| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| We conclude that Fyn is a downstream target of the PTN / RPTPbeta / zeta signaling pathway and suggest that PTN coordinately regulates tyrosine phosphorylation of beta catenin , beta adducin , and Fyn through the PTN / RPTPbeta / zeta signaling pathway and that together Fyn , beta adducin , and beta catenin may be effectors of the previously described PTN stimulated disruption of cytoskeletal stability , increased cell plasticity , and loss of cell cell adhesion that are characteristic of PTN stimulated cells and a feature of many human malignant cells in which mutations have established constitutive expression of the Ptn gene . . ^^^ |
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| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| Whereas skin of fyn / mice appears normal , skin of mice with a disruption in both the fyn and src genes shows intrinsically reduced tyrosine phosphorylation of beta catenin , strongly decreased p 120 Cas levels , and important structural changes consistent with impaired keratinocyte cell adhesion . ^^^ |
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| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| Hypertonicity provoked Fyn dependent tyrosine phosphorylation in beta catenin , alpha catenin , and p 120 ( Cas ) and caused the dissociation of beta catenin from the contacts . ^^^ |
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| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| Catenin associated Fer and Fyn tyrosine kinases regulate beta catenin Tyr 142 phosphorylation and beta catenin alpha catenin Interaction . beta Catenin has a key role in the formation of adherens junction through its interactions with E cadherin and alpha catenin . ^^^ Stable transfectants of the K ras oncogene in intestinal epithelial IEC 18 cells were generated which show little alpha catenin beta catenin association with respect to control clones ; this effect is accompanied by increased Tyr 142 phosphorylation and activation of Fer and Fyn kinases . ^^^ These results indicate that p 120 catenin acts as a docking protein facilitating the activation of Fer / Fyn tyrosine kinases by Yes and demonstrate the role of these p 120 catenin associated kinases in the regulation of beta catenin alpha catenin interaction . . ^^^ |
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| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35222 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
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