| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.54158896 |
| Fyn constitutively associated with and phosphorylated Cas , suggesting that Cas tyrosine phosphorylation may be catalyzed by Fyn . 0.54158896^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL , a member of the p130Cas docking protein family , in T cell receptor mediated signalling . ^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Notably , alpha 4 stimulated cell motility was inhibited by catalytically inactive receptor protein tyrosine phosphatase alpha overexpression and blocked by the p50Csk phosphorylation of c Src at Tyr 529 . alpha4beta1 stimulated cell motility of triple null Src ( / ) , c Yes ( / ) , and Fyn ( / ) fibroblasts was dependent on c Src reexpression that resulted in p130Cas tyrosine phosphorylation and Rac GTPase loading . ^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge . ^^^ The stretch activated substrate of Fyn and c Src , p130Cas , is also required for a rigidity response and it is phosphorylated at the leading edge in a Fyn dependent process . ^^^ A possible mechanism for the fibronectin rigidity response involves force dependent Fyn phosphorylation of p130Cas with rigidity dependent displacement . ^^^ With the greater displacement of Fyn from p130Cas on softer surfaces , there will be less phosphorylation . ^^^ |
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| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| On the contrary , the Cas associated kinase activity was remarkably decreased in Fyn / cells . ^^^ At the same time , association of Cas with Fyn kinase in vitro was most obviously detected in normal fibroblasts as well as Csk / cells . ^^^ Transient expression of 5 Crk induced elevation of the Cas associated kinase activity in all of these cell lines except the primary culture of Fyn / fibroblasts . ^^^ These results indicate that Fyn kinase plays an essential role in 5 Crk mediated phosphorylation of Cas . . ^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that immunoprecipitated Cas from beta 1 integrin stimulated ARH 77 cells was associated with tyrosine kinase and phosphatase activities and that integrin ligation led to the recruitment of at least p 59 ( Fyn ) tyrosine kinase and SHP 2 tyrosine phosphatase in Cas immune complexes . ^^^ Cotransfection studies in COS 7 cells further indicated that Fyn / Cas physical interaction and Fyn mediated Cas phosphorylation required amino acids 638 889 in the C terminal region of Cas . ^^^ In vitro binding studies using glutathione S transferase fusion proteins derived from the SH 2 or SH 3 domains of Fyn suggested that both Fyn domains can participate in Fyn / Cas interaction . ^^^ These data implicate Fyn and SHP 2 as potential modulators of Cas signaling complexes in B cells . . ^^^ |
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| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Using the substrate region of p 130 ( cas ) as the substrate , we found that Fyn and Src were activated on stimulation with KCl . ^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Hypertonicity provoked Fyn dependent tyrosine phosphorylation in beta catenin , alpha catenin , and p 120 ( Cas ) and caused the dissociation of beta catenin from the contacts . ^^^ |
|
| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results indicate that CD 146 is coupled to a FYN dependent pathway that triggers Ca ( 2+ ) flux via phospholipase C gamma activation leading subsequently to the tyrosine phosphorylation of downstream targets such as Pyk 2 , p 130 ( Cas ) , FAK , and paxillin . ^^^ |
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| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Possible involvement of Fyn kinase in ethanol stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex . ^^^ We further examined the possible involvement of Fyn kinase in ethanol stimulated Cas tyrosine phosphorylation . ^^^ Immunoprecipitation experiments also showed that Fyn was co immunoprecipitated with an anti Cas antibody in these regions from ethanol administered rats . ^^^ Furthermore , exogenous Fyn was shown to phosphorylate Cas from cerebellum and cerebral cortex in vitro . ^^^ These findings indicate that ethanol stimulates tyrosine phosphorylation of Cas in rat cerebellum and cerebral cortex , and that Fyn may be involved in the process . . ^^^ |
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| Interacting proteins: P56945 and P06241 |
Pubmed |
SVM Score :0.0 |
| Ethanol induced Cas tyrosine phosphorylation and Fyn kinase activation in rat brain . ^^^ Fyn kinase was shown to be activated by ethanol administration and to phosphorylate Cas on tyrosine residue in vitro . ^^^ Furthermore , Fyn kinase was co localized with Cas in rat cerebellum and cerebral cortex . ^^^ CONCLUSIONS : Cas was tyrosine phosphorylated in rat brain by ethanol administration , and Fyn kinase was most likely involved in the process . . ^^^ |
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