| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| The Src like kinases Lck and Fyn phosphorylate tyrosine residues in the cytoplasmic tail of CD 150 . ^^^ |
|
| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recently , another function for SAP was proposed : SAP can recruit the kinase Fyn to the SLAM ( CD 150 ) immune receptor . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP couples Fyn to SLAM immune receptors . ^^^ The crystal structure of a ternary SLAM SAP Fyn SH 3 complex reveals that SAP binds the FynT SH 3 domain through a surface surface interaction that does not involve canonical SH 3 or SH 2 binding interactions . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| We show here that SAP mutants found in XLP patients are defective in binding its physiological ligands signaling lymphocyte activating molecule ( SLAM ) , a co receptor in T cell activation , and Fyn , a Src family protein tyrosine kinase . ^^^ This is reflected by compromised abilities for the mutants to recruit Fyn to SLAM and to activate Fyn , by reduced phosphorylation of the receptor , and by deficiencies for the mutants in blocking binding of SHP 2 to SLAM . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| XLP is caused by mutations affecting SAP , an adaptor that recruits Fyn to SLAM family receptors . ^^^ SLAM engagement amplified PKC theta recruitment in wt but not SAP or Fyn deficient cells , arguing that a SAP / Fyn mediated pathway enhances PKC theta / NF kappaB 1 activation and suggesting a role for this pathway in T ( H ) 2 regulation . . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP also binds to the Src family tyrosine kinase Fyn and recruits it to SLAM , which leads to the generation of downstream phosphotyrosine signals . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| By interacting with SLAM family receptors , SAP enables tyrosine phosphorylation signaling of these receptors by its ability to recruit the Src related kinase , Fyn . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP is known to be a downstream molecule of SLAM family receptors and to mediate the activation signal for tyrosine kinase Fyn . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| SAP regulates T cell mediated help for humoral immunity by a mechanism distinct from cytokine regulation . 10 linked lymphoproliferative disease is caused by mutations affecting SH2D1A / SAP , an adaptor that recruits Fyn to signal lymphocyte activation molecule ( SLAM ) related receptors . ^^^ |
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| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13291 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
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