| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| ZAP 70 , however , increased phagocytosis when coexpressed with the Src family kinase Fyn . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| T cell activation stimulates p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , Vav SLP 76 binding , and IL 2 transcription . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assays revealed that Fyn and Lck , but not ZAP 70 , were capable of phosphorylating CasL . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , PMA did not affect TCR induced tyrosine phosphorylation of CD3zeta or the PTKs Fyn and Zap 70 . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Genomic organization of the S locus : Identification and characterization of genes in SLG / SRK region of S ( 9 ) haplotype of Brassica campestris ( syn . rapa ) . ^^^ In the present study , we searched for expressed sequences in a 76 kb SLG / SRK region of the S ( 9 ) haplotype of Brassica campestris ( syn . rapa ) and identified 10 genes in addition to the four previously identified ( SLG ( 9 ) , SRK ( 9 ) , SAE 1 , and SLL 2 ) in this haplotype . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the regulatory effects of lck on ZAP 70 , syk , and PLC gamma 2 could not be replaced by overexpression of either fyn or src , demonstrating a selective role for lck in effectively coupling Fc gamma R stimulation to critical downstream signaling events . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Although protein tyrosine kinases such as Fyn and ZAP 70 were activated in Th 1 clones shortly after stimulation , these kinases in Th 2 clones were not activated ; but , their activity in resting conditions was shown to be decreased by the stimulation . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In addition , autophosphorylation of ZAP 70 when bound to zeta or eta resulted in the generation of multiple distinct ZAP 70 phosphorylated tyrosine residues which had the capacity to bind the SH 2 domains of fyn , lck , GAP , and abl . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Both the src family tyrosine protein kinases Lck , Fyn , Lyn and Blk and the syk family tyrosine protein kinases Syk and ZAP 70 play a role in lymphocyte activation . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recent biochemical and genetic evidence has implicated at least three cytoplasmic protein tyrosine kinases ( PTKs ) , Lck , Fyn , and ZAP 70 , that are involved in the initiation of TCR signal transduction . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic tyrosine residues in Ig beta were required for recruitment and activation of ZAP 70 , but these amino acids were not essential for the activation of Fyn and Lck . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Aggregation of the Syk chimera alone , or coaggregation of chimeras bearing Fyn and ZAP 70 kinases , suffices to initiate cytolytic effector function . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Here we report that Fyn becomes associated with the zeta associated tyrosine kinase , ZAP 70 , in a T cell hybridoma upon stimulation . ^^^ Mutational analysis of Fyn and ZAP 70 revealed that their kinase activities were relevant to the association . ^^^ Deletion of both the SH 2 and SH 3 domains of Fyn resulted in the decrease of the association with ZAP 70 . ^^^ Consistently , Fyn SH 2 and Fyn SH 3 fused to glutathione S transferase were able to bind to ZAP 70 . ^^^ These data suggest that multiple sites of Fyn and ZAP 70 are involved in the association . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| The T cell receptor specific kinases FYN , LCK , and ZAP 70 as well as the RAS pathway were found to be activated in T cells of Ctla 4 / mutant mice . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| These results are the first report where dual activation of the Lck and Fyn PTK does not result in normal downstream signaling through the ZAP PTK , We suggest by analogy to SCID resulting from ZAP 70 mutations , that the dissociation of upstream PTK activation from ZAP 70 signaling contributes to T cell depletion by HIV and to the development of AIDS . . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| However , Fyn deficiency has caused no overt defects in vivo on T cell development , nor has it caused any changes in the phosphorylation status of molecules such as ZAP 70 which have been proposed as p59fyn substrates . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the T cell antigen receptor CD 3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD 45 : evidence for two interconnected Lck / Fyn or zap 70 dependent signaling pathways . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Total amounts of protein tyrosine kinases ( PTKs ) Lck , Fyn , and ZAP 70 and the zeta chain of the TCR were found significantly decreased in T cells of symptomatic / AIDS patients as well as in T cells of individuals in acute and early asymptomatic stages of HIV infection . ^^^ Unexpectedly , the detection of Lck , Fyn , and ZAP 70 was reversed after the treatment of cell lysates with dithiothreitol . ^^^ This suggests that PTKs Lck , Fyn , and ZAP 70 were modified by a mechanism altering the status of sulfhydryl groups . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Beta 1 integrin mediated activation of focal adhesion kinase and its association with Fyn and Zap 70 in human NK cells . ^^^ In addition to p125FAK activity , FN induced kinase activity was also found to be mediated by Fyn , Lyn , and Zap 70 , as assessed by in vitro phosphorylation of the immunoprecipitated kinases in the presence of [ gamma 32P ] ATP . ^^^ Clustering of FN receptors on NK cells by agonists such as immobilized FN or alpha 4 or alpha 5 specific Abs also induced association of Fyn and Zap 70 with p125FAK . