| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| The Ig alpha chain cytoplasmic domain bound to the Src family kinases Lyn and Fyn , phosphatidylinositol 3 kinase ( PI 3 kinase ) , and an unidentified 38 kilodalton phosphoprotein ; the cytoplasmic tail of Ig beta bound PI 3 kinase and unidentified 40 and 42 kilodalton phosphoproteins . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| Of the tyrosine kinases transfected ( Lyn , Blk , Hck , Syk , Fyn ) , only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimeras in vivo . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| Both Ig alpha and Ig beta were able to trigger Fyn , Lck , and ZAP directly without involvement of TCR components . ^^^ Cytoplasmic tyrosine residues in Ig beta were required for recruitment and activation of ZAP 70 , but these amino acids were not essential for the activation of Fyn and Lck . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| Alternatively , Lyn , may be a downstream effector of phosphorylated Ig alpha and Ig beta as suggested by the reported ability of biphosphorylated Ig alpha to activate Fyn PTK in vitro . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| In addition to binding to the phosphorylated cytoplasmic domains of Ig alpha and Ig beta , blk and fyn ( T ) , two members of the src family kinases , have been shown to bind overlapping but distinct sets of phosphoproteins [ Malek & Desiderio ( 1993 ) J . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptors ( BCR ) are composed of an antigen binding subunit , the membrane Ig , and Ig alpha / Ig beta heterodimers , that contain a transducing motif named ITAM for `` immuno receptor tyrosine based activation motif . ' ' Ig alpha and Ig beta ITAMs only differ by four amino acids located before the second conserved tyrosine ( DCSM in Ig alpha and QTAT in Ig beta ) , which determine the in vitro association of Ig alpha with the src kinase fyn . ^^^ These data show that alterations that modify the ability of Ig alpha and Ig beta to interact in vitro with the src kinase fyn ( switch between QTAT and DCSM ) also determine signal transduction capabilities of these molecules expressed in B cells . . ^^^ |
|
| Interacting proteins: P40259 and P06241 |
Pubmed |
SVM Score :0.0 |
| Furthermore , at least 25 % of phosphorylated p40 / 42 co immunoprecipitated with Ig alphabeta , but none precipitated with MHC 2 , CD 40 , Fc ( gamma ) RII , Fyn , HS 1 , or Syk , suggesting that this protein complex specifically associates with the Ig alphabeta heterodimer . p40 / 42 did not react with Abs to Ig alpha , Ig beta , mitogen activated protein kinase , or Lnk . ^^^ |
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