| Interacting proteins: P43121 and P06241 |
Pubmed |
SVM Score :0.0 |
| Consistent with these data , CD 146 associates with p 59 ( fyn ) , a Src family kinase known to phosphorylate p 125 ( FAK ) . ^^^ The identification of a signaling pathway initiated by CD 146 engagement and which includes p 59 ( fyn ) , p 125 ( FAK ) , and paxillin indicates that CD 146 participates in outside in signaling in endothelial cells . . ^^^ |
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| Interacting proteins: P43121 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD 146 engagement initiates an outside in signaling pathway involving the protein tyrosine kinases FYN and FAK as well as paxillin . ^^^ These results indicate that CD 146 is coupled to a FYN dependent pathway that triggers Ca ( 2+ ) flux via phospholipase C gamma activation leading subsequently to the tyrosine phosphorylation of downstream targets such as Pyk 2 , p 130 ( Cas ) , FAK , and paxillin . ^^^ |
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