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that specific inhibition of Lck expression in Th 2 cells , in the presence of normal levels of functional Fyn PTK , has profound consequences on multiple events following TCR stimulation , including an altered pattern of tyrosine phosphorylated substrates , defective phosphorylation of TCR zeta and ZAP 70 , defective Ca2+ mobilization , and a approximately 90 % reduction in proliferative responses to antigenic and mitogenic stimuli . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Results demonstrate that in BW 5147 wild type TCR , tail less zeta TCR , CD3epsilon , and TCRzeta transduce signals leading to tyrosine phosphorylation of similar sets of cellular substrates , including the receptor subunits , Fyn , ZAP 70 , and phospholipase Cgamma 1 ( PLCgamma 1 ) . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In late endosomes , the internalized TCR / CD3 complex was found to be associated with an active protein kinase , distinct from p 56 ( lck ) and p 59 ( fyn ) , which were mainly present in early endosomes , and ZAP 70 , which was only present in the postnuclear supernatant . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Aberrant TCR mediated signaling in CD 45 null thymocytes involves dysfunctional regulation of Lck , Fyn , TCR zeta , and ZAP 70 . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was two fold : first , to investigate the levels of CD3zeta , p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , protein kinase C alpha ( PKC alpha ) and phospholipase C gamma ( PLC gamma ) in MM PBT cells ; second , to determine whether levels of expression were correlated with clinical or prognostic factors . ^^^ On average , PKC alpha was the only significantly decreased ( P < 0 . 001 ) signalling molecule , whereas levels of CD3zeta , p 56 ( lck ) , p 59 ( fyn ) , PLC gamma and ZAP 70 were not statistically different . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that NOD T cell hyporesponsiveness is associated with the ( a ) enhanced TCR beta associated Fyn kinase activity and the differential activation of the Fyn TCR zeta Cbl pathway , which may account for the impaired recruitment of ZAP 70 to membrane bound TCR zeta ; ( b ) relative inability of the murine son of sevenless ( mSOS ) Ras GDP releasing factor activity to translocate from the cytoplasm to the plasma membrane ; and ( c ) exclusion of mSOS and PLC gamma 1 from the TCR zeta associated Grb2 / pp36 38 / ZAP70 signaling complex . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Jak 3 was most sensitive to suppression by RCC S ; however , reduction in expression of p 56 ( lck ) , p 59 ( fyn ) , and ZAP 70 was observed in some experiments . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| The expression and phosphorylation of three major PTKs ( 1ck 56 , fyn 59 , zap 70 ) involved in signaling through the TCR were analyzed by enhanced chemiluminescence blots . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| We conclude that p 59 ( fyn ) and p 56 ( lck ) differently participate in regulating the phosphorylation state of Sam 68 in T cells and that ZAP 70 may contribute to Sam 68 tyrosine phosphorylation and to the specific recruitment of this molecule after CD 3 stimulation . . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Cross linking of the T cell antigen receptor ( TCR ) CD 3 complex induces rapid tyrosine phosphorylation and activation of Src ( Lck and Fyn ) and Syk ( Syk and Zap 70 ) family protein tyrosine kinases ( PTKs ) which , in turn , phosphorylate multiple intracellular substrates . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| T cell antigen receptor ( TCR ) engagement results in sequential activation of the Src protein tyrosine kinases ( PTKs ) Lck and Fyn and the Syk PTKs , ZAP 70 and Syk . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In addition , it was found that the in vitro kinase activities of the T cell receptor associated protein tyrosine kinase Lck ( p56Lck ) and ZAP 70 but not Fyn ( p59Fyn ) were lower in T cells from old rats than in T cells from young rats . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| TcRzeta / CD3 ligation initiates a signaling cascade involving CD4 / CD8 p 56 ( lck ) , p 59 ( fyn ) , and ZAP 70 , as well as lymphoid downstream proteins VAV , SLP 76 , and FYB / SLAP . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Upon removal of the PTP inhibitor , the tyrosine phosphorylated proteins , including Lck , Fyn , Syk , Zap 70 , and CD 35 zeta are rapidly dephosphorylated . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , the expression of actin , TCR zeta chain , ZAP 70 , and p 59 ( fyn ) remained similar in controls and infected mice . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| However , p 59 ( fyn ) immuno precipitates obtained from unstimulated peripheral blood SLE T cells showed enhanced PTK activity as compared to controls , whereas the PTK activity of p 56 ( lck ) and ZAP 70 molecules was comparable in both groups . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn and ZAP 70 are required for Vav phosphorylation in T cells stimulated by antigen presenting cells . ^^^ We investigated the role played by the protein tyrosine kinases Fyn , Lck , and ZAP 70 in these processes in a T cell hybridoma after physiological stimulation of the T cell receptor ( TCR ) and CD 28 . ^^^ A dominant negative mutant approach based on overexpression of catalytically inactive alleles of these kinases showed that CD 28 induced Vav phosphorylation preferentially requires Fyn , whereas ZAP 70 had no role . ^^^ These data suggest that Fyn plays a major role in controlling Vav phosphorylation upon T cell activation and that the mechanism implicating ZAP 70 in this process may be more complex than previously anticipated . . