| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :1.1178487 |
| This study demonstrates that STEP ( 61 ) associates with Fyn , a member of the Src family kinases that is also enriched in PSDs . 1.1178487^^^ STEP ( 61 ) binds to Fyn through one of its proline rich domains and the kinase interacting motif domain , whereas Fyn binds to STEP ( 61 ) through its Src homology 2 domain and the unique N terminal domain . 0.74967513^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The CD 45 transmembrane protein tyrosine phosphatase ( PTPase , EC 3 . 1 . 3 . 48 ) plays an essential role in T cell activation by activating the Lck and / or Fyn protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| A defect in the biochemical pathway at the step of PBG conversion to uroporphyrinogen has been shown to be a result of a partial deficiency of the enzyme uroporphyrinogen 1 synthetase ( uro 1 syn ) . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine ( syn : sulphadimidine ) . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| This syn anti isomerization was the rate determining step in the duplex to coil transition . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| This step proceeds with syn stereochemistry , which fits the pattern of enzyme catalyzed elimination from substrates where the proton is lost from a position alpha to a ketone , an aldehyde , or a thiolester . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| An alternative pathway links ( zZzZz ) muconaldehyde with syn axial 2F2HP ( step a ' ) , and syn equatorial with ( eEzZz ) muconaldehyde ( step b ' ) . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| We have thus demonstrated that the activation of tyrosine kinases is an important proximate step in PAF mediated signal transduction in B cells , leading to tyrosine phosphorylation and activation of PLC gamma 1 , Fyn and Lyn kinases , and PtdIns 3 kinase . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results suggest that Fyn may be involved in the initial step of instinctive suckling behaviour in neonates . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| To understand more about the role of glutathione ( GSH ) in metabolism , we have cloned both cDNA and genomic sequences for mouse glutathione synthetase ( GSH syn ) , the enzyme that catalyzes the last step in the synthesis of glutathione . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Although each reaction catalyzed by these enzymes is initiated by this common step , their overall reactions ( including racemization , beta elimination of water , beta elimination of ammonia , and cycloisomerization ) as well as the stereochemical consequences ( syn vs anti ) of the beta elimination reactions are diverse . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Calculated distortions of duplex DNA by a cis , syn cyclobutane thymine dimer are unaffected by a 3 ' TpA step . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| For strong synaptic coupling , the velocity of both continuous and lurching pulses increases logarithmically with the synaptic coupling strength g ( syn ) for an exponential footprint shape , and it is bounded for a step footprint shape . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| G ( anti ) tetrads forms a platform on which stacks a T ( anti ) . [ A ( syn ) A ( anti ) ] triad containing a novel A ( syn ) A ( anti ) platform step and a reversed Hoogsteen A ( syn ) . ^^^ Unexpectedly , the topology of this sheared A ( anti ) G ( syn ) step has many similarities with the C ( anti ) G ( syn ) step in left handed Z DNA . ^^^ This intercalative topology is facilitated by a zipper like motif where the A ( anti ) residue of the triad is interdigitated within a stretched A ( anti ) G ( syn ) step . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| A step gradient of 40 80 % acetonitrile eluted SYN 2869 and the internal standard ( SYN 2506 ) . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The optimized synthetic route to the most potent inhibitor ( syn , syn 4 , K ( 1 ) = 2 . 0 nM ) proceeded in seven steps ( 87 % average yield per step ) from aminoindanol hydrocinnamide 40 and ( S ) fluoroiodoacetic acid , and allowed for the preparation of more than 1 g of this compound . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The endocyclic effect is subsequently capitalized upon to control the hydrogen transfer step so that the syn reduced product may be achieved . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Because ligation of the cell adhesion molecule F 3 on oligodendrocytes leads to activation of Fyn kinase localized in rafts , these findings suggest that recruitment of Tau and Tubulin to activated Fyn kinase in rafts is an important step in the initiation of myelination . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The unexpected and apparently unprecedented ( for C C bond forming reactions ) importance of the torsional rotation step , especially in the syn case , is due to the fact that all the barriers involved are low lying . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Epimerization at the phosphorus center ( syn right arrow over left arrow anti ) requires approximately 32 . 0 kcal / mol and occurs in a single step , reflecting a diradical like ring opening ring closure process that can occur in both a clockwise and counterclockwise fashion . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The dominant formation of this 3 : 1 coupling product , instead of the Heck trisubstituted olefin , shows that aromatic C H bond activation processes can compete with the usually fast syn beta hydrogen elimination step in the Heck arylation of an acyclic olefin . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The key step is represented by a thermal electrocyclic rearrangement of ( E , E ) 1 aryl 4 methylsulfonyl 2 nitro 3 phenylsulfonyl 1 , 3 butadienes ( 9 ) , which , thanks to proper geometric and electronic factors , occurs in unprecedentedly mild conditions and is followed by an irreversible , concerted syn beta elimination of methanesulfinic acid to aromatize the newly formed cyclohexadienic ring . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , it appears that the syn stereochemistry of the second step requires the phosphate leaving group to serve as the base in catalyzing its own elimination . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| The first step in T cell receptor for antigen ( TCR ) signaling is the activation of the receptor bound Src kinases , Lck and Fyn . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| When a bridging tether used to establish the cis , syn , cis stereochemistry in the intramolecular [ 2 + 2 ] photocyclization is present in the thermolysis step , however , the result of a formally `` symmetry forbidden ' ' fragmentation is observed yielding cis , cis cyclooctadiene containing 5 8 5 products . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Mechanistic studies of the olefination reaction between benzyl BTFP sulfone 7a and aromatic aldehydes performed by KOH induced Smiles rearrangement of stereodefined syn and anti beta hydroxyalkyl BTFP sulfones indicate that the stereocontrol of the reaction is determined in the elimination step . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| Determination of the absolute configurations of the syn and anti isomers of adduct 7b showed that the hydrogen atom abstraction step was significantly more stereoselective than the radical conjugate addition step . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| This proceeded with unprecedentedly high stereocontrol and offered an elegant method of generating the desired syn stereochemistry present in the final target in one step . . ^^^ |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54829 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|