| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| T cell activation stimulates p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , Vav SLP 76 binding , and IL 2 transcription . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| In addition to binding the src kinase p 59 ( fyn ) , FYB binds specifically to the hematopoietic signaling protein SLP 76 , an interaction mediated by the SLP 76 SH 2 domain . ^^^ FYB is therefore a novel hematopoietic protein that acts as a component of the FYN and SLP 76 signaling cascades in T cells . . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| TcRzeta / CD3 ligation initiates a signaling cascade involving CD4 / CD8 p 56 ( lck ) , p 59 ( fyn ) , and ZAP 70 , as well as lymphoid downstream proteins VAV , SLP 76 , and FYB / SLAP . ^^^ |
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| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies demonstrate association of SLP 76 with SLAP 130 , Vav , Fyn , Lyn , and the FcR gamma chain in CRP stimulated platelets . ^^^ The physiological significance of this is uncertain , however , since tyrosine phosphorylation of SLP 76 in vivo is not altered in either Fyn or Lyn deficient platelets . ^^^ |
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| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn binding protein ( Fyb ) / SLP 76 associated protein ( SLAP ) , Ena / vasodilator stimulated phosphoprotein ( VASP ) proteins and the Arp2 / 3 complex link T cell receptor ( TCR ) signaling to the actin cytoskeleton . ^^^ We have identified the Fyn and SLP 76 associated protein Fyb / SLAP as a new ligand for Ena / vasodilator stimulated phosphoprotein ( VASP ) homology 1 ( EVH 1 ) domains . ^^^ |
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| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| The molecular adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) , also known as Fyn binding protein ( FYB ) or Slp 76 associated protein of 130 kilodaltons ( SLAP 130 ) , interacts with a number of signaling intermediates including Slp 76 , the Src family tyrosine kinase Fyn , vasodilator stimulated phosphoprotein ( VASP ) , and the actin nucleating protein WASP . ^^^ |
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| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Like other adapters , ADAP is a multifunctional protein and interacts with molecules such as Fyn , Slp 76 , Ena / VASP proteins , Vav 1 , WASP and the Arp2 / 3 complex . . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Immobilized ophioluxin was used to isolate the glycoprotein 6 Fcgamma complex from resting platelets , which also contained Fyn , Lyn , Syk , LAT , and SLP 76 . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| Among these LAT , SLP 76 and Gab 2 are critically important as adapters that facilitate events initiated by IgE receptor dependent activation of Src family protein tyrosine kinases , Lyn and Fyn . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| On mass spectrometric analysis of proteins binding to the SH 2 and SH 3 domains of Fyn , we identified six proteins that bind to Fyn including vimentin , pyruvate kinase , p 62 ras GAP associated phosphoprotein , SLP 76 , HS 1 , and FYB . ^^^ |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13094 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|