| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , Grb 2 , Crk , Abl , p 85 phosphatidylinositol 3 kinase , and GTPase activating protein SH 2 domains showed lower or no binding to Fyn or Lck SH 3 domains . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| RPDE 6 exhibited selectivity in binding to the SH 3 domains of c Abl , Crk , Csk , Lck , Lyn , Fyn and 5 Src , with binding to the SH 3 regions of the Src related tyrosyl kinases Lyn and Fyn being the most effective . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| After insulin dependent tyrosine phosphorylation , c Cbl specifically associates with fusion proteins containing the Src homology 2 ( SH 2 ) domains of Crk and the Fyn tyrosine kinase , but not with fusion proteins containing the SH 2 domains of either the p 85 subunit of phosphatidylinositol 3 ' kinase or the tyrosine phosphatase SHPTP2 / Syp . ^^^ Furthermore insulin stimulates the association of c Cbl with endogenous c Crk and Fyn in intact 3T3 L 1 adipocytes . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , upon HUVEC stimulation with Sph 1 P , Crk , through its SH 2 domain , interacted with tyrosine phosphorylated Cas , and the Cas Crk complex translocated to the cell periphery ( membrane ruffles ) , through mediation of G ( 1 ) ( Fyn ) but not Rho . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor phosphorylated IRS5 / DOK4 associates with RasGAP , Crk , Src , and Fyn , but not phosphatidylinositol 3 kinase p 85 , Grb 2 , SHP 2 , Nck , or phospholipase Cgamma Src homology 2 domains , and activates MAPK in cells . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| One group of SH 2 domains ( Src , Fyn , Lck , Fgr , Abl , Crk , and Nck ) preferred sequences with the general motif pTyr hydrophilic hydrophilic Ile / Pro while another group ( SH 2 domains of p 85 , phospholipase C gamma , and SHPTP 2 ) selected the general motif pTyr hydrophobic 10 hydrophobic . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| Alpha 4 beta 1 integrin mediated tyrosine phosphorylation in human T cells : characterization of Crk and Fyn associated substrates ( pp 105 , pp 115 , and human enhancer of filamentation 1 ) and integrin dependent activation of p59fyn1 . ^^^ The association of these substrates with intracellular signaling intermediates , such as Crk and Fyn , may play a critical role in integrin mediated regulation of T cell function . . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| Each of these proteins contains an SH 3 domain , conferring association with focal adhesion kinase ; a domain rich in SH 2 binding sites , phosphorylated by or associating with a number of oncoproteins , including Abl , Crk , Fyn , and others ; and a highly conserved carboxy terminal domain . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ We found that rasGAP , Crk and Fyn bind in a SH 2 dependent manner to autophosphorylated HEK 2 . rasGAP , which contains two SH 2 and one SH 3 domain , was shown to associate with its N terminal SH 2 domain to HEK 2 . ^^^ Furthermore , we demonstrated that a single amino acid substitution ( Y614F ) clearly reduces the phosphotyrosine content of HEK 2 and abrogates its ability to bind rasGAP , Crk and Fyn indicating that this residue functions as major phosphorylation and multi docking site . ^^^ The conservation of this predicted binding site among various EPH related RTKs provides evidence that Fyn , Crk and rasGAP are key players in signal transduction of at least a subset of these receptors . . ^^^ |
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| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46108 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
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