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Recombinant CD 45 AP exhibited specific binding to Lck and ZAP 70 protein tyrosine kinases , but not to Fyn or Csk , in lysates of both CD 45 positive and negative T cells . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| This is accompanied by a particular pattern of inhibition of early tyrosine kinases , including Zap 70 and p 59 ( fyn ) inhibition , but not overall inhibition of p 56 ( lck ) . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this report , we show that CTLA 4 can associate with the Src kinases Fyn and Lck and that transfection of Fyn or Lck , but not the unrelated kinase ZAP 70 , can induce tyrosine phosphorylation of CTLA 4 on residues Y 201 and Y 218 . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In particular , ES 62 acts by modulating activation of the tyrosine kinases Fyn , Lck and ZAP 70 leading to selective disruption of TCR coupling to the phospholipase D , protein kinase C , phosphoinositide 3 kinase and RasMAPkinase signalling cascades . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| T cell receptor ( TCR ) engagement results in the activation of Src family ( Lck and Fyn ) and ZAP 70 protein tyrosine kinases , leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c Cbl . ^^^ Here , we demonstrate that kinase dead but not wild type forms of Fyn , Lck , and ZAP 70 block 70Z Cbl mediated NFAT activation . ^^^ The requirement for Fyn , Lck , and ZAP 70 is not due to tyrosine phosphorylation of 70Z Cbl , as mutation of all tyrosines in , or deletion of , the C terminal region of 70Z Cbl ( amino acids 655 to 906 ) blocks 70Z Cbl tyrosine phosphorylation but enhances 70Z Cbl mediated NFAT activation . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Th 1 and Th 2 deviation of myelin autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck , Fyn , and ZAP 70 . ^^^ Th 0 to Th 1 deviation induced by peptide 86V > A correlated with up regulation of Fyn and ZAP 70 kinase activities . ^^^ Conversely , Th 0 to Th 2 deviation induced by peptide 88H > A was associated with complete failure to activate Fyn and ZAP 70 kinases . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| We report inhibition of early tyrosine kinases , including ZAP 70 , p 59 ( fyn ) , CD 4 associated p 56 ( lck ) and TCR components under this condition . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Fyn was able to induce tyrosine phosphorylation of the TCR and recruitment of the ZAP 70 kinase , but the pattern of TCR phosphorylation was altered and activation of ZAP 70 was defective . ^^^ These results indicate that Fyn mediates an alternative form of TCR signaling which is independent of ZAP 70 activation and generates a distinct cellular phenotype . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the present studies , we extend our observations of PTK activation by examining a number of PAHs for their effects on total and specific ( Fyn and ZAP 70 ) PTK activity . ^^^ We found that only immunotoxic PAHs activated the Fyn and ZAP 70 PTKs at 10 min , but total PTK activity was still increased by nonimmunotoxic PAHs , BeP , or anthracene after 10 min of exposure . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| The early CD 3 induced protein tyrosine phosphorylations are conserved in both CD 4 ( + ) and CD 8 ( + ) subsets , and the levels of the T cell protein tyrosine kinases p 56 ( Lck ) , p 59 ( Fyn ) and ZAP 70 are normal . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Notwithstanding the critical role of Lck and ZAP 70 in thymocyte development as compared to the related kinases Fyn and Syk , a partial functional redundancy between members of the same family of protein tyrosine kinases has emerged from studies on genetically manipulated mouse models . ^^^ Determination of the expression levels of Fyn , ZAP 70 and Syk in thymocytes form the Lck ( / ) thymoma revealed high levels of ZAP 70 overexpression and recovery of a specific subset of phosphoproteins as compared to Lck ( / ) thymocytes . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Activation of protein tyrosine kinases , Fyn and ZAP 70 , and turnover of inositol phosphates stimulated with anti CD 3 were severely impaired in old T cells , although levels of these proteins were comparable to those in young T cells . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| The electrophoretic mobilities of p 59 ( fyn ) or ZAP 70 were not changed in PMA treated cells but p 56 ( Ick ) migrated as a large band of M ( r ) 60 62 kDa . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the role played by the protein tyrosine kinases Fyn , Lck , and ZAP 70 in antagonist induced signaling pathway . ^^^ Antagonist stimulation increased tyrosine phosphorylation and kinase activity of Fyn severalfold , whereas little or no increase in Lck and ZAP 70 activity was observed . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , FcR nonbinding anti CD 3 mAbs induced tyrosine phosphorylation of the Fyn substrate Cbl , but not the ZAP 70 substrate linker for activation of T cells . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD 6 also associated with Lck , Fyn , and ZAP 70 , although at lower levels but additionally coprecipitated the Tec family kinase Itk , which is absent from CD 2 , CD 5 , and TCR complexes . ^^^ |
|
| Interacting proteins: P43403 and P06241 |
Pubmed |
SVM Score :0.0 |
| We analyzed jacalin induced intracellular signaling events in CD 4 ( + ) T cells and have shown that cell activation resulted in tyrosine phosphorylation of intracellular substrates p 56 ( lck ) , p 59 ( fyn ) , ZAP 70 , p 95 ( vav ) , phospholipase C gamma 1 , and ras activation , as assessed by conversion of ras guanosine 5 ' diphosphate to ras guanosine 5 ' triphosphate . ^^^ |
|