| To explore the therapeutic potential of blocking Tie 2 receptor interaction pathway , an adenoviral vector was used to deliver a recombinant single chain antibody fragment rabbit intrabody ( pAd 2S03 ) capable of inhibition of both mouse and human Tie 2 surface expression . pAd 2S03 was given to mice with well established primary tumors , either a human Kaposi ' s sarcoma ( SLK ) or a human colon carcinoma ( SW 1222 ) . ^^^ Our results show that the Tie 2 receptor pathway is essential for both SLK sarcoma and SW 1222 colon carcinoma xenograft growth . ^^^ |