( PTP ) on the tyrosine phosphorylation of N methyl D aspartate receptor subunit 2A ( NR2A ) and the interactions among NR2A , postsynaptic density protein 95 ( PSD 95 ) , Fyn / Src after brain ischemia / reperfusion ( I / R ) . ^^^ The following results were observed : ( 1 ) the increase in tyrosine phosphorylation of NR2A induced by I / R was suppressed by genistein , an inhibitor of PTK , but was further enhanced by sodium orthovanadate , an inhibitor of PTP , which were administered to the SD rats 20 min before ischemia . ( 2 ) Importantly , genistein and sodium orthovanadate increased and decreased the interactions involving NR2A , PSD 95 , Fyn and Src , respectively . ^^^ These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A , PSD 95 , Fyn / Src . . ^^^ |
|
| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype , which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase ( PTK ) fyn knockout mice . ^^^ METHODS : We performed an association study of genetic variations of PTK fyn in 430 alcohol dependent patients and 365 unrelated control subjects from two independent samples . ^^^ CONCLUSIONS : Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn , with C being the risk allele . . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| The Dok 1 mutants having tyrosine to phenylalanine ( YF ) substitution ( s ) at Tyr 336 and / or Tyr 340 lost their inhibitory effect on Ras and Erk downstream of Src like PTK , Lyn or Fyn , whereas the rasGAP binding of each mutant remained intact . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn protein tyrosine kinase ( PTK ) , a member of the Src PTK family , is essential for myelin development in the central nervous system ( CNS ) . ^^^ Here we show that Fyn PTK is significantly up regulated in early OPC differentiation , concentrated in the compact myelin , and declines during myelin development . ^^^ Despite the high levels of Fyn PTK expression during early OPC differentiation , Fyn deficiency does not affect the expression of mRNAs that encode myelin structural proteins , including that for the myelin basic protein ( MBP ) , until postnatal day 13 ( P 13 ) . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Using purified proteins , we studied the ability of Syk , Fyn , and Abl to differentiate between tyrosines in a common PTK substrate , c Cbl . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Identification of a novel protein complex containing annexin 6 , Fyn , Pyk 2 , and the p 120 ( GAP ) C 2 domain . p 120 ( GAP ) ( RasGAP ) has been proposed to function as both an inhibitor and effector of Ras . ^^^ Here we provide evidence that p 55 is the Src family kinase Fyn and p 120 is the focal adhesion kinase family member Pyk 2 . ^^^ In addition , in vitro binding assays indicate that Fyn , but not Pyk 2 binds directly to annexin 6 . ^^^ Finally , co immunoprecipitation studies in Rat 1 fibroblasts confirm that Fyn , Pyk 2 , annexin 6 and RasGAP can form a protein complex in mammalian cells . . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| FIP 200 also inhibited the kinase activity of the Pyk 2 isolated from SYF cells ( deficient in Src , Yes , and Fyn expression ) and the Pyk 2 mutant lacking binding site for Src , suggesting that it regulated Pyk 2 kinase directly rather than affecting the associated Src family kinases . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| HFS enhanced association of the src family kinases fyn and c src with an approximately 120 kDa tyrosine phosphorylated component containing the focal adhesion kinase ( FAK ) and its homologue PYK 2 . ^^^ Association of fyn with FAK and of c src with PYK 2 was increased following the HFS . ^^^ These results suggest that fyn and c src are involved in distinct signaling pathways and provide evidence for activation of FAK and PYK 2 following synaptic stimulation inducing LTP in vitro . . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results indicate that CD 146 is coupled to a FYN dependent pathway that triggers Ca ( 2+ ) flux via phospholipase C gamma activation leading subsequently to the tyrosine phosphorylation of downstream targets such as Pyk 2 , p 130 ( Cas ) , FAK , and paxillin . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Using T cell hybridomas expressing either a wild type TCR or an alpha CPM mutant , we show that Fyn fails to be activated by the mutant receptor following SEB binding and fails to generate tyrosine phosphorylated Pyk 2 , a member of the focal adhesion kinase family . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Activation of Pyk 2 and Src / Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B ( NR2A / B ) and was blocked by a selective mGluR 1 antagonist , 7 ( hydroxyamino ) cyclopropa [ b ] chromen 1a carboxylate ethyl ester , but not an mGluR 5 antagonist , 2 methyl 6 ( phenylethynyl ) pyridine . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| This adhesion induces recruitment and activation of the focal adhesion kinase Pyk 2 , the cytoskeleton linker paxillin , and the Src kinases Lck and Fyn in the contact site . ^^^ |
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| Interacting proteins: Q14289 and P06241 |
Pubmed |
SVM Score :0.0 |
| Moreover , PYK 2 autophosphorylation and total tyrosine phosphorylation were profoundly altered in fyn / mice , revealing an important functional relationship between Fyn and PYK 2 in the hippocampus . ^^^ |
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