| Interacting proteins: P35612 and P06241 |
Pubmed |
SVM Score :0.52710794 |
| We have previously reported that Fyn binds to a cytoskeletal protein , beta adducin , in a phosphorylation dependent manner . 0.52710794^^^ |
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| Interacting proteins: P35612 and P06241 |
Pubmed |
SVM Score :0.0 |
| Interaction of the SH 2 domain of Fyn with a cytoskeletal protein , beta adducin . ^^^ To understand the function of Fyn tyrosine kinase , we attempted to identify Fyn Src homology 2 ( SH 2 ) domain binding proteins from a Nonidet P 40 insoluble fraction of the mouse brain . beta Adducin , an actin filament associated cytoskeletal protein , was isolated by two dimensional gel electrophoresis and identified by tandem mass spectrometry . beta Adducin was tyrosine phosphorylated by coexpression with wild type but not with a kinase negative form of Fyn in COS 7 cells . ^^^ Cell staining analysis showed that coexpression of beta adducin with Fyn induced translocation of beta adducin from the cytoplasm to the periphery of the cells where it was colocalized with actin filaments and Fyn . ^^^ These findings suggest that tyrosine phosphorylated beta adducin associates with the SH 2 domain of Fyn and colocalizes under plasma membranes . . ^^^ |
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| Interacting proteins: P35612 and P06241 |
Pubmed |
SVM Score :0.0 |
| We conclude that Fyn is a downstream target of the PTN / RPTPbeta / zeta signaling pathway and suggest that PTN coordinately regulates tyrosine phosphorylation of beta catenin , beta adducin , and Fyn through the PTN / RPTPbeta / zeta signaling pathway and that together Fyn , beta adducin , and beta catenin may be effectors of the previously described PTN stimulated disruption of cytoskeletal stability , increased cell plasticity , and loss of cell cell adhesion that are characteristic of PTN stimulated cells and a feature of many human malignant cells in which mutations have established constitutive expression of the Ptn gene . . ^^^ |
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