| Interacting proteins: P06241 and P63244 |
Pubmed |
SVM Score :0.63492488 |
| Peptides that disrupt the interactions between RACK 1 , NR2B , and Fyn induce phosphorylation and potentiate NMDA receptor mediated currents . 0.63492488^^^ |
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| Interacting proteins: P06241 and P63244 |
Pubmed |
SVM Score :0.0 |
| We found that RACK 1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase , Fyn . ^^^ RACK 1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor mediated currents in CA 1 hippocampal slices ( Yaka , R . , Thornton , C . , Vagts , A . ^^^ We found that activation of the cAMP / protein kinase A pathway in hippocampal slices induced the release of RACK 1 from NR2B and Fyn . ^^^ Taken together our results suggest that activation of adenylate cyclase by PACAP ( 1 38 ) results in the release of RACK 1 from the NMDA receptor and Fyn . ^^^ |
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| Interacting proteins: P06241 and P63244 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that , in the hippocampus but not in the cerebral cortex , Fyn is targeted to the NR2B subunit of the NMDA receptor by the scaffolding protein RACK 1 . ^^^ During acute exposure to ethanol , RACK 1 is dissociated from the complex , thereby facilitating Fyn mediated phosphorylation of NR2B , which enhances channel activity , counteracting the inhibitory actions of ethanol . ^^^ |
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| Interacting proteins: P06241 and P63244 |
Pubmed |
SVM Score :0.0 |
| Peptides that mimic the binding sites for either Fyn or Src on receptor for activated C kinase 1 ( RACK 1 ) also enhanced NMDAR in CA 1 neurons , but their effects were blocked by Src ( 40 58 ) , implying that Src is the ultimate regulator of NMDARs . ^^^ RACK 1 serves as a hub for PKC , Fyn , and Src and facilitates the regulation of basal NMDAR activity in CA 1 hippocampal neurons . . ^^^ |
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