| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Shc associates with the SH 3 domain of Fyn whose tyrosine kinase activity is activated by Ang 2 with a similar time course as that of tyrosine phosphorylation of Shc . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| CD 45 dependent events such as tyrosine phosphorylation of Shc , activation of nuclear factor kappa B ( NF kappa B ) , activator protein 1 ( AP 1 ) , transcription factors , and stimulation of interleukin 2 ( IL 2 ) promoter and of CD 69 and CD 25 surface expression paralleled activation of the tyrosine kinases lck and fyn . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| In contrast , Shc , phosphatidylinositol 3 kinase ( Pl3K ) , Grb 2 , and Ras GTPase activating protein ( GAP ) bound with different affinities to the bis or monophosphorylated peptides , while the Src family protein tyrosine kinase ( PTK ) Fyn did not bind specifically to any of the tested peptides . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Binding of FYN and SHC to the diphosphorylated Tyr568 / 570 site was observed , while binding of Csk to this site was not observed . ^^^ The SH 2 ( CHK ) binding to the two sites is direct and not through phosphorylated intermediates such as FYN or SHC . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Upon integrin ligation , Fyn is activated and binds , via its SH 3 domain , to Shc . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Shc tyrosine phosphorylation and Ras activation by H ( 2 ) O ( 2 ) were also significantly reduced in Fyn / cells , but not altered in Src / cells . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| The complex formations of Fyn Shc , Shc Grb 2 , and Grb 2 mSOS were detected in the activated Fyn transformed cells , whereas the SH 2 deletion mutant of Fyn failed to form a complex with mSOS . ^^^ Moreover , tyrosine phosphorylation of Shc was induced by the overexpression of the activated Fyn . ^^^ These findings support the idea that Fyn activates the activity of mSOS bound to Grb 2 through tyrosine phosphorylation of Shc . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases , Grb 2 and Shc adaptors , and the p 85 subunit of phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Caveolin , which was translocated to noncaveolar sites in response to stretch , is associated with beta 1 integrins as well as with Fyn and Shc , components required for ERK activation . ^^^ Taken together , caveolin in caveolae may keep ERK inactive , but when caveolin is translocated to noncaveolar sites in response to stretch stress , caveolin mediates stretch induced ERK activation through an association with beta 1 integrins / Fyn / Shc . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| The LHR mediated phosphorylation of the EGFR and Shc , the activation of Ras , and the phosphorylation of ERK1 / 2 are inhibited by expression of a dominant negative mutant of Fyn , a member of the Src family kinases ( SFKs ) expressed in MA 10 cells and by PP 2 , a pharmacological inhibitor of the SFKs . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| This activation was blocked by inhibitors of both FGFR and Fyn , indicating that NCAM activates FGFR signaling in a manner distinct from FGF 2 stimulation , and regulates ShcA phosphorylation by the concerted efforts of the NCAM / FGFR as well as the NCAM / Fyn signaling pathway . . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Using the phosphotyrosine binding domains of the Shc adaptor and the Fyn kinase , which both participate in CD 4 signaling , as baits , we show that CD 4 induces tyrosine phosphorylation of a subset of the proteins phosphorylated in response to TCR / CD3 engagement . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| Using a GST fusion protein carrying the cytoplasmic tail of beta dystroglycan , we identified five SH 2 domain containing proteins that interact with beta dystroglycan in a phosphorylation dependent manner , including c Src , Fyn , Csk , NCK , and SHC . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| In R IGF IRWT cells , IGF 1 causes Fyn enrichment in the caveolae with a time course consistent with Shc phosphorylation and Grb 2 recruitment in these regions . ^^^ |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29353 